Bilateral ovarian teratoma in a free-living Iberian red deer (<i>Cervus elaphus hispanicus</i>)

Höfle, Úrsula; Vicente, Joaquı́n; Gortázar, Christian

doi:10.1080/00480169.2004.36390

Cited by 8 publications

(6 citation statements)

References 5 publications

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“…Ovarian epithelial neoplasms are uncommon tumors in domestic and nondomestic animals, [1] but have been reported in the bovine, pig, [2] small ruminants, [3] canine, [4] cat, [5] mare, [6] deer, [7,8] and jaguar [9]. Except in the dog, [10] epithelial ovarian tumors occur less frequently than those of mesenchymal origin.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Metastatic ovarian papillary cystadenocarcinoma to the small intestine serous surface: report of a case of high-grade histopathologic malignancy

et al. 2014

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Ovarian cystadenocarcinoma is characterized by marked heterogeneity and may be composed of an admixture of histologic growth patterns, including acinar, papillary and solid. In the present study, a case of isolated small intestine metastasis of ovarian papillary cystadenocarcinoma was reported. A 7-year-old female mixed-breed dog presented with a mass in the left upper quadrant with progressive enlargement of the abdomen, periodic bloody discharge from the vulva and incontinence. The tumor was histologically characterized by the presence of cysts and proliferation of papillae, both lined by single- or multi-layered pleomorphic epithelial cells. Furthermore, the mass was composed by intense cellular and nuclear pleomorphism and numerous mitotic figures. These findings indicate a tumor of high-grade malignancy with infiterative tumor cells resembling the papillary ovarian tumor in the serosal surface of the small intestine along with an intact serosa. Immunohistochemically, tumor was positive for CK7 and negative immunoreactivity for CK20. The histopathologic features coupled with the CK7 immunoreactivity led to a diagnosis of high grade ovarian papillary cystadenocarcinoma. To the best of our knowledge, this is the first case of small intestine serousal surface metastasis from ovarian papillary cystadenocarcinoma.

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Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Metastatic ovarian papillary cystadenocarcinoma to the small intestine serous surface: report of a case of high-grade histopathologic malignancy

et al. 2014

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“…They occur sporadically in a variety of species ranging from amphibia to the mammals (Flux 1965;Bukovjan and Karpenko 1990;Munson and Montali 1991;Karpenko and Bukovjan 1996;Hofle et al 2004;Fitzgerald et al 2007). The finding of an ovarian carcinoma in a badger is unique and to the knowledge of the authors has yet to be reported.…”

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confidence: 75%

Bilateral low grade serous adenocarcinoma of the ovaries in a badger (Meles meles L.) and its association with a borderline serous ovarian tumour: a case report

Kutlvašr¹,

Bukovjan²,

Kodet³

2014

Vet. Med. - Czech

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ABSTRACT:Here, we describe a case of a wild female badger (a sow) with disseminated serous adenocarcinoma of the ovary which corresponds to a group of low grade serous carcinomas of the ovary in humans. Beside grossly apparent dissemination of the disease we observed a scale of histological features classifiable as a precursor lesion -borderline serous tumour of the ovary with implant metastases at the peritoneum, and features of the borderline tumour transformation in the carcinoma. The latter features included invasion of some of the metastatic peritoneal implants into the adipose tissue of the mesentery, retroperitoneum, and in the muscle of diaphragm with lymphangioinvasion and with blood-borne metastatic disease in the lungs. The primary tumour and its metastases had a uniform cytological appearance without atypia of the tumour cells. Mitotic activity was exceptional. The proliferation activity as demonstrated by immunohistochemical investigation of Ki-67 protein expression (revealing all active phases of the cell cycle -G1, S, G2, M) showed a low proliferation activity of the tumour cells, comparable with findings in low grade carcinomas or borderline tumours of the ovaries in women. WT1 protein was expressed in the whole tumour cell population. All these features were diagnostic of serous carcinoma of the ovary with low grade malignant potential. Tumours of the ovaries in wildlife have been described previously but they are infrequent and are rarely classified histopathologically. This case report offers a parallel with serous carcinomas in human pathology including features of transformation from a precursor lesion of a borderline serous tumour into a serous low grade carcinoma.

