Bilateral Severe Genu Varum in Dyggve-Melchior-Clausen Syndrome – A Case Report

Abstract

Introduction: Dyggve-Melchior-Clausen (DMC) syndrome was described in 1962 as an autosomal recessive type of spondyloepimetaphyseal dysplasia associated with mental retardation. Dymeclin (DYM) gene on chromosome 18q12.1 that encodes for DYM protein which is expressed in cartilage, bone, and brain is mutated in DMC. Case Report: A 6 year -old male child presented with bilateral gradually progressive genu varum deformity of 4 years’ duration. There was no significant past medical and family history. A plain radiograph of his knee, pelvis, and spine shows some classical signs of skeletal dysplasia. A plain radiograph of the pelvis with both hips shows a classical semilunar, irregular lacy appearance around the iliac crest which is a pathognomonic radiological sign of this syndrome. Conclusion: The radiographic lacy appearance of iliac crests and generalized platyspondyly with double-humped end plates are pathognomonic of DMC. Keywords: Genu varum, Dyggve-Melchior-Clausen syndrome, spondyloepimetaphyseal dysplasia.

Total Hip Arthroplasty in Dyggve-Melchior-Clausen Syndrome: Literature Review and Case Report

“…The six-year-old male presented with bilateral, progressive genu varum over the course of 4 years. Radiographs revealed genu varum with platyspondyly of the dorsolumbar spine and semilunar lacy appearance around the iliac crest [ 2 ].…”

“…[ 1 ]. There is typically a good prognosis for general health and survival in the condition [ 2 ]. As of 2007, there were over 90 individuals with DMC or the variant Smith-McCort syndrome [ 3 ].…”