Bilateral premacular sub‐hyaloid hemorrhage‐unmasking COVID‐19 induced pancytopenia

Kumar, Ashok; Kumar, Poninder; Singh, Ankita; Dubbaka, Srujana; Kaushik, Jaya

doi:10.1002/jmv.26752

Cited by 5 publications

(7 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This dermatological manifestation has been reported in another case of COVID-induced panctyopaenia; 21 however, although a rare presenting symptom, spontaneous bleeding in an otherwise healthy individual can also be the first presentation. 20 Pancytopaenia can create dilemmas in the clinical management of COVID-19 particularly around interventions with increased bleeding risk, such as venous thromboembolism prophylaxis and performing invasive procedures such as arterial line and central venous cannulation where covered with blood products is likely to be required. As described in the literature, and this case report, management of COVID-19-induced pancytopaenia is primarily supportive.…”

Section: Discussionmentioning

confidence: 99%

“…Our report of de novo COVID-induced pancytopaenia is not unique. Several cases have been reported throughout the pandemic of de novo pancytopaenia in adults with no haematological conditions or risk factors for cytopaenia 17–20. Two cases of spontaneous bleeding (premacular subhyaloid haemorrhage20 and spontaneous haemoperitoneum21) in healthy male patients with no comorbidities have been reported as presenting symptoms of COVID-19-induced pancytopaenia.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

De novo pancytopaenia in an older adult with severe COVID-19 infection

2022

View full text Add to dashboard Cite

During the COVID-19 pandemic, it was recognised that SARS-CoV-2 can cause multisystem illness. Non-respiratory complications observed early in the pandemic were haematological in nature. A rare but serious haematological complication of COVID-19 infection is pancytopaenia. We describe a case of an older adult without pre-existing haematological disease or risk factors for cell dyscrasia with severe pancytopaenia induced by COVID-19, who developed critical illness requiring respiratory support in intensive care and died. Our case report highlights that de novo pancytopaenia may only present with mild dermatological manifestations and may indicate severe COVID-19 infection. Management is primarily supportive and early involvement of haematology should be sought.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

De novo pancytopaenia in an older adult with severe COVID-19 infection

2022

View full text Add to dashboard Cite

show abstract

“…[ 20 ] While bilateral simultaneous pre-foveal hemorrhage as a complication of post COVID-19 sepsis has not been reported, bilateral premacular sub-hyaloid hemorrhage unmasking COVID-19 infection has been reported. [ 21 ]…”

Section: Discussionmentioning

confidence: 99%

Retinal manifestations in patients following COVID-19 infection: A consecutive case series

Goyal

Murthy

Annum

2021

Indian Journal of Ophthalmology

View full text Add to dashboard Cite

Purpose: To describe retinal manifestations seen in patients associated with COVID-19 infection at a multi-specialty tertiary care hospital in Southern India. Methods: In this retrospective chart review, all consecutive cases presenting to the Retina-Uveitis service from May 2020 to January 2021 with retinal manifestations associated with COVID-19 infection or its sequelae or as a result of treatment given for COVID-19 were included. Results: Of the 7 patients, 3 were female, and 4 were male. Four patients had onset of symptoms during the active phase of COVID-19 infection. Four had bilateral and three had unilateral involvement. The manifestations ranged from mild to vision threatening. Vision threatening manifestations included infections: endogenous endophthalmitis, candida retinitis and tubercular choroidal abscess and bilateral pre-foveal hemorrhages. Milder manifestations included paracentral acute middle maculopathy, central serous chorio-retinopathy and voriconazole induced visual symptoms. Final visual acuity was 6/36 or better in the four severe cases and 6/9 or better in the mild cases. Conclusion: This study highlights the retinal manifestations associated with COVID-19 infection and its sequelae. As these patients presented with an association with COVID-19 (either during or after recovery), ophthalmologists should be vigilant and screen for such entities in case of complaints of visual symptoms or in the presence of systemic sepsis. The outcomes can be good with prompt and aggressive management.

show abstract

“…Generally, those affected with COVID-19 manifest with respiratory pathology, especially the classic bilateral multifocal pneumonia; less commonly, however, the infection affects the bone marrow, hindering the hematopoietic system. 1 This may lead to lymphopenia, neutropenia, and rarely pancytopenia. 2 , 3 The first case of persistent pancytopenia associated with SARS-CoV-2 bone marrow infiltration in an immunocompromised patient was described in October 2020, and subsequently other reports emerged.…”

Section: Introductionmentioning

confidence: 99%

Case Report: COVID Associated Pancytopenia Unmasking Previously Undiagnosed Pernicious Anemia

Barranco-Trabi

Minns

Akter

et al. 2022

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-associated pancytopenia is a known but rare complication of COVID-19 syndrome that is not well described in literature. Severe acute respiratory syndrome coronavirus 2 has shown the potential to affect any organ including the bone marrow, which then results in a decrease in all three blood cell lines. These cases usually resolve with the passage of time and treatment of underlying risk factors. As COVID pneumonia rates continue to increase worldwide, it is crucial to be able to recognize this complication. Additionally, deeper investigation into patient’s response to COVID infection can be complicated by unexpected underlying disease. We report a case of a symptomatic 24-year-old active duty male in Hawaii with post-COVID pancytopenia that was found to have previously undiagnosed pernicious anemia and his response to standard treatment.

show abstract

Bilateral premacular sub‐hyaloid hemorrhage‐unmasking COVID‐19 induced pancytopenia

Cited by 5 publications

References 7 publications

De novo pancytopaenia in an older adult with severe COVID-19 infection

De novo pancytopaenia in an older adult with severe COVID-19 infection

Retinal manifestations in patients following COVID-19 infection: A consecutive case series

Case Report: COVID Associated Pancytopenia Unmasking Previously Undiagnosed Pernicious Anemia

Contact Info

Product

Resources

About