Bilateral parotid enlargement due to malnutrition under the influence of the media in an adolescent in Lithuania

Mieliauskaitė, Diana; Venalis, Algirdas; Gražienë, Vida; Kirdaitė, Gailutė

doi:10.1016/j.appet.2006.11.006

Cited by 2 publications

(2 citation statements)

References 7 publications

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“…Malnutrition is one condition that mimics parotitis and thus SS. When malnutrition and parotitis are present, anorexia/ bulimia [16] or HIV disease [17] should be suspected.…”

Section: Parotitis and Sicca Syndromementioning

confidence: 99%

Sjögren’s syndrome in childhood

Singer

Tomanova-Soltys²,

Lowe³

2008

Curr Rheumatol Rep

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This review presents our 10-year experience with children diagnosed with Sjögren's syndrome (SS). Patients between the ages of 9 and 17 years had abnormalities in laboratory values consistent with but not entirely diagnostic of those required to diagnose SS in adults. The spectrum of clinical manifestations suggests that the SS clinical phenotype in children is more variable than that in adults. Here, we review manifestations of SS in children. Our patients were treated with hydroxychloroquine, despite the lack of prospective data about effects on SS progression and/or autoantibody spreading. Patients have been followed for between 3 and 6 years without substantial progression of their disease or change in autoantibody status. Longer term follow-up (10-20 years) is needed to define the natural history of SS in childhood and its treatment outcomes. Prospective validation of SS criteria in childhood could facilitate assessment of the utility of hydroxychloroquine and other therapies.

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“…Malnutrition is one condition that mimics parotitis and thus SS. When malnutrition and parotitis are present, anorexia/ bulimia [16] or HIV disease [17] should be suspected.…”

Section: Parotitis and Sicca Syndromementioning

confidence: 99%

Sjögren’s syndrome in childhood

Singer

Tomanova-Soltys²,

Lowe³

2008

Curr Rheumatol Rep

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“…Therefore, concerns are raised that more extended periods of continuous exposure to high doses of ubiquinone may result in an adaptive malfunction of the salivary glands that warrants precautions. For this reason, the changes in the diameters of salivary glandular serous acini can be considered a sensitive early indicator of salivary gland functional adaptation to an external effector element, including malnutrition or specific disease conditions such as Chagas disease [16,17].…”

Section: Discussionmentioning

confidence: 99%

Histopathological comparison of the salivary glands’ acini and striated ducts after experimental prolonged daily administration of oral ubiquinone doses in rats

Abdullah

Sedeeq

Azzubaidi

2021

Current Issues in Pharmacy and Medical Sciences

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Also called coenzyme Q10 (CoQ10), Ubiquinone is a vitamin-like endogenously produced factor essential for Adenosine triphosphate (ATP) mitochondrial production. Several research studies have reported that the exogenous supplementation of CoQ10 can lead to excessive salivation, especially in patients complaining of dry mouth. The objective of this study was to investigate the effect of long-term daily use of CoQ10 on the salivary glands in experimental animals by comparing the diameters of the glandular acini and striated ducts of a CoQ10-treated group and a control group. Twenty-five white albino rats were randomly divided into two groups; the control group consisted of 10 rats, while the CoQ10-treated group comprised 15 rats. The latter received daily oral treatment of 300 mg/kg CoQ10 for six weeks. Samples of the parotid, submandibular and sublingual glands were then dissected and examined histologically for comparative measurement of the diameters of the glands’ acini and striated ducts. The CoQ10 treated group had mean diameters of the serous acini for the parotid (79.8±11.2 μm) and submandibular (81.07±13.5 μm) glands that were significantly higher (P<0.05) than their diameters in the control group (67.5±8.4 μm and 73.3±13.8 μm), respectively. However, the difference was not statistically significant when comparing the diameters of striated ducts of the CoQ10-treated group and the control group. Continuous and prolonged exposure to exogenous ubiquinone may cause hypertrophic dilation of the acini within the salivary glands, namely the parotid and submandibular glands, which might be the underlying mechanism for excessive salivation. This can be considered a reversible adaptive response.

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Bilateral parotid enlargement due to malnutrition under the influence of the media in an adolescent in Lithuania

Cited by 2 publications

References 7 publications

Sjögren’s syndrome in childhood

Sjögren’s syndrome in childhood

Histopathological comparison of the salivary glands’ acini and striated ducts after experimental prolonged daily administration of oral ubiquinone doses in rats

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