Bilateral thalamic involvement in dengue infection

Kamble, Ravindra B; Peruvamba, Jayakumar; Kovoor, J.M.E.; Ravishankar, S.; Kolar, Balasubramanya

doi:10.4103/0028-3886.37103

Cited by 31 publications

(17 citation statements)

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“…The MRI findings noted in our case are most characteristic of JE and not commonly seen with dengue fever. [10] The pattern of involvement. [bilateral thalamic involvement with foci of hemorrhage, with involvement of temporal lobe and brain stem] is very uncommon with dengue.…”

Section: Discussionmentioning

confidence: 99%

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Dengue encephalitis

Borawake¹,

Wagh²,

Dole³

2011

Indian Journal of Critical Care Medicine

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We report a case of dengue fever with features of encephalitis. The diagnosis of dengue was confirmed by the serum antibodies to dengue and the presence of a dengue antigen in the cerebrospinal fluid. This patient had characteristic magnetic resonance imaging brain findings, mainly involving the bilateral thalami, with hemorrhage. Dengue is not primarily a neurotropic virus and encephalopathy is a common finding in Dengue. Hence various other etiological possibilities were considered before concluding this as a case of Dengue encephalitis. This case explains the importance of considering the diagnosis of dengue encephalitis in appropriate situations.

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Section: Discussionmentioning

confidence: 99%

“…There is only one similar case report by Kamble et al ., with similar MRI findings. [10] This case is presented to highlight the possible extensive involvement of the brain by dengue virus.…”

Section: Discussionmentioning

confidence: 99%

Dengue encephalitis

Borawake¹,

Wagh²,

Dole³

2011

Indian Journal of Critical Care Medicine

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“…[23456] The CNS manifestations can be attributed to three factors (a) neurotropic effect, (b) secondary to systemic manifestation, and (c) postinfectious sequelae including immune-mediated reactions. [67] Findings of magnetic resonance imaging (MRI) of the brain have been reported in several case reports and studies,[2891011121314] with a variable spectrum of findings.…”

Section: Introductionmentioning

confidence: 99%

MRI features in dengue encephalitis: A case series in South Indian tertiary care hospital

Soni

Das

George

et al. 2017

Indian Journal of Radiology and Imaging

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Dengue virus, a RNA virus of family Flaviviradae is considered non-neurotropic. Increasing studies and case reports reveal neurological manifestations of dengue virus. In our case series, we have evaluated magnetic resonance imaging (MRI) findings of 3 patients with dengue fever diagnosed by positive dengue NS1 antigen with neurological symptoms, which revealed nonspecific imaging features of dengue encephalitis in two cases and dengue meningoencephalitis in one case. Autopsy findings are also correlated in 2 patients who succumbed to their disease. This case series underlines the consideration of dengue encephalitis in patients of dengue fever with neurological symptoms and relevant imaging findings.

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“…Encephalitis features in brain (Hyperintense areas) can be seen in global pallidus, temporal lobes [20,21], thalamus [22], hippocampus [23], pons, and spinal cord [24]. In our study, MRI Brain study showed Bilateral hyperintense areas in temporal lobes in 9 patients, thalamus in 3 patients, pons in 1 patient, and remaining patients had normal MRI findings (MRI Brain was not done in non encephalitis patients).…”

Section: Discussionmentioning

confidence: 47%

Dengue encephalitis – clinical spectrum and outcome

Rao¹,

Pradeep²,

Dnyaneshwar³

et al. 2013

Intern Med Inside

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Background: Dengue viral infection is common worldwide caused by dengue virus. Recent studies have shown dengue viral infection causing encephalitis with high morbidity and mortality. The Dengue encephalitis patients usually present with altered sensorium, elevated lab parameters and high antibody titres at the time of admission. Aims: To compare initial lab parameters, clinical spectrum and outcome in patients of dengue fever with or without encephalitis. Settings and design:The study was done in a multi-speciality teaching hospital. Fourty nine patients were included in the study with febrile illness and thrombocytopenia, proved to be having Dengue fever. Material and Methods: A prospective study was conducted on 49 patients with febrile illness and thrombocytopenia proved to be having Dengue fever during a period of 6 months were included. Initial lab parameters, clinical spectrum and outcome were compared in patients with or without encephalitis. Statistical analysis used:The database of all parameters were analysed using "STATA SOFTWARE VERSION10.0". Results: 49 cases of proven dengue fever were included in the study. Among these patients 25 patients had no encephalitis and 24 patients had encephalitis. Most common clinical features in patients without encephalitis were fever with chills and rigors and in patients with encephalitis were fever with altered sensorium (P-value < 0.05). Among total 49 patients, 24 patients had encephalitis. There were no statistical difference among factors like age, sex, PCV, Platelet count, PT, and INR in these two groups (with or without encephalitis) at admission. The APTT, serum Ig-M antibodies, Ig-G antibodies, SGOT and SGPT were significantly high in encephalitis group (P-value < 0.05). All 25 dengue patients without encephalitis recovered completely without any complication. Among 24 dengue patients with encephalitis, 22 patients recovered completely (independent for activities of daily living), and 2 patients died (due to severe sepsis with MODS). Conclusions: Increased incidence of dengue fever with encephalitis in the recent years, in the absence of single sensitive test for detecting dengue encephalitis, variable CSF and MRI Brain features, and associated high morbidity and mortality, this study may be helpful in focussing on early diagnosis and aggressive initial management which can influence final outcome.

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Bilateral thalamic involvement in dengue infection

Cited by 31 publications

References 0 publications

Dengue encephalitis

Dengue encephalitis

MRI features in dengue encephalitis: A case series in South Indian tertiary care hospital

Dengue encephalitis – clinical spectrum and outcome

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