Bilateral versus single lung transplantation for idiopathic pulmonary fibrosis

Lehmann, Sven; Leontyev, Sergey; Garbade, Jens; Barten, M.; Samson, Patrick von; Meyer, Antonia; Strüber, Martin; Mohr, FW

doi:10.1055/s-0032-1332408

Cited by 8 publications

(12 citation statements)

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“…Accordingly many studies have not observed superior survival for DLT over SLT for IPF recipients. [3][4][5] Chauhan and colleagues 8 demonstrated equivalent survival between SLT and DLT for concurrently listed IPF recipients from 2001 to 2009, suggesting that the increased use of SLT for IPF patients may increase availability of organs for other candidates without compromising recipient outcomes. Also some clinicians advocate for sequential SLT as an alternative to DLT, arguing that many patients may not require the second transplant and citing the significant perioperative morbidity associated with the DLT procedure itself.…”

Section: Commentmentioning

confidence: 99%

“…However controversy regarding the ideal procedure for IPF lung transplant recipients is based on conflicting reports regarding whether double lung transplant (DLT) offers a survival advantage over single lung transplant (SLT). [1][2][3][4][5][6][7][8][9] Most recently a report suggested that DLT should be the "procedure of choice" for pulmonary fibrosis patients younger than 70 years of age, especially in patients with high lung allocation scores (LAS). 9 However a significant number of IPF recipients treated with SLT remain, indicating that the lung transplant community still collectively believes SLT is an appropriate or the only option for some proportion of IPF recipients.…”

mentioning

confidence: 99%

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Single and Double Lung Transplantation Have Equivalent Survival for Idiopathic Pulmonary Fibrosis

Ranganath

Malas

Phillips

et al. 2020

The Annals of Thoracic Surgery

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Section: Commentmentioning

confidence: 99%

mentioning

confidence: 99%

Single and Double Lung Transplantation Have Equivalent Survival for Idiopathic Pulmonary Fibrosis

Ranganath

Malas

Phillips

et al. 2020

The Annals of Thoracic Surgery

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“…Early studies showed a clear survival benefit in SSLTx. , while others have disputed this or could not find a significant difference between the two types . Other studies are ambiguous like the study of Whelan et al .…”

Section: Discussionmentioning

confidence: 95%

“…Early studies showed a clear survival benefit in SSLTx. [12,41,42], while others have disputed this or could not find a significant difference between the two types [1,9,17,43,44]. Other studies are ambiguous like the study of Whelan et al [45] with data of the ISHLT, who found that, in patients with IPF and pulmonary hypertension, SSLTx carried a greater risk for early mortality, while rising postoperative pulmonary pressures in SLTx patients were also associated with increased mortality.…”

Section: Sltx Versus Ssltxmentioning

confidence: 99%

Determinants of survival in lung transplantation patients with idiopathic pulmonary fibrosis: a retrospective cohort study

et al. 2018

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Summary Survival after lung transplantation (LTx) for idiopathic pulmonary fibrosis (IPF) is worse compared to other indications for LTx. We investigated the effect of several pretransplant variables including the use of pretransplant corticosteroids (CS) on post‐transplant graft and chronic lung allograft dysfunction (CLAD)‐free survival and functional testing (maximum inspiratory and expiratory pressure, six‐minute walk test, quadriceps and hand pinch force) in a small cohort of IPF patients. We retrospectively compared two groups of IPF patients (n = 36 on CS vs. n = 18 not on CS) who underwent LTx between 2000 and 2016. Analysis of 54 IPF‐LTx patients showed no significant effect on graft survival or functional tests except for maximum inspiratory pressure (P = 0.033) between these two groups (all LTx patients, CS vs. no CS). Regression analysis showed significant impact of procedure with a hazard ratio of 0.423 (CI 95% 0.194, 0.924) favoring sequential single LTx (SSLTx) compared to single lung transplantation (SLTx). When analyzing only the 40 SSLTx patients, corticosteroid‐free patients showed significantly better graft survival compared to patients on CS (P = 0.045) and CLAD‐free survival (P = 0.019). The possible detrimental effect of corticosteroid therapy before LTx was demonstrated in this cohort of SSLTx patients, which questions the use of corticosteroids in a pretransplantation setting.

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“…To date, no randomized controlled studies have weighed the superiority of SLT to BLT in patients with IPF. We compared the data collected at our centre with those published in other countries 10,11,[15][16][17][18][19][20][21][22] (Table 4). Weiss ES and his colleagues reviewed 1256 patients with pulmonary fibrosis and identified that BLT was associated with a lower risk of mortality at 1 year for those with highest LAS.…”

Section: Discussionmentioning

confidence: 99%

Single versus bilateral lung transplantation for idiopathic pulmonary fibrosis

Dong

Gao

et al. 2019

Clinical Respiratory J

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Background Lung transplantation, either single or bilateral, serves as the only effective treatment for end‐stage idiopathic pulmonary fibrosis (IPF), but their superiority is still being debated, and its application in Chinese patients has not been data analysed. Methods We reviewed 109 IPF patients who received lung transplantation at our centre between January 1, 2015 and December 31, 2017. The patients were divided into single lung transplantation (SLT) group and bilateral lung transplantation (BLT) group. We compared the two groups’ demographic characteristics and clinical indexes (intraoperative conditions, postoperative complications, follow‐ups and life qualities). Results Patients in BLT group were significantly younger than those in SLT group (P < 0.001), and had more pretransplant infections (P = 0.007). The total ischemic time (P < 0.001) was shorter and intraoperative blood loss was less (P = 0.001) in SLT group. No significant difference was found in the proportion of patients in using anti‐fibrosis drugs, pulmonary artery pressure, extracorporeal membrane oxygenation during the surgery; the length of intensive care unit stay; the incidence of complication; and the overall survival rate between two groups. However, the hierarchical analysis found that patients aged > 60 years showed a better survival in SLT group (P = 0.008). Both groups got normal MOS 36‐item Short Form (SF‐36) scores, and the scores of BLT were higher than those of SLT. The BLT group had better lung function than SLT group 1 year post‐lung transplantation. Conclusions Both SLT and BLT are effective and SLT is more favourable for the patients of > 60 years.

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Bilateral versus single lung transplantation for idiopathic pulmonary fibrosis

Cited by 8 publications

References 0 publications

Single and Double Lung Transplantation Have Equivalent Survival for Idiopathic Pulmonary Fibrosis

Single and Double Lung Transplantation Have Equivalent Survival for Idiopathic Pulmonary Fibrosis

Determinants of survival in lung transplantation patients with idiopathic pulmonary fibrosis: a retrospective cohort study

Single versus bilateral lung transplantation for idiopathic pulmonary fibrosis

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