Bilateral Renal Choriocarcinoma in a Postmenopausal Woman

Abstract

Choriocarcinoma is the most malignant tumor of gestational trophoblastic neoplasia. It grows rapidly and metastasizes to the lung, liver, and less frequently, the brain. Metastases to the kidney are rare in the literature, and bilateral involvement is even more scarce. Renal involvement of choriocarcinoma is highly exceptional and may mimic renal cell carcinoma. Here we report a case of bilateral renal choriocarcinoma presenting 5 years after a history of a total anterior hysterectomy because of a hydatidiform mole.

Spontaneous bleeding from an unusual renal mass: A case of gestational choriocarcinoma related to previous pregnancy over a decade earlier

“…The aggressive nature of this disease in this patient, with spontaneous bleeding and rapidly evolving metastases, is consistent with previously reported cases of renal metastases 2 , 3 . This patient demonstrated an excellent response to chemotherapy, which is similar to previously reported gestational choriocarcinoma cases 2 , 3 .…”

“…Choriocarcinoma is a rare but highly malignant trophoblastic neoplasm that often progresses very rapidly and can be classified as either gestational or non-gestational in origin. 1 , 2 Non-gestational choriocarcinoma originates from germ cells of either the gonad or rarely extragonadal germ cells, while gestational choriocarcinoma only occurs in women and usually occurs after a complete hydatiform mole, spontaneous abortion or normal pregnancy. 1 It most frequently originates in the uterus and is known to metastasise haematogenously and most commonly to the vagina, lung or brain.…”

Abnormal Presentation of Choriocarcinoma and Literature Review

“…Primary or metastatic choriocarcinomas of the cervix, small bowel, kidneys and post-menopausal were infrequent ( 7 , 8 ). The aim of this presentation was the management and outcome of a case series of choriocarcinoma patients with abnormal manifestation.…”

Gestational choriocarcinoma in a postmenopausal woman. A case report and literature review

“…Other uncommon sites of chorioncarcinoma metastasis and very rare locations are as follows: in skin 1.4-5%, choroid, uvea, maxillary sinus, intranasal area and also in solid organ transplants, like kindey and liver [14,[32][33][34][35].…”

“…Gestational trophoblastic neoplasia occurs most commonly in reproductive age after antedecent gestational events, like recent pregnancy usually within a year of a preceding pregnancy or more decades in the past, molar or non-pregnancy in 50% of the cases, abortions, ectopic pregnancies also recently or after a long time in the past, while only a few cases have been reported in the international literature. In complete molar pregnancies the classical occurrence of large edematosus clusters of vesicles with hemorrhage and necrosis is typical [14,[32][33][34][35]. The majority karyotype of complete molar pregnancies are 46XX in 95% of cases arise arising from fertilization of an empty pronucleus by haploid sperm that undergoes duplication, Diandric diploidy, while the minority are 46 XY in 5% of cases which arise from fertilization of an empty egg by two sperm and led to Diandric dispermy.…”