Bilateral Symmetrical Subepidermal Calcified Nodules of the Eyelids

Abstract

A subepidermal calcified nodule is an uncommon variant of calcinosis cutis and only a limited number of cases have been reported about the eyelid nodules in the literature. A 20-year-old male was referred to our department with symmetrical nodules on both upper eyelids enlarging over 3 years. Both nodules were removed by excisional biopsy. After the histopathologic evaluation, the diagnosis was subepidermal calcified nodule. He had a complete recovery with no recurrence and acceptable aesthetic appearance. As a rare entity, subepidermal calcified nodule should be thought in differential diagnosis of eyelid nodular lesions and symmetrical appearance may be seen.

A Firm, Verrucous, Hyperkeratotic Periorbital Papule on an Adult Man: Answer

“…Most SCN lesions are solitary, but multiple lesions have been reported, including bilateral symmetric periorbital lesions. 2,4 Most SCN (95%) are asymptomatic; however, rarely have been reported to be associated with pain/discomfort, pruritus, or swelling. 2 The lesions were typically present for 6-12 months before patients seeking care.…”

Subepidermal calcified nodule in upper eyelid: A case report and review of the literature

“…[ 9 12 13 ] Eyelid is a rare site of SCN. [ 11 ] To best our knowledge, only five reports of SCN on eyelid were reported in the literature; three of them in healthy adult females,[ 3 14 15 ] one in healthy adult male[ 16 ] and one in adult female with tumoral calcinosis. [ 17 ] Nico and Bergonse reported SCN on the eyelids of two healthy Brazilian female patients.…”

“…[ 15 ] A 20-year-old healthy male with symmetrical nodules on both upper eyelids enlarging over 3 years. [ 16 ] A Caucasian middle age female with multiple eyelid calcifications and biochemical features of tumoral calcinosis. [ 17 ]…”