Bilateral ventricular myocardial dysplasia in a Shar-Pei dog

Ocarino, Natália de Melo; Nascimento, Evaldo; Paniago, Juliana Del Giúdice; Serákides, Rogéria

doi:10.1590/s0102-09352011000300034

Cited by 1 publication

(1 citation statement)

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“…Unlike animals that develop obesity, we showed that OR animals submitted to the HFD presented cardiac morphological changes with lower values of total heart and LV sizes, and their respective relationships with the tibia length. These findings could indicate a possible prevention of cardiac hypertrophy ( 23 ), since cardiomyocytes CSA was similar to the C group. Furthermore, the lower deposition of collagen observed in the OR group could justify the lower weight of the cardiac chambers ( 24 ).…”

Section: Discussionsupporting

confidence: 53%

Isolated obesity resistance condition or associated with aerobic exercise training does not promote cardiac impairment

Cordeiro

Silva

Campos

et al. 2021

Braz J Med Biol Res

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Mechanisms involved in cardiac function and calcium (Ca 2+ ) handling in obese-resistant (OR) rats are still poorly determined. We tested the hypothesis that unsaturated high-fat diet (HFD) promotes myocardial dysfunction in OR rats, which it is related to Ca 2+ handling. In addition, we questioned whether exercise training (ET) becomes a therapeutic strategy. Male Wistar rats (n=80) were randomized to standard or HFD diets for 20 weeks. The rats were redistributed for the absence or presence of ET and OR: control (C; n=12), control + ET (CET; n=14), obese-resistant (OR; n=9), and obese-resistant + ET (ORET; n=10). Trained rats were subjected to aerobic training protocol with progressive intensity (55-70% of the maximum running speed) and duration (15 to 60 min/day) for 12 weeks. Nutritional, metabolic, and cardiovascular parameters were determined. Cardiac function and Ca 2+ handling tests were performed in isolated left ventricle (LV) papillary muscle. OR rats showed cardiac atrophy with reduced collagen levels, but there was myocardial dysfunction. ET was efficient in improving most parameters of body composition. However, the mechanical properties and Ca 2+ handling from isolated papillary muscle were similar among groups. Aerobic ET does not promote morphological and cardiac functional adaptation under the condition of OR.

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Section: Discussionsupporting

confidence: 53%