“…1) Systemic disorders such as chronic renal failure [28][29][30][31][32], systemic lupus erythematosus [18,[33][34][35][36][37][38][39][40][41], rheumatoid arthritis [42,43], primary and secondary hyperparathyroidism [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32], alkaptonuria [44], diabetes mellitus [45,46], colitis ulcerous [47]. These diseases weaken the normal collagenous structures .…”