Bilateral Wilms tumors (WT) treated with the SIOP 93 protocol in France: Epidemiological survey and patient outcome

Sudour, H.; Audry, G; Schleimacher, Gudrun; Patte, Catherine; Dussart, Sophie; Bergeron, Christophe

doi:10.1002/pbc.24059

Cited by 48 publications

(66 citation statements)

References 24 publications

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“…This equals recent data published by NWTS4 and NWTS5 with 82.1 % OS after 10 years [ 17 ] , by the French group with 89.5 ± 6.5 % after 5 years [ 18 ] and by the Italian group with 80 ± 5 % OS after 4 years [ 9 ] . And it is signifi cantly superior to the survival rates of 69 % reported earlier by the UKCCSG's study [ 11 ] and of 64 % by the SIOP [ 5 ] .…”

Section: Patients With a Localized Disease Without Pretreatment And supporting

confidence: 89%

Pretreatment for Bilateral Nephroblastomatosis is an Independent Risk Factor for Progressive Disease in Patients with Stage V Nephroblastoma

et al. 2014

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Section: Patients With a Localized Disease Without Pretreatment And supporting

confidence: 89%

Pretreatment for Bilateral Nephroblastomatosis is an Independent Risk Factor for Progressive Disease in Patients with Stage V Nephroblastoma

et al. 2014

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“…In the SIOP−2001 study, patients with bilateral disease received preoperative chemotherapy including vincristine and actinomycin D until NSS was deemed feasible, with response evaluations performed every 4 weeks. However, several studies have shown that prolonged preoperative chemotherapy is often ineffective (especially as many bilateral tumours are the chemotherapy-insensitive stromal subtype