Bilateral persistent hyperplastic primary vitreous

Sanghvi, D A; Sanghvi, C; Purandare, N.

doi:10.1111/j.1440-1673.2005.01402.x

Cited by 30 publications

(18 citation statements)

References 2 publications

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“…Doppler may show arterial flow within this band, representing a persistent hyaloid artery. 6 CT scan, although better than USG in demonstrating absence of calcification, should not be routinely used as it carries radiation risk.…”

Section: Discussionmentioning

confidence: 97%

Bilateral Persistent Hyperplastic Primary Vitreous: A Close Mimic of Retinoblastoma

Rizvi

Siddiqui

Khan

et al. 2013

Seminars in Ophthalmology

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Bilateral persistent hyperplastic primary vitreous (PHPV) is a rare disorder of eye. It is one of the most important differential diagnoses of retinoblastoma, hence early and accurate diagnosis is important. We here report a case of an 11-month-old child which was referred to ocular OPD with complaints of bilateral leukocoria. Examination revealed greyish-white masses posterior to both lenses, raising the clinical suspicion of retinoblastoma. Ultrasonography demonstrated echogenic masses extending from the posterior surface of the lens to the optic disc with reduced axial lengths. These masses demonstrated flow on color Doppler evaluation. CT scan revealed hyperdense masses behind the lens without any evidence of intralesional calcification. Clinical features and imaging findings point towards the diagnosis of bilateral PHPV. PHPV is a developmental disorder of the globe in which the hyaloid vasculature fails to regress normally. While unilateral PHPV is common, bilateral PHPV is a rare entity. It is one of the most important conditions mimicking retinoblastoma; hence early and accurate diagnosis is required. Ophthalmological examination is still the best way to confirm the diagnosis. However, if the diagnosis remain unclear, further evaluation using ultrasonography, Color Doppler, and CT scan is useful.

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Section: Discussionmentioning

confidence: 97%

Bilateral Persistent Hyperplastic Primary Vitreous: A Close Mimic of Retinoblastoma

Rizvi

Siddiqui

Khan

et al. 2013

Seminars in Ophthalmology

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“…On 2D ultrasonography, an echogenic inhomogeneous band is seen which extends from the posterior surface of the capsule of the lens to the optic disc. On colour Doppler, arterial flow may be seen in this band which represents persistent hyaloid artery 8. CT findings of PFV are microphthalmia, a small or irregular lens, infiltration of the vitreous cavity giving the appearance of a hyperdense vitreous body, and tubular intravitreal density (Cloquet's canal).…”

Section: Discussionmentioning

confidence: 99%

Bilateral persistent fetal vasculature: mimicker of retinoblastoma

Kumar¹,

Yadav

2017

BMJ Case Reports

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We describe a case of bilateral persistent fetal vasculature (PFV) in a 3-month-old boy who presented with bilateral white pupillary reflex and a possible diagnosis of retinoblastoma. On ultrasonography, there was an echogenic band in the posterior segment of both eyes which connected the posterior surface of the lens capsule to the optic disc. Colour Doppler revealed the presence of vascularity in the band along its entire length. No calcification or mass lesion was seen. These findings are diagnostic of PFV. Most cases of PFV are unilateral and sporadic in nature and closely mimic retinoblastoma. Although rare, PFV should be considered in the differential diagnosis when examining a case of bilateral leukocoria. Paediatricians should be aware of this rare but serious entity.

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“…1,2,8,[16][17][18][19] In a study by Pollard 14 of 83 patients with PFV, only 2 (2.4%) had bilateral involvement. In his description of posterior PFV, Pruett 20 reported 5 of 30 patients with bilateral involvement.…”

Section: Discussionmentioning

confidence: 99%