Bilateral persistent hyperplastic primary vitreous: A rare entity

Galhotra, Ritu; Gupta, Kamini; Kaur, Samarjeet; Singh, Paramdeep

doi:10.4103/0974-620x.94780

Cited by 8 publications

(3 citation statements)

References 5 publications

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“… 3 Bilateral presentations are rare and are associated with systemic and syndromic associations, such as trisomy, Norrie’s disease, and Warburg’s syndrome. 4 Systemic abnormalities, including cleft lip, cleft palate, polydactyly, and microcephaly, could potentially be associated with chromosomal abnormalities. Although a relationship between genetic abnormalities and PHPV has not been reported, several cases of PHPV have been observed in the same family, suggesting the presence of an autosomal dominant or recessive factor.…”

Section: Discussionmentioning

confidence: 99%

“Strabismus in children” is not simple – bilateral persistent hyperplasia primary vitreous: a case report

Zhang

2024

J Int Med Res

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Persistent hyperplastic primary vitreous (PHPV) is a rare congenital developmental ocular disorder caused by incomplete regression of the embryonic hyaloid vasculature; bilateral presentations are even rarer. We report a 6-year-old child with bilateral PHPV who visited our hospital for strabismus, without exhibiting leukocoria, microphthalmia, and systemic diseases. These unique characteristics distinguish our case from other cases of PHPV. It is crucial to increase awareness of congenital eye disease in children and the importance of performing fundus examination with the pupils dilated.

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Section: Discussionmentioning

confidence: 99%

“Strabismus in children” is not simple – bilateral persistent hyperplasia primary vitreous: a case report

Zhang

2024

J Int Med Res

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“…Pollard [ 3 ], in his study of 83 cases of PHPV, reported only two cases (2.4%) that had bilateral PHPV. Bilateral presentations are commonly associated with systemic and syndromic associations such as trisomy 13, 15, or 18, Norrie’s disease and Warburg’s syndrome [ 7 ]. However, no systemic anomalies were present in our patients.…”

Section: Discussionmentioning

confidence: 99%

Bilateral primary hyperplastic persistent vitreous: report of two cases

Singh

Agrawal

Mishra

2020

GMS Ophthalmology Cases; 10:Doc42

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“…Microphthalmia, leukocoria and cataract are the most common clinical findings. There are three types of PHPV, i.e., anterior, posterior and a combination of the two [ 12 ]. Depending on the severity of the case, complications like glaucoma, retinal detachment, intraocular hemorrhage, uveitis and phthisis bulbi could occur [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Unilateral Leukocoria in an Infant

Vasireddy¹,

Atwi²

2020

Cureus

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A nine-day-old male infant presents with his mother to the pediatric clinic with a concern of a white spot in his right eye. There was no history of antenatal or perinatal complications and the mother's serology was negative. Physical examination was remarkable only for leukocoria in the right eye. He was evaluated to have a Mittendorf dot. This is a benign clinical finding. Pupillary reflex check is an important part of a physical examination which can recognise pathological conditions such as cataract, retinoblastoma, metabolic errors with ocular manifestations and lead to early treatment before the child loses vision.

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Bilateral persistent hyperplastic primary vitreous: A rare entity

Cited by 8 publications

References 5 publications

“Strabismus in children” is not simple – bilateral persistent hyperplasia primary vitreous: a case report

“Strabismus in children” is not simple – bilateral persistent hyperplasia primary vitreous: a case report

Bilateral primary hyperplastic persistent vitreous: report of two cases

Unilateral Leukocoria in an Infant

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