Bilateral synchronous tibial periosteal osteosarcoma with familial incidence

Maheshwari, Aditya V.; Jelinek, James S.; Seibel, Nita L.; Meloni‐Ehrig, Aurelia; Kumar, Dhiren; Henshaw, Robert M.

doi:10.1007/s00256-012-1376-7

Cited by 10 publications

(5 citation statements)

References 25 publications

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“…Genetic factors may be a novel approach for further research in periosteal osteosarcoma. Maheshwari et al found the TP53 gene (exon 8) mutation in two PO patients [3]. In our patient, genetic analysis of the tumour showed a TP53 (exon 8) p.R280K point mutation, and CCNE1 gene copy number variants (CNVs).…”

Section: Discussionsupporting

confidence: 46%

Isolated diaphragmatic metastasis from periosteal osteosarcoma of the humerus: a case report

Zhao

Qin

et al. 2020

J Cardiothorac Surg

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Background: Isolated diaphragmatic metastasis is rarely associated with periosteal osteosarcoma. Case presentation: A 24-year-old female patient was found to have periosteal osteosarcoma of the right humerus 11 years ago. Computed tomography showed a mass in her left chest in 2018, and thoracotomy was performed to remove the tumour. The tumour showed the same characteristics as the original periosteal osteosarcoma. Genetic analysis of the tumour sample showed a TP53 point mutation and CCNE1 gene copy number variants. Conclusions: We believe this is the first case report of haematogenous metastasis to the diaphragm of periosteal osteosarcoma, and an investigation of the genetic factors may help to unravel the underlying cause of periosteal osteosarcoma.

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Section: Discussionsupporting

confidence: 46%

Isolated diaphragmatic metastasis from periosteal osteosarcoma of the humerus: a case report

Zhao

Qin

et al. 2020

J Cardiothorac Surg

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“…Skip metastasis usually emerges in the same bone, while those occurring in different bones are named transarticular skip metastasis. Synchronous multifocal lesions refer to more than one lesion at presentation without visceral metastasis[ 31 , 32 ]. Synchronous multifocal lesions have been reported in osteosarcoma, MFH, and chondrosarcoma[ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Malignant fibrous histiocytoma of the bone in a traumatic amputation stump: A case report and review of the literature

Zhao¹,

Yan²,

Yao³

et al. 2021

WJCC

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BACKGROUND Malignant fibrous histiocytoma (MFH) is one of the most common soft tissue sarcomas among adults. It is characterized by large size, high grade, and biological aggressiveness. There are many reports of MFH after local stimulation, such as bone fracture, implants, and chronic osteomyelitis. In this paper, we report a patient who developed MFH 6 years after amputation, suggesting that wound healing and mechanical force play a role in the local stimulation of this disease. CASE SUMMARY A 66-year-old man complained of persistent pain in his residual mid-thigh. He had undergone amputation surgery due to a traffic accident 6 years prior. Physical examination showed tenderness but no abnormalities in appearance. X-ray radiographs and magnetic resonance imaging supported the diagnosis of a tumor, and a biopsy confirmed that the lesion was MFH. The patient received neoadjuvant chemotherapy and left hip disarticulation. During the 6-mo follow-up, there were no symptoms of recurrence. CONCLUSION Postsurgery MFH has been reported before, and many studies have attributed it to the biological effects of implants. Our case report shows that this disease can develop without an implant and thus highlights the importance of local stimulation. The wound-healing process and mechanical force can both promote this tumor, but whether they directly cause MFH needs further investigation.

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“…There is wide consensus regarding aggressive resection being used for PO (1,17,18). Tumors have been reported to spread further than could be imaged using CT or MRI, and in addition, an incomplete tumor resection is considered as the most important risk factor for an adverse outcome.…”

Section: Discussionmentioning

confidence: 99%

Intentional marginal resection of periosteal osteosarcoma in combination with neoadjuvant chemotherapy: A report of two cases and a review of the literature

Chen

et al. 2017

Oncology Letters

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Abstract.A wide resection of the tumor with or without chemotherapy is the treatment of choice for periosteal osteosarcoma (PO) of the extremities, however, post-operative limb function and quality of life could be compromised. The present study reports two cases of 14-year-old boys who presented with progressively enlarging masses in their right knee regions. Computed tomography and magnetic resonance imaging scans indicated a fusiform space-occupying mass encircling the bone cortex, with stippled calcification. A diagnosis of PO was suspected. The histological findings confirmed the diagnosis of intermediate PO. Pre-operative chemotherapies were started, and good responses were detected by clinical evaluation and histological findings. Surgeries preserving the functional structures, including neurovascular bundles, tendons, muscles and epiphyses, were performed, followed by routine chemotherapy. The two patients experienced disease-free survival with follow-up times of 37 and 108 months, respectively. The patients were satisfied with the results of the treatment and they returned to normal life activities. These two cases indicated that a marginal resection of the tumor in conjunction with effective neoadjuvant chemotherapy may be an ideal alternative treatment for intermediate PO, since survival along with well-preserved limb function could be guaranteed. By contrast, a wide excision could result in the loss of limb function.

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Bilateral synchronous tibial periosteal osteosarcoma with familial incidence

Cited by 10 publications

References 25 publications

Isolated diaphragmatic metastasis from periosteal osteosarcoma of the humerus: a case report

Isolated diaphragmatic metastasis from periosteal osteosarcoma of the humerus: a case report

Malignant fibrous histiocytoma of the bone in a traumatic amputation stump: A case report and review of the literature

Intentional marginal resection of periosteal osteosarcoma in combination with neoadjuvant chemotherapy: A report of two cases and a review of the literature

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