Bilateral Primary Adrenal Non-Hodgkin Lymphoma

Erçolak, Vehbi; Kara, Oǧuz; Günaldı, Meral; Afşar, Çiğdem Usul; Duman, Berna Bozkurt; Acikalin, Arbil; Ergïn, Melek; Erdoğan, Şeyda

doi:10.4274/tjh.2013.0195

Cited by 11 publications

(9 citation statements)

References 9 publications

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“…On the whole, currently available therapeutic options mainly include surgical excision, radiotherapy, chemotherapy, and targeted therapy. It was important to note that primary adrenal lymphoma was rare, accounting for < 1% of non-Hodgkin lymphomas, furthermore, the most common category was diffuse large B cell lymphoma (DLBCL) [26][27][28] , which was the same as our outcome. There was still no consensus on the treatment of primary adrenal lymphoma.…”

Section: Discussionsupporting

confidence: 66%

Summary of clinical characteristics of common primary adrenal malignancies in adults

zhang¹,

wang²,

Li³

et al. 2020

Preprint

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Background To summary the clinical characteristics of common primary adrenal malignancies in adults, the survival time of the patients, and the prognostic factors associated with these rare malignancies. Methods The Surveillance, Epidemiology, and End Results database (1975–2016) was queried for all patients who were diagnosed with primary adrenal malignancies, including adrenocortical carcinoma(ACC), pheochromocytoma and paraganglioma (PPGL), lymphoma, and sarcoma (SA). The clinical characteristics, overall survival (OS) and cancer-specific survival (CSS) were analyzed, in which propensity score methodology, logistic regression modeling and Kaplan-Meier survival curves were used. The Multivariate Cox proportional hazard model was used to identify factors affecting the prognosis of patients with ACC. Results 3204 patients with primary adrenal malignancies were identified, including 2180 with ACC, 593 with PPGL, 307 with lymphoma, and 124 with SA. Generally, PPGL had a better prognosis than others. For ACC and PPGL, the non-metastatic group had better OS and CSS than the metastatic group; for SA, the non-metastatic group had better OS, however, there was no significant difference in CSS between the two groups. Furthermore, For ACC, the single metastasis group had a better OS than the multiple metastasis group. After tumors metastasis, the surgery group, surgery of primary adrenal lesions, had better OS and CSS than the non-surgery group for ACC and PPGL. For lymphoma, the chemotherapy group had better OS and CSS; for ACC and PPGL, the chemotherapy group had better CSS and worse OS; for SA, the survival showed no significant difference between the two groups. Radiotherapy had the same effect on patients' survival as chemotherapy, except for the lymphoma and the ACC. As for lymphoma, the radiotherapy group had better CSS, whereas the survival showed no significant difference in OS between the two groups. For ACC, the non- radiotherapy group had better CSS and OS. More importantly, for lymphoma, under the condition that both cohorts were the same basically, the surgical group had a better prognosis. The prognosis of ACC was related to sex, age, seer historic stage, surgery, chemotherapy. Conclusion Understanding the clinical characteristics of these tumors and factors affecting prognosis can facilitate the selection of more appropriate clinical treatment options.

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Section: Discussionsupporting

confidence: 66%

Summary of clinical characteristics of common primary adrenal malignancies in adults

zhang¹,

wang²,

Li³

et al. 2020

Preprint

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“…Only 100 case had been reported in the literature (9). Primary adrenal lymphomas are typically seen in elders and males, and 70% of the case are bilateral (10,11). According to previous studies, male/female ratio is 7:1 and mean age at the time of diagnosis is 70 years (12,13).…”

Section: Discussionmentioning

confidence: 99%

Small İntestine İntussusception Accompanying With Bilateral Adrenal Mass In A 11 Years Old Child With Burkitt Lymphoma

Sarişik¹,

Acıpayam²,

Güler³

et al. 2020

Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi

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Gastrointestinal tract is one of the most common extranodal site involved by non-Hodgkin lymphomas. However, Non-Hodgkin lymphomas are seen less in the small intestine. We present here a rare condition inthe literature which is a case of bilateral adrenal masses and Burkitt lymphoma with small intestine origin. Eleven years old male patient was admitted to pediatric emergency service with acute abdomen. Abdominal USG examination revealed intussusception and bilateral adrenal masses. Emergency surgery was planned. In the surgical operation, five lesions were seen in the small intestine. Partial small intestine resection was performed. The patient was diagnosed as Burkitt Lymphoma with small bowel origin due to pathology of resection material. Non-hodgkin lymphomas with small intestine origin usually present with abdominal pain, and their prognosis depends on histological type and grade. NHL-BFM 95 chemotherapy treatment was initiated and a good clinical response was achieved, and the patient remained in complete remission for two months after completion of chemotherapy. In conclusion, Bilateral adrenal masses remain a rare form of Burkitt lymphoma and care must be taken in ruling out other causes of bilateral adrenal masses. Furthermore, with this case, we emphasize that Burkitt lymphoma should be considered in differential diagnosis of bilateral adrenal masses.

