Bilateral retiform variant of sertoli leydig cell tumour of ovary: An uncommon tumor with review of literature

Rathi, Monika; Budania, Satish Kumar; Khalid, Mohammad; Mittal, Ankur

doi:10.4103/0976-7800.153625

Cited by 5 publications

(15 citation statements)

References 7 publications

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“…Our review of the literature revealed 29 previously published cases of bilateral ovarian SLCT (Tables 1 and 2) 14,19–42 ; two of these are included in this study (cases 2 and 3 in Table 1). Where possible, the articles and the photomicrographs were reviewed to try to determine the type of SLCT; this was sometimes difficult, given a paucity of pathological description and photomicrographs.…”

Section: Resultsmentioning

confidence: 99%

Somatic tumour testing establishes that bilateral DICER1‐associated ovarian Sertoli–Leydig cell tumours represent independent primary neoplasms

et al. 2020

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Aims Sertoli–Leydig cell tumours (SLCTs) are rare ovarian neoplasms that are commonly associated with somatic or germline DICER1 mutations, especially when of the moderately or poorly differentiated type. A large majority are unilateral, but bilateral neoplasms have been reported, sometimes in the context of germline DICER1 mutations (DICER1 syndrome). It is currently unknown whether these represent independent neoplasms or metastasis from one ovary to the other and we aimed to elucidate this. Methods and results We report three cases of bilateral ovarian SLCT (all in patients with DICER1 syndrome) and review all reported cases of bilateral neoplasms. In the three cases (all moderately or poorly differentiated neoplasms), the time interval between the discovery of the tumours in each ovary ranged from 2.7 years to 6 years. In all cases, different DICER1 somatic hotspot mutations within the two tumours provided definitive proof that they represent independent neoplasms; this may be important clinically. Our literature review revealed that, when this information was available, all patients with bilateral SLCT had a germline DICER1 mutation. Conclusions Bilateral ovarian SLCTs represent independent rather than metastatic neoplasms, and essentially always occur in the context of DICER1 syndrome.

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Section: Resultsmentioning

confidence: 99%

Somatic tumour testing establishes that bilateral DICER1‐associated ovarian Sertoli–Leydig cell tumours represent independent primary neoplasms

et al. 2020

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“… 3 , 5 Most SLCTs were unilateral, and a tiny minority were bilateral. 7 , 8 Androgen overproduction always causes hirsutism, acne, deepening of the voice, breast atrophy, and clitorimegaly in SLCT patients. 2 In our study, patients showed irregular menstruation, hirsutism, acne, rougher voice, and breast development stagnation.…”

Section: Discussionmentioning

confidence: 99%

“…Heterologous components occur in nearly 20% of SLCTs, including gastric epithelium, retinal tissue, cartilage, or carcinoid tumors. 7 , 8 , 10 As a part of SLCTs, Leydig cells scatter among numerous Sertoli cells, arranging into open or closed tubules. Leydig cells are derived from the original mesenchyme of the mesonephros, and can produce and secrete testosterone, 11 making SLCTs functional ovarian tumors.…”

Section: Discussionmentioning

confidence: 99%

Imaging, clinical, and pathologic findings of Sertoli-leydig cell tumors

et al. 2021

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To explore the clinical features, imaging findings, and pathological manifestations of ovarian Sertoli-Leydig cell tumors (SLCTs). The clinical and pathological manifestations, tumor location, size, morphology, vascularity, computed tomography (CT) density, magnetic resonance imaging (MRI) signal intensity, and contrast enhancement patterns in five cases with SLCTs were retrospectively reviewed. SLCTs most commonly occurred in young women. Virilization was observed in three cases (60%). All five tumors were unilateral and oval or round, with a clear boundary. The solid part of the tumor was isoattenuated on the conventional CT scan, and showed isoattenuation or slight hypoattenuation relative to adjacent myometrium on T1 weighted imaging (T1WI) and T2 weighted imaging (T2WI). On contrast-enhanced images, three tumors showed marked enhancement. DICER1 hotspot mutations were commonly seen in SLCTs. A highly vascularized mass with low signal intensity (SI) of the solid part on T2WI and androgen overproduction symptoms may suggest an SLCT.

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“…As seen in our cases, those tumors have usually unilateral localization; but in rare cases bilateral localizations have also been reported. 4,5 Clinical signs and symptoms comprising secondary amenorrhea and varying degrees of virilization are dependent on the testosterone produced by tumor cells. 6 Rare estrogenic findings may also be observed.…”

Section: Discussionmentioning

confidence: 99%

Sertoli-Leydig Cell Tumor

Erhan¹,

Sayılgan²,

Şişman³

et al. 2019

Turkiye Klinikleri J Case Rep

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athological diagnosis of ovarian tumors seen in young adults is quite difficult. Sertoli-Leydig cell tumor (SLCT), a rare ovarian sex-cord stromal tumor should always be kept in mind in young cases of ovarian masses, since, beside its broad spectrum differential diagnosis and various variants, distinctive histological grades can complicate the diagnosis as well. 1,2 In this study three distinct SLCT cases, a well-differentiated, of intermediate differentiation and that with a retiform component were reported, emphasizing their differential diagnoses. Additionally we aimed to introduce an interesting clinical presentation of this tumor as seen in our third case with a retiform component which had a thyroid neoplasm. CASE REPORTS CASE 1 A 32 year-old woman admitted to emergency clinic with abdominal pain, nausea and vomiting lasting for 3 days. On physical examination, an appendectomy incision scar at the right lower quadrant and rebound tenderness at the left lower quadrant were observed. On the abdominal computed tomography scan of the patient with a preliminary diagnosis of acute abdomen, a hypodense cystic lesion of 67x50 mm and another hypodense cystic lesion of 1,2 cm of diameter were detected in the left and right Douglas

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Bilateral retiform variant of sertoli leydig cell tumour of ovary: An uncommon tumor with review of literature

Cited by 5 publications

References 7 publications

Somatic tumour testing establishes that bilateral DICER1‐associated ovarian Sertoli–Leydig cell tumours represent independent primary neoplasms

Somatic tumour testing establishes that bilateral DICER1‐associated ovarian Sertoli–Leydig cell tumours represent independent primary neoplasms

Imaging, clinical, and pathologic findings of Sertoli-leydig cell tumors

Sertoli-Leydig Cell Tumor

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