Bilateral Simultaneous Nonarteritic Anterior Ischaemic Optic Neuropathy: Case Report

Gündoğan, Fatih Ç.; Güven, Soner; Yolcu, Ümit; Sari, Sabahattin; Sobacı, Güngör

doi:10.3109/01658107.2013.817593

Cited by 8 publications

(3 citation statements)

References 23 publications

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“…In this case, several other illnesses that might potentially cause acute visual failure were considered. Nonarteritic ischemic optic neuropathy (NAION) is common in this age group and can cause abrupt visual loss and disc swelling, sometimes bilaterally [5][6][7]. However, our patient lacked systemic risk factors such as hypertension and hypercholesterolemia.…”

Section: Differential Diagnosesmentioning

confidence: 84%

Blinding Optic Neuropathy Associated With Carboplatin Therapy: A Case Report and Literature Review

Shihadeh,

Patrick,

Postma

et al. 2024

Cureus

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Various forms of cancer and chemotherapeutics are associated with optic neuropathy. Cisplatin is a platinum analogue chemotherapeutic commonly associated with ocular toxicity among many other serious adverse effects. Carboplatin is a more chemically stable platinum analogue that is generally better tolerated with a comparatively favorable side effect profile. There are very few reports of carboplatin precipitating optic neuropathy.This case report describes a rare occurrence of carboplatin-induced blinding optic neuropathy. We treated a patient receiving carboplatin for neuroendocrine bladder cancer who developed rapidly progressive bilateral optic neuropathy over the course of three days. Upon evaluation at our clinic, his visual acuity had declined to light perception only and 20/60 in his left and right eye, respectively. Carboplatin therapy was immediately held and steroids were initiated. Despite the intervention, the patient's visual deficits have not improved at the one-year follow-up.Although the mechanism by which carboplatin causes ocular toxicity remains speculative, arterial ischemia appears to be the likely mechanism given the irreversible nature of visual decline. As demonstrated by our patient's course, irreversible vision loss despite high-dose steroid intervention necessitates expeditious recognition and management of this rare adverse effect.

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Section: Differential Diagnosesmentioning

confidence: 84%

Blinding Optic Neuropathy Associated With Carboplatin Therapy: A Case Report and Literature Review

Shihadeh,

Patrick,

Postma

et al. 2024

Cureus

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“…15 NAION may be caused by diminished blood supply to structures such as the optic disc and the anterior optic nerve located by the posterior ciliary arteries. 16 Localized processes that increase optic pressure or cause edema may contribute to prolonged tissue hypoxia near the optic nerve along with systemic processes that decrease blood flow such as septicemia, hypovolemic shock, or severe adult respiratory distress syndrome. 17 Optic nerve damage and subsequent ION has also been noted to occur after surgical procedures such as coronary bypass surgery, bilateral neck dissection, and HD.…”

Section: Endophthalmitismentioning

confidence: 99%

Acute Bilateral Blindness in the Setting of Sudden Onset of Bilateral Proptosis and Ophthalmoplegia

Zarei

Sam

et al. 2021

Neur Clin Pract

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Purposeof review: Acute bilateral blindness has an extensive differential diagnosis that requires a careful history and physical exam to narrow down. In this paper we discuss the pathophysiology and radiographic findings of each possible diagnosis for acute bilateral blindness.Recent findings:Visual pathology with respect to bilateral blindness can be broadly broken down into three anatomic categories: media (i.e. the anterior and posterior chamber of the eye), retina, and neural visual pathway. Possible causes of rapid onset bilateral blindness include bilateral occipital infarcts, endogenous bacterial endophthalmitis, orbital cellulitis, orbital compartment syndrome, cavernous sinus thrombophlebitis, thyroid disease and bilateral non-arteritic ischemic optic neuropathy.Summary:In this case we present a patient with acute onset of bilateral blindness, in addition to bilateral ophthalmoplegia, proptosis, and orbital chemosis. We believe this rare case of acute bilateral blindness is thought provoking and aids in the understanding of the differential diagnosis and underlying pathophysiology of visual loss.

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“…NAION can affect either the left or the right eye, and in most cases, it only affects one eye. However, it is possible for both eyes to be affected in the same patient [11]. In the Ischemic Optic Neuropathy Decompression Trial (IONDT), it was observed that approximately 15% of patients experienced the development of NAION in their other eye within 5 years [12].…”

Section: Introductionmentioning

confidence: 99%

Intravitreal Aflibercept for Patients with Acute Nonarteritic Anterior Ischemic Optic Neuropathy: A Retrospective Trial

Cheng

Chiu

Chen

et al. 2023

JCM

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Purpose: This study aimed to investigate whether intravitreal aflibercept was safe and effective in patients with acute nonarteritic anterior ischemic optic neuropathy (NAION). Methods: This was a chart study of 25 individuals with acute NAION (25 eyes). An intravitreal injection of 2 mg/0.05 mL of aflibercept was administered to fifteen participants. The remaining ten patients in the control group were given standard care. The researchers measured the initial visual acuity, retinal nerve fiber layer thickness (RNFLT), and automated perimetry. During the follow-up period, the researchers measured the final visual acuity, RNFLT, automated perimetry, and side effects. Results: Visual acuity and visual field assessment were significantly improved in the study group, and optical coherence tomography testing demonstrated significant disc edema resolution. The therapy results differed significantly between the two groups regarding visual outcomes (F = 0.027, p = 0.039) and RNFLT decrease (F = 5.507, p = 0.003). However, the difference in visual field alterations was not significant (F = 0.724, p = 0.387). Conclusions: Intravitreal injection of aflibercept can significantly improve visual acuity and resolve disc edema in patients with acute NAION. Intravitreal aflibercept may be an alternative treatment for acute NAION. However, a large series investigation is needed to assess the long-term therapeutic benefit and safety of intravitreal aflibercept in patients with acute NAION.

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Bilateral Simultaneous Nonarteritic Anterior Ischaemic Optic Neuropathy: Case Report

Cited by 8 publications

References 23 publications

Blinding Optic Neuropathy Associated With Carboplatin Therapy: A Case Report and Literature Review

Blinding Optic Neuropathy Associated With Carboplatin Therapy: A Case Report and Literature Review

Acute Bilateral Blindness in the Setting of Sudden Onset of Bilateral Proptosis and Ophthalmoplegia

Intravitreal Aflibercept for Patients with Acute Nonarteritic Anterior Ischemic Optic Neuropathy: A Retrospective Trial

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