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“…PAL typically occurs in elderly and male, and ~70% of cases are bilateral (4,7,8). According to previous studies, the male to female ratio is 7:1 and the average age at diagnosis is 70 years old (9)(10)(11).…”

Section: Discussionmentioning

confidence: 99%

“…As a type of extranodal lymphoma, PAL is rare and constitutes <1% of cases of extranodal lymphomas; PAL is primarily bilateral but secondary involvement of the adrenal gland is typically unilateral (2,3). Diffuse large B cell lymphoma (DLBCL) is the most common subtype of PAL, which represents ~70% of PAL cases (4,5). Characteristically, PAL predominantly affects elderly patients without nodular lesions.…”

Section: Introductionmentioning

confidence: 99%

Bilateral primary adrenal diffuse large B cell lymphoma without adrenal insufficiency: A case report and review of the literature

Chen

Jin

et al. 2017

Molecular and Clinical Oncology

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Abstract. Primary adrenal lymphoma (PAL) is an infrequent malignant tumor, occurring in the bilateral adrenal glands as a mass in the majority of cases. The current study presents a case of bilateral primary adrenal diffuse large B cell lymphoma in a 52-year-old female patient, who presented with abdominal pain in the left lumbar region for ~2 weeks. Abdominal ultrasound examination and computed tomography scanning revealed a mass of 132x119x101 mm on the left adrenal gland and a mass of 53x27 mm on the right adrenal gland. A percutaneous biopsy was performed and histopathological examination further confirmed this lesion as diffuse large B cell lymphoma. The present study highlights the importance of early diagnosis of PAL, and performs a literature review of the subject. IntroductionAlthough the adrenal glands contain no lymphoid tissue, primary adrenal lymphoma (PAL) is identified in <1% of cases of non-Hodgkin lymphoma (1). As a type of extranodal lymphoma, PAL is rare and constitutes <1% of cases of extranodal lymphomas; PAL is primarily bilateral but secondary involvement of the adrenal gland is typically unilateral (2,3). Diffuse large B cell lymphoma (DLBCL) is the most common subtype of PAL, which represents ~70% of PAL cases (4,5). Characteristically, PAL predominantly affects elderly patients without nodular lesions. Diagnosis of PAL is frequently challenging due to its nonspecific clinical manifestation and imaging results, and pathological examination is the only method of confirming this diagnosis (6). The prognosis of PAL is typically poor, and the 1-year survival rate is 17.5% (3). The current study reports a case of bilateral primary adrenal diffuse large B cell lymphoma and performs a review of the literature. Case reportIn June 2016, a 52-year-old female patient was admitted to the Department of Urology of Peking University Shenzhen Hospital (Shenzhen, China) due to abdominal pain in the left lumbar region lasting ~2 weeks. The patient had experience anorexia and weight loss of ~15 kg in the previous 0.5 months. The patient's past medical history included grade one hypertension for ~3 years and cerebral infarction ~2 years previously. On admission, physical examination revealed that no enlarged superficial lymph nodes were palpable and there was no hepatosplenomegaly. A full blood count revealed that had a hemoglobin level of 91 g/l (normal range, 115-150 g/l), a white blood cell count of 5.45x10 9 /l (normal range, 3.5-9.5x10 9 /l), 55.2% neutrophils (normal range, 40-75%), 27.2% lymphocytes (normal range, 20-50%), 13.8% monocytes (normal range, 3-10%), 3.1% eosinophils (normal range, 0.4-8%), 0.7% basophils (normal range, 0-1%), and a platelet count of 449x10 9 /l (normal range, 125-350x10 9 /l). A biochemical profile revealed a potassium level of 2.8 mmol/l (normal range, 3.5-5.3 mmol/l), a sodium level of 138 mmol/l (normal range, 137-147 mmol/l), an albumin level of 33.7 g/l (normal range, 40-55 g/l), a uric acid level of 558 µmol/l (normal range, 155-357 µmol/l), triglyceride levels of 2...

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Bilateral Primary Adrenal Non-Hodgkin Lymphoma

Cited by 11 publications

References 9 publications

Summary of clinical characteristics of common primary adrenal malignancies in adults

Summary of clinical characteristics of common primary adrenal malignancies in adults

Small İntestine İntussusception Accompanying With Bilateral Adrenal Mass In A 11 Years Old Child With Burkitt Lymphoma

Bilateral primary adrenal diffuse large B cell lymphoma without adrenal insufficiency: A case report and review of the literature

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