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“…Mature ovarian teratomas have also been described in accessory ovaries in women as well as in ovaries of animals. 15,16 Ovarian dermoids continue to surprise us. Some of them are associated with NMDAR encephalitis, a paraneoplastic syndrome in which patients manifest with neuropsychiatric manifestations, which usually resolve after surgical excision of the tumor.…”

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confidence: 99%

Fetal Glomeruli in a Mature Ovarian Teratoma: A Developmental Anomaly Within a Developmental Anomaly?

Pai

2019

Int J Surg Pathol

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A mature ovarian teratoma in a 22-year-old woman showed various commonly noted components, including respiratory epithelium, adipose tissue, nerve bundles, skeletal muscles, hemosiderin-laden macrophages, lymphocytes, and bone. In addition, there were other structures that were decidedly uncommon-fetal glomeruli (Figures 1 and 2). Mature ovarian teratomas are fascinating neoplasms that contain a plethora of tissues of ectodermal, mesodermal, and endodermal origin and include, most often, skin with adnexae, hair, neural tissues, cartilage, bone, teeth, respiratory and gastrointestinal tract tissue, adipose tissue, and smooth muscle. Thyroid tissue, cerebellum, retina, and, remarkably, even prostatic tissue has been noted. 1-8 Renal elements are rare but have been reported. 2-5 Because of the excessive ectodermal component of skin and hair, many mature teratomas are also referred to as dermoid cysts. Teratomas, even though not congenital, are the result of disordered development. Willis suggests that teratomas are tumors arising from foci of plastic pluripotential embryonic tissue, which escaped the influence of the primary organizer during early development. 9 Because the presence of fetal glomeruli in an adult could also constitute a developmental anomaly, one may wonder if this case represents a developmental anomaly within a developmental anomaly! This is not so. Mature teratomas, by definition, contain only mature tissue. 1-5 It must be noted, however, that microscopic amounts of immature glial tissue are still compatible with the diagnosis of a mature teratoma. A standard definition of mature ovarian teratoma states that "all of the components present in mature cystic teratomas should appear histologically mature." 1 Another textbook mentions that "classic mature cystic teratomas usually contain mature tissues from 2 or 3 embryonic layers," while a popular and reliable website on diagnostic pathology characterizes teratomas as "mature if only contains adult tissues." 4,6 However, another reference book states that these teratomas contain "normal fetal to adult tissues variably mixed but organized." 5 Furthermore, Sternberg's textbook mentions that "dermoid cysts are composed of adult-type tissue and sometimes a small amount of fetal-type tissue." 2 A final clarification is seen in Robboy's book, which states, "Various mature tissues are usually present" but clarifies that these tissues "correspond to that of developing fetus of over 8 weeks 877505I JSXXX10.

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Bilateral ovarian teratoma in a free-living Iberian red deer (Cervus elaphus hispanicus)

Abstract: This case describes the first known description of an ovarian teratoma in a free-living red deer. The tumour had unique features, such as bilateral presence and concurrency with a normal pregnancy.

Cited by 8 publications

References 5 publications

RETRACTED ARTICLE: Metastatic ovarian papillary cystadenocarcinoma to the small intestine serous surface: report of a case of high-grade histopathologic malignancy

RETRACTED ARTICLE: Metastatic ovarian papillary cystadenocarcinoma to the small intestine serous surface: report of a case of high-grade histopathologic malignancy

Bilateral low grade serous adenocarcinoma of the ovaries in a badger (Meles meles L.) and its association with a borderline serous ovarian tumour: a case report

Fetal Glomeruli in a Mature Ovarian Teratoma: A Developmental Anomaly Within a Developmental Anomaly?

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