Bilateral Pulmonary Nodules Due to Brucellosis

López, Sebastián Sevilla; Valenzuela, Florencio Quero; Fernández, Inmaculada Piedra

doi:10.1016/j.arbr.2011.02.001

Cited by 4 publications

(5 citation statements)

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“…In this study, especially 40 to 59 years old, most of them were adult male herders, about twice as many women, which showed a fantastic resemblance to Pappas G et al [16]. And Sevilla López S et al [17] agreed with our conclusion too. The contaminated aerosols may be responsible for it [3].…”

Section: Discussionsupporting

confidence: 91%

“…To our knowledge, there were a few documents that mentioned PB by far and the symptoms like fever, fatigue, loss of appetite, pectoralgia, chronic cough and chest pain were usually reported [20]. The previous studies concerning brucellosis consented to our ndings [9,17,21,22]. It is noteworthy that only a minor part of our study patients got troubled with chest symptoms, which led to missed diagnosis without radiological examination.…”

Section: Discussionmentioning

confidence: 66%

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Pulmonary Brucellosis in Xinjiang, China: A Retrospective Study of 38 Cases and Review of the Literature

Lan

Chen

et al. 2022

Preprint

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Background: Pulmonary brucellosis (PB) is a unique infection caused by Brucella and it is challenging to diagnose PB accurately for its diverse clinical manifestations. We tried to summarize PB’s features to enhance our awareness of it and offer differential diagnoses in endemic zones by evaluating their demographic characteristics, clinic data, and imaging findings.Methods: The demographic characteristics, clinic data and the imaging findings of 38 patients with PB from January 2011 to January 2020 in Xinjiang Medical University Affiliated First Hospital were presented. Results: The median age were 51 years. The most common clinical manifestations were fever (73.7%). The laboratory data decreased significantly, containing hematocrit (84.2%), hemoglobin (78.9%), red blood cell count (65.8%), eosinophilic count (47.3%). On computed tomography (CT), 27 patients had nodules, 23 (60.5%) interstitial infiltration, 16 (42.1%) consolidation, 15 (39.5%) patchy shadow, and 7 (18.4%) atelectasis. 11 patients had pleural thickening and 10 (26.3%) patients suffered from hydrothorax. 20 (52.6%) patients had lymphadenectasis in the hilum of lung or mediastinum, three pericardial effusion, and 1 pericardial thickening. Conclusion: PB should not be excluded when a patient has chest radiologic abnormalities, meanwhile complain of an atypical high fever and fatigue, especially in the epidemic region.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 66%

Pulmonary Brucellosis in Xinjiang, China: A Retrospective Study of 38 Cases and Review of the Literature

Lan

Chen

et al. 2022

Preprint

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“…These include respiratory ( 4 ), ocular ( 12 ), nerve ( 13 ), and reproductive systems ( 14 ). Regarding respiratory involvement, brucellosis can present with bronchitis, pleural effusion, and pulmonary nodules ( 15 – 17 ). These symptoms may be directly caused by the transmission of bacteria through the respiratory tract to the respiratory system, or they can be caused by the transmission of bacteria through the blood after infecting the human body in other ways ( Figure 3 ).…”

Section: Discussionmentioning

confidence: 99%

Case report: Brucellosis with rare multiple pulmonary nodules in a depressed patient

Zhou

Wang²,

Liu³

et al. 2023

Front. Med.

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BackgroundBrucellosis is a zoonotic disease that threatens public health and creates an economic burden. Unfortunately, it is often overlooked in developing countries, with misdiagnosis causing negative impacts on those with low income. Although the symptoms of brucellosis are commonly reported as fever and fatigue, rare pulmonary, and psychiatric involvements should also be considered. We present the first brucellosis patient in China with multiple pulmonary nodules and depression. Furthermore, this report highlights the importance of collecting patient history in epidemic areas of brucellosis.Case presentationWe report the case of a 40-year-old woman with intermittent fever for 2 months and gradually accompanied by chills, dry cough, arthralgia, and fatigue. The patient was also diagnosed with depression after fever. She received symptomatic treatment at a regional hospital; however, there was no significant symptom relief. She suddenly developed hemoptysis 1 day prior to arrival at our hospital, where we discovered that her liver, spleen, neck, and axillary lymph nodes were enlarged, and there were multiple nodules in both lungs. The patient was eventually diagnosed with brucellosis after the serum agglutination test and received antibiotic therapy, which provided symptom relief.ConclusionThis report describes a case of brucellosis with uncommon multipulmonary nodules and depression in China. This study has widened the evidence of respiratory involvement due to brucellosis. Second, it demonstrates the importance of collecting a comprehensive medical history, especially in epidemic areas. In conclusion, for febrile patients with pulmonary nodules and depression, especially in endemic areas, brucellosis should be considered.

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“…In pulmonary nodules complicated by brucellosis, patients may present with bilateral pulmonary nodules on chest radiographs and CT, in addition to chest pain (Sevilla Loṕez et al, 2011). Brucellosis can also be complicated by pleural effusion, and in addition to the typical symptoms of pleurisy, such as chest pain, patients may present with cough and dyspnea.…”

Section: Respiratory Systemmentioning

confidence: 99%

Research progress on complications of Brucellosis

Jun

Fan

Gao

et al. 2023

Front. Cell. Infect. Microbiol.

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Brucellosis is a common zoonotic disease that is widely spread worldwide and poses a major threat to human health. Clinically, it often presents with non-specific symptoms such as fever, excessive sweating, malaise, myalgia, arthralgia, loss of appetite, weight loss, and enlarged liver, spleen and lymph nodes. The disease has a long and recurrent course, often accumulating in multiple systems and organs. Of these, osteoarticular involvement is the most common complication, with a prevalence of approximately 2-77%, usually manifesting as spondylitis, sacroiliac arthritis and peripheral arthritis. Hepatosplenomegaly is seen in about 50% of patients with brucellosis, and gastrointestinal disturbances such as abdominal pain, nausea, and vomiting are common. Although respiratory involvement is less common, pneumonia, pleurisy, pleural effusion, and pulmonary nodules have been reported. Besides, approximately 2-20% of cases involve infections of the male genitourinary system, mainly manifesting as unilateral epididymal-orchitis and orchitis. The most serious complication facing brucellosis is cardiovascular involvement, and although the overall mortality rate of brucellosis is about 1% and the incidence of brucellosis endocarditis is less than 2%, more than 80% of deaths are associated with endocarditis. Furthermore, brucellosis is complicated by hematologic disease, with anemia occurring in approximately 20-53% of children during the acute phase. In addition, the neurological incidence of brucellosis is about 0.5-25%, mainly manifested as meningitis. In this study, we review the multisystem complications of brucellosis with the aim of improving early diagnosis, timely treatment and prevention of long-term complications.

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Bilateral Pulmonary Nodules Due to Brucellosis

Cited by 4 publications

References 5 publications

Pulmonary Brucellosis in Xinjiang, China: A Retrospective Study of 38 Cases and Review of the Literature

Pulmonary Brucellosis in Xinjiang, China: A Retrospective Study of 38 Cases and Review of the Literature

Case report: Brucellosis with rare multiple pulmonary nodules in a depressed patient

Research progress on complications of Brucellosis

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