Bilateral pedicle stress fracture with adjacent old osteoporotic compression fractures that induced spondylolisthesis

Phenotypic characterization of Slc26a2 mutant mice reveals a multifactorial etiology of spondylolysis

“…6,19 However, multiple case reports have described an unusual condition of osteoporotic spondylolisthesis. 54 Moreover, two studies based on different populations demonstrated a potential correlation between increased bone mineral density and lumber spondylolisthesis. 52 Hajjioui reported a spondylolisthesis on L4-L5 related to steroidinduced osteoporosis in a 54-year-old woman without any history of trauma or spine surgery.…”

“…53 Similarly, a rare case of spondylolisthesis caused by bilateral lumbar pedicle fracture with adjacent old osteoporotic compression fractures was reported by Kang et al in a 76-year-old woman with osteoporosis. 54 Moreover, two studies based on different populations demonstrated a potential correlation between increased bone mineral density and lumber spondylolisthesis. 55,56 Thus, whether osteoporosis involves in pathogenesis of spondylolysis and its progression to spondylolisthesis needs further investigation, especially in patients who have family history of pars lysis.…”

Spontaneous Atraumatic Bilateral Pedicle Insufficiency Fractures

“…12,13 To date, there is no confirmed method of treatment because of its rarity. 2 This report represents one of the first cases of "de novo" atraumatic pedicle insufficiency bilateral fractures without any pre-existing biomechanical risk factors. We believe this type of fracture is easily overlooked on plain radiographs if undisplaced, 21 thus justifying advanced modalities if suspected.…”

“…Isolated bilateral pedicle fractures in the spine are rare, and an extremely uncommon etiology for spondylolisthesis. [1][2][3] We report a case of bilateral pedicle stress fractures accompanying spondylolisthesis in a patient taking Risedronate for 10 years. This is the first reported case of spondylolisthesis accompanying spontaneous bilateral pedicle stress fractures involving one vertebra in a patient on bisphosphonate therapy for osteoporosis.…”

“…6 They can present as a unilateral pedicle fracture with contralateral pars lysis, 4,7 it can happen in one or more levels in the lumbar spine, 8,9 or they may be associated with spondylolisthesis. 2,3 In younger adults the diagnosis is extremely rare and is nearly always associated with sports in which hyperextension is common (e.g., ballet), whereas in older adults it is usually due to non-diagnosis of a defect from adolescence presenting later with associated LBP. 10,11 Pedicle stress fractures may present as an acute traumatic fracture or have signs of established pseudoarthrosis.…”