Bilateral Testicular Biopsy in Men with Varicocele

Ibrahim, Ahmed; Awad, Hosni; El-Haggar, Sahar Mohamed; Mitawi, Bahgat A.

doi:10.1016/s0015-0282(16)42620-8

Cited by 54 publications

(27 citation statements)

References 14 publications

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“…Some authors have reported that varicocele repair can result in significant improvement in sperm parameters of azoospermic men with spermatogenic failure [7,12]. The clinical finding of this condition is that azoospermic men undergoing repetitive TESE þ ICSI procedures may have sperm in their ejaculate so that there is no need left for more invasive procedures [3].…”

Section: Discussionmentioning

confidence: 99%

“…The effect of varicocele on testis histology and the effects on semen parameters were investigated [7,8,18]. Varicocelectomy has demonstrable benefits for nonobstructive azoospermic patients with spermatogenic failure [7].…”

Section: Is Varicocele a Prognostic Factor For Determining Sperm Retrmentioning

confidence: 99%

“…Varicocelectomy has demonstrable benefits for nonobstructive azoospermic patients with spermatogenic failure [7]. The most common change in the varicocele bearing-testis was the maturation arrest at the spermatid stage [7]. The pathological findings in testis were endothelial proliferation and Leydig cell hyperplasia [7][8][9].…”

Section: Is Varicocele a Prognostic Factor For Determining Sperm Retrmentioning

confidence: 99%

“…The most common change in the varicocele bearing-testis was the maturation arrest at the spermatid stage [7]. The pathological findings in testis were endothelial proliferation and Leydig cell hyperplasia [7][8][9]. Another important observation was the worsening of pathological changes with the increasing duration of the varicocele [9].…”

Section: Is Varicocele a Prognostic Factor For Determining Sperm Retrmentioning

confidence: 99%

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Is Varicocele a Prognostic Factor for Determining Sperm Retrieval Rate Before Testicular Sperm Extraction?

Tunç

Gürocak

Sözen

et al. 2005

Archives of Andrology

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&66 nonobstructive azoospermic men with normal genetic analysis composed of 32 (48%) patients with and 34 (52%) patients without varicocele were evaluated for the rate of sperm extraction five months after the varicocelectomy. Sperm retrieval was successful in 22 of 32 patients (68%) who had been operated because of varicocele and in 13 of 34 patients (38.2%) who had no varicocele (OR ¼ 3.55) (CI: 1.15-11.27) (p ¼ 0.025). Overall, sperm extraction was successful in 35 of 66 patients (53%). Repair of varicocele in non-obstructive azoospermic patients may return spermatogenesis to normal in spermatogenetic focuses. So, the presence of varicocele and its treatment might be considered as a prognostic factor for sperm retrieval in these patients.

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Section: Discussionmentioning

confidence: 99%

Section: Is Varicocele a Prognostic Factor For Determining Sperm Retrmentioning

confidence: 99%

Section: Is Varicocele a Prognostic Factor For Determining Sperm Retrmentioning

confidence: 99%

Section: Is Varicocele a Prognostic Factor For Determining Sperm Retrmentioning

confidence: 99%

See 2 more Smart Citations

Is Varicocele a Prognostic Factor for Determining Sperm Retrieval Rate Before Testicular Sperm Extraction?

Tunç

Gürocak

Sözen

et al. 2005

Archives of Andrology

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“…A number of studies have attempted to characterize the changes in testicular histology associated with varicocele (23)(24)(25)(26)(27). Most of these studies documented the bilateral nature of these changes.…”

Section: Testicular Histology and Biochemical Functionmentioning

confidence: 99%

Varicocele: Evaluation and treatment

Zini¹

2002

J Sex Reprod Med

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Varicocele is the most common identifiable pathology in infertile men. It is present in 15% of the male population, in approximately 35% of men with primary infertility and in 50% to 80% of men with secondary infertility. It is generally accepted that varicocele exerts a negative influence on spermatogenesis and steroidogenesis, primarily by elevating testicular temperature. However, the effect of varicocelectomy on the restoration of testicular function and fertility in adults is the subject of ongoing controversy. Microsurgical varicocelectomy has been advocated as the 'gold standard' method, based on the low complication rate associated with this procedure. In the era of advanced assisted reproduction, varicocelectomy is a valuable tool in the management of infertile men. Key Words: Assisted reproduction; Male infertility; Spermatogenesis; Varicocele; VaricocelectomyVaricocèle : Évaluation et traitement RÉSUMÉ : La varicocèle est la pathologie identifiable la plus répandue chez les hommes infertiles. Elle s'observe chez 15 % de la population masculine, chez environ 35 % des hommes ayant un problème d'infertilité primaire et chez 50 à 80 % des hommes ayant une infertilité secondaire. On s'entend en général pour dire que la varicocèle exerce une influence négative sur la spermatogenèse et sur la stéroïdogenèse, principalement par le biais d'une élévation de la température des testicules. Par contre, l'effet de l'ablation de la varicocèle sur le rétablissement de la fonction testiculaire et de la fertilité chez les adultes fait toujours l'objet d'une controverse. L'ablation de la varicocèle par microchirurgie a été proposée comme méthode standard sur la base du faible taux de complications qui lui est associé. À l'ère des technologies de reproduction de pointe, l'ablation de la varicocèle est un outil utile pour le traitement des hommes infertiles. V aricocele is defined as dilated testicular veins in the scrotum, and is the most common identifiable pathology in infertile men. Although it is accepted that varicocele exerts a negative influence on male fertility potential, the effect of varicocelectomy on the restoration of fertility in men is the subject of ongoing controversy. The present article is not intended to resolve controversial issues regarding varicocele, but rather should provide the reader with a basic overview of the subject, with emphasis on the pathophysiology, diagnosis and treatment of this condition. INCIDENCEThe incidence of varicocele in the general male population is approximately 15% (1-4). The incidence in men presenting for infertility is about 35%, and in men with secondary infertility it is 50% to 80% (5-7). Although varicocele is almost always larger and more common on the left side (5,8), the incidence of bilateral varicocele is approximately 50%. The rare, isolated, right-sided varicocele generally suggests that the right internal spermatic vein enters the right renal vein, but it should prompt further investigation because this finding may be associated with situs inversus or retro...

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Varicocele

Saypol

1981

Journal of Andrology

171

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Bilateral Testicular Biopsy in Men with Varicocele

Cited by 54 publications

References 14 publications

Is Varicocele a Prognostic Factor for Determining Sperm Retrieval Rate Before Testicular Sperm Extraction?

Is Varicocele a Prognostic Factor for Determining Sperm Retrieval Rate Before Testicular Sperm Extraction?

Varicocele: Evaluation and treatment

Varicocele

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