Bilateral renal and jejunal metastasis of choriocarcinoma presenting as spontaneous renal hemorrhage

Lal, Anupam; Singhal, Monisha; Kumar, Suresh; Bag, Sanand; Singh, Sunil Kumar; Khandelwal, Niranjan

doi:10.1102/1470-7330.2009.0010

Cited by 15 publications

(13 citation statements)

References 3 publications

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“…It has well recognized that in postmenopausal woman, the possibility of pregnancy was very rare, according to above mentioned, assessment of serum bhcG as a first priority has seldom considered. Few cases of choriocarcinoma that developed after a long latent period from a previous pregnancy have reported ( 19 , 20 ). However, due to delayed diagnosis of choriocarcinoma, these patients have admitted in advance stage.…”

Section: Discussionmentioning

confidence: 99%

Abnormal Presentation of Choriocarcinoma and Literature Review

et al. 2016

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IntroductionGestational trophoblastic neoplasms have highly been malignant potential, which usually occurred in child-bearing age women. Unusual feature of this malignancy would be rare, it was important to take in mind the possibility of GTN in different manifestation. Based on the above mentioned, the aim of this presentation would be the management and outcome of a case series of choriocarcinoma patients with abnormal manifestation.Case PresentationWe have presented four patients, first who initially manifestation with signs of septic shock, the second case with severe gastrointestinal hemorrhage, the third case with postpartum infection and the forth case was a postmenopausal bleeding patient.ConclusionsIn case of metastatic choriocarcinoma with precise history, accurate diagnosis and appropriate treatment have led us to curable results.

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Section: Discussionmentioning

confidence: 99%

Abnormal Presentation of Choriocarcinoma and Literature Review

et al. 2016

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“…A few patients with renal lesions that were unresponsive to chemotherapy had their kidney lesion excised in the presence of an isolated renal mass ( Figures 2A,B ), and unilateral nephrectomy was applicable when multiple metastatic lesions were present, causing loss of the normal shape of the kidney ( Figure 2C ). In a small number of cases, when GTN patients present spontaneous renal hemorrhage, angioembolization can be performed for hemorrhage control ( 13 ). In this study, two patients underwent unilateral nephrectomy and one underwent renal artery embolization for bleeding control.…”

Section: Discussionmentioning

confidence: 99%

Gestational Trophoblastic Neoplasia With Urinary System Metastasis: A Single Center Experience

et al. 2020

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Background: Gestational trophoblastic neoplasia (GTN) with urinary system metastasis is rare. There is limited information about this situation. This study aimed to analyze clinical features, prognostic factors, and survival outcomes of patients with metastasis to the urinary system arising from GTN. Methods: Medical records of 53 consecutive GTN patients with urinary system metastases and treated at Peking Union Medical College Hospital (PUMCH) between 1990 and 2018 were reviewed. The Kaplan-Meier survival analysis was used to describe the overall survival. Prognostic factors were identified using univariate and multivariate analyses. Results: Fifty-three GTN patients with urinary tract metastasis were identified in our institution. The mean age of patients was 30.8 years (range, 23–53 years). Thirty-six (67.9%) patients achieved complete remission (CR), and the remaining 17 (32.1%) showed progressive disease. The 5-year overall survival rate of the entire cohort was 78.4%. Age ≥ 40 years was an independent risk factor for prognosis (HR 12.353, 95% CI 2.203-69.261, P = 0.004). Previous failed chemotherapy history ( P = 0.040) and the presence of brain and/or liver metastases ( P = 0.024) significantly influenced the survival of GTN patients with urinary tract system metastasis. Conclusion: GTN with urinary tract metastasis is a rare condition. Patients with different metastatic sites have different CR rates and prognosis. Therefore, individualized strategies should be considered for patients with different metastatic sites. Urinary system metastasis is probably not a prognostic factor in GTN patients. Patients aged ≥40, those who had previous failed multidrug chemotherapy, and presented brain and/or liver metastases showed a significant adverse outcome.

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“…The patient’s condition was further complicated with simultaneous jejunal metastasis, nosocomial pneumonia that led to sepsis and death. 4 Antiplatelet drug therapy might also play a role as a contributing factor possibly more so during pregnancy. 5 Other factors include anticoagulation, nonsteroidal anti-inflammatory drugs, cystic diseases, blood dyscrasia, hypertension, hemodialysis, post-lithotripsy, or ureterorenoscopy.…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Spontaneous Bilateral Subcapsular Renal Hematoma

Bajaj

Trang

Nasrawi

et al. 2020

Journal of Investigative Medicine High Impact Case Reports

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Spontaneous bilateral renal subcapsular hematoma is a rare condition. On literature review, only 2 case reports have elucidated possible etiologies for such a presentation; however, no definite conclusions have been made. We present a rare case of a 52-year-old female with diabetes mellitus type 2, chronic kidney disease stage 4, hypertension, hyperlipidemia, prior traumatic brain injury via motor vehicle accident, who presented to our hospital with diabetic ketoacidosis and clinical signs of pyelonephritis; subsequently, imaging demonstrated spontaneous bilateral renal subcapsular hematoma. Risk factors for the rare presentation in this patient included pyelonephritis, history of bilateral ureteral stent placement, and a remote history of a mild unilateral renal laceration secondary to a motor vehicle accident. Typically, patients with this condition achieve spontaneous resolution with conservative management. Our patient initially presented with diabetic ketoacidosis and pyelonephritis but gradually developed retroperitoneal bleeding and hemorrhagic shock. Our patient’s critical condition required close monitoring in an intensive care unit and a more invasive approach including unilateral left renal artery embolization followed by a unilateral left nephrectomy. The patient ultimately recovered and continued to be followed outpatient without any serious long-term complications.

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Bilateral renal and jejunal metastasis of choriocarcinoma presenting as spontaneous renal hemorrhage

Cited by 15 publications

References 3 publications

Abnormal Presentation of Choriocarcinoma and Literature Review

Abnormal Presentation of Choriocarcinoma and Literature Review

Gestational Trophoblastic Neoplasia With Urinary System Metastasis: A Single Center Experience

A Rare Case of Spontaneous Bilateral Subcapsular Renal Hematoma

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