Bilateral pneumatoceles resulting in spontaneous bilateral pneumothoraces and secondary infection in a previously healthy man with COVID-19

Natarajan, Preethi; Skidmore, James R.; Aduroja, Olufemi; Kunam, Vamsi; Schuller, Dan

doi:10.1080/08998280.2021.1927410

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…This is in contrast to Pyae and Arif, who described a similar case of a 64-year-old with COVID-19 complicated by pulmonary embolism that has delayed pneumothorax from pneumatocele rupture 20 days after hospitalization [ 11 ]. Our case report is similar to Natarajan et al, who described a 32-year-old firefighter who also developed bilateral pneumothoraces with evidence of pneumatoceles and secondary bacterial infection [ 12 ]. Our case is dissimilar as our patient had less severe illness, had expeditious recovery, and did not receive anti-IL-6 treatment.…”

Section: Discussionsupporting

confidence: 85%

Pop Goes the Lung: Bilateral Pneumothoraces Due to Delayed Pneumatocele Rupture in Coronavirus Disease 2019 (COVID-19)

Khiatah,

Frugoli,

Akl

et al. 2024

Cureus

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Worldwide medical and scientific communities are focusing on further understanding coronavirus disease 2019 (COVID-19) complications and its long-term impact on survivors. Pneumatocele cases are being reported more as a consequence of this virus and a cause of pneumothorax in certain patients. In this case vignette, we present a previously healthy male with COVID-19 symptoms who required hospitalization for hypoxia and who required readmission for bilateral pneumothorax from the delayed rupture of pneumatoceles. We describe this rare pathology and provide hypotheses for possible etiologies.

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Section: Discussionsupporting

confidence: 85%

Pop Goes the Lung: Bilateral Pneumothoraces Due to Delayed Pneumatocele Rupture in Coronavirus Disease 2019 (COVID-19)

Khiatah,

Frugoli,

Akl

et al. 2024

Cureus

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“…Pneumatocele is a rare complication in COVID-19 pneumonia [5][6][7][8]. A metaanalysis from Bao et al (2020) described the following atypical CT-scannings: bronchiectasis (5.42%, 95% CI: 0.02%-19.31%), pleural effusion (5.88%, 95% CI: 3.38%-8.73%), pericardial effusion (4.55%, 95% CI: 2.09%-7.90%), and lymphadenopathy (3.38%, 95% CI: 1.00%-6.86%), respectively, but no pnematoceles [9].…”

Section: Discussionmentioning

confidence: 99%

Large pneumatocele as a rare complication in SARS-CoV-2 infection of the lung

2022

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In this paper, we present a case of SARS-CoV2-Virus a non-vaccinated 54-year-old male admitted with COVID-19 pneumonia and respiratory insufficiency requiring high-flow oxygen supplementation. CT-scan of the lung revealed multifocal bilateral ground-glass opacities and – as a rare complication – a large pneumatocele in the middle of the posterior part of the left lower lobe. In order to treat the pneumatocele, a 10 F was placed into the cavity. The resulting pneumothorax was successfully treated with a 20 F chest tube over a 9-day period. The pneumatocele shrank only slightly. This case demonstrates a unique radiologic finding in COVID-19, which is likely the result of severe inflammation secondary to SARS-CoV-2 including an unfruitful attempt at depressurisation.

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Prognosis of Spontaneous Pneumothorax/Pneumomediastinum in Coronavirus Disease 2019: The CoBiF Score

Woo¹,

Kipkorir²,

Marza³

et al. 2022

JCM

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Objectives: Pneumothorax and pneumomediastinum are associated with high mortality in invasively ventilated coronavirus disease 2019 (COVID-19) patients; however, the mortality rates among non-intubated patients remain unknown. We aimed to analyze the clinical features of COVID-19-associated pneumothorax/pneumomediastinum in non-intubated patients and identify risk factors for mortality. Methods: We searched PubMed Scopus and Embase from January 2020 to December 2021. We performed a pooled analysis of 151 patients with no invasive mechanical ventilation history from 17 case series and 87 case reports. Subsequently, we developed a novel scoring system to predict in-hospital mortality; the system was further validated in multinational cohorts from ten countries (n = 133). Results: Clinical scenarios included pneumothorax/pneumomediastinum at presentation (n = 68), pneumothorax/pneumomediastinum onset during hospitalization (n = 65), and pneumothorax/pneumomediastinum development after recent COVID-19 treatment (n = 18). Significant differences were not observed in clinical outcomes between patients with pneumomediastinum and pneumothorax (± pneumomediastinum). The overall mortality rate of pneumothorax/pneumomediastinum was 23.2%. Risk factor analysis revealed that comorbidities bilateral pneumothorax and fever at pneumothorax/pneumomediastinum presentation were predictors for mortality. In the new scoring system, i.e., the CoBiF system, the area under the curve which was used to assess the predictability of mortality was 0.887. External validation results were also promising (area under the curve: 0.709). Conclusion: The presence of comorbidity bilateral pneumothorax and fever on presentation are significantly associated with poor prognosis in COVID-19 patients with spontaneous pneumothorax/pneumomediastinum. The CoBiF score can predict mortality in clinical settings as well as simplify the identification and appropriate management of patients at high risk.

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Bilateral pneumatoceles resulting in spontaneous bilateral pneumothoraces and secondary infection in a previously healthy man with COVID-19

Cited by 3 publications

References 6 publications

Pop Goes the Lung: Bilateral Pneumothoraces Due to Delayed Pneumatocele Rupture in Coronavirus Disease 2019 (COVID-19)

Pop Goes the Lung: Bilateral Pneumothoraces Due to Delayed Pneumatocele Rupture in Coronavirus Disease 2019 (COVID-19)

Large pneumatocele as a rare complication in SARS-CoV-2 infection of the lung

Prognosis of Spontaneous Pneumothorax/Pneumomediastinum in Coronavirus Disease 2019: The CoBiF Score

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