Bilateral Synchronous Plasmacytoma of the Testis

Bilateral Testicular Plasmacytomas

“…Extramedullary plasmacytomas are rare and account for 3-5% of plasma cell neoplasms. [3] Occurrence within the testicle is even more rare and makeup <0.2% of all testicular tumors, although it has been estimated that upward of 2% of patients with multiple myeloma will be found to have testicular plasmacytomas at the time of autopsy. [1,3,6] More typically, solitary extramedullary plasmacytomas are seen in the head, neck, respiratory, gastrointestinal, and central nervous systems.…”

“…[3] Occurrence within the testicle is even more rare and makeup <0.2% of all testicular tumors, although it has been estimated that upward of 2% of patients with multiple myeloma will be found to have testicular plasmacytomas at the time of autopsy. [1,3,6] More typically, solitary extramedullary plasmacytomas are seen in the head, neck, respiratory, gastrointestinal, and central nervous systems. [3,7] While plasmacytomas within the testes in the setting of multiple myeloma are an uncommon but known entity, to have synchronous bilateral lesions is an extremely rare occurrence, with 5 such cases report in the literature.…”

“…[1,3,6] More typically, solitary extramedullary plasmacytomas are seen in the head, neck, respiratory, gastrointestinal, and central nervous systems. [3,7] While plasmacytomas within the testes in the setting of multiple myeloma are an uncommon but known entity, to have synchronous bilateral lesions is an extremely rare occurrence, with 5 such cases report in the literature. Synchronous cancer can be defined by the presentation of lesions simultaneously or those occurring within 6 months of one another.…”

“…[8,10,11] Several cases have been reported where these lesions presented in the absence of such history. [3,10] The patient we present here was above average for age and had previously undergone chemotherapy and autologous bone marrow transplantation for treatment of his known myeloma, so the discovery of his bilateral testicular plasmacytomas was thought to be most consistent with disease recurrence.…”

“…[1,2] At the time of diagnosis, the majority of testicular tumors are unilateral, with bilateral testicular tumors occurring only 1-2% of the time. [3] Bilateral testicular tumors can occur either metachronously (80-85%) or synchronously (15-20%). [4] We present sonographic features, with histopathologic correlation, in a 71-year-old man who presented with scrotal pain and was found to have bilateral testicular hypoechoic masses confirmed to be plasmacytomas.…”