Bilateral renal malacoplakia in systemic lupus erythematosus and adrenogenital syndrome

Mohácsi, G; Julesz, J.; Berger, Zoltán; Ormos, J

doi:10.1007/bf02549899

Cited by 7 publications

(1 citation statement)

References 23 publications

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“… 1 It is recently described in renal transplant recipients and cancer patients receiving chemotherapy. 2–4 We report a first case of malakoplakia in a systemic sclerosis patient.…”

Section: Introductionmentioning

confidence: 92%

Bladder Malakoplakia in Systemic Sclerosis Patient: A Case Report and Review Literature

Sirithanaphol

Sangkhamanon

Netwijitpan

et al. 2018

Journal of Endourology Case Reports

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Malakoplakia, an anecdotal reactive granulomatous lesion, is a rare pathologic entity but relatively more common in genitourinary tracts. Here we report a case of malakoplakia in the urinary bladder in systemic sclerosis. The patient was a 66-year-old female treated with long-term corticosteroid and cyclophosphamide. She presented with gross hematuria, and cystoscopy and biopsy revealed malakoplakia. There was no tumor and the stains for infectious organism were all negative. To the best of our knowledge, this is the first case report of malakoplakia in a systemic sclerosis patient.

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“… 1 It is recently described in renal transplant recipients and cancer patients receiving chemotherapy. 2–4 We report a first case of malakoplakia in a systemic sclerosis patient.…”

Section: Introductionmentioning

confidence: 92%

Bladder Malakoplakia in Systemic Sclerosis Patient: A Case Report and Review Literature

Sirithanaphol

Sangkhamanon

Netwijitpan

et al. 2018

Journal of Endourology Case Reports

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Malacoplakia. Two case reports and a comparison of treatment modalities based on a literature review

Voort

Velden²,

Wassenaar³

et al. 1996

Archives of Internal Medicine

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Malacoplakia is a rare infectious disease that has been almost exclusi vely reported in urology and pathology journals. We studied two cases of malacoplakia that were primarily referred to the department of internal medicine because of fever and abdominal masses. In one patient, malacoplakia was diagnosed in the unusual ovarian location, while in the other patient a large renal mass was found and ciprofloxacin therapy failed because of bacterial resistance. The clinical and radiologic appearance of malacoplakia often mimics that of a malignant tumor. The principal disorder is probably a monocytic-macrophagic bactericidal defect. A definitive diagnosis depends on microscopic detection of Michaelis-Gutmann bodies by means of von Kossa stain. We outlined treatment strategies on the basis of a review of the literature since 1981, which included 140 cases. If possible, immunosuppressive drugs should be stopped. Quinolone antibiotic treatment and surgical excision or incision and drainage lead to the highest cure rates (90% and 81%, respectively). Specific intracellular penetration of quinolone antibiotics is a possible reason for the higher cure rate achieved with these antibiotics. Bethanechol has been suggested to correct the supposed fundamental disturbance by increasing the intrecellular cyclic guanosine monophosphate concentration, but there is still no convincing evidence of its clinical efficacy.

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Renal parenchymal malakoplakia ?a case report and review of the literature

et al. 1993

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Malakoplakia is an inflammatory condition associated with persisting bacterial antigen in macrophages and characterized histologically by the Michaelis-Gutmann body, containing bacterial fragments. We review the pathogenesis of malakoplakia and report a novel form of treatment successfully used in an 8-week-old infant with bilateral renal malakoplakia. The patient presented with an acute Escherichia coli urinary tract infection and enlarged kidneys. Antibiotic regimes were ineffective, but once the diagnosis was made treatment was changed to an immunosuppressive regime of prednisolone and azathioprine, to which she responded promptly. Renal malakoplakia should be considered in any patient with a urinary tract infection unresponsive to antibiotics and enlarged kidneys. Although a large proportion of patients with malakoplakia have an underlying systemic disorder, which may account for their abnormal macrophage function, the rest demonstrate either an isolated macrophage defect or no detectable anomaly at all. It is in this latter group we suggest that an immunomodulating regime can be curative.

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Bilateral renal malacoplakia in systemic lupus erythematosus and adrenogenital syndrome

Cited by 7 publications

References 23 publications

Bladder Malakoplakia in Systemic Sclerosis Patient: A Case Report and Review Literature

Bladder Malakoplakia in Systemic Sclerosis Patient: A Case Report and Review Literature

Malacoplakia. Two case reports and a comparison of treatment modalities based on a literature review

Renal parenchymal malakoplakia ?a case report and review of the literature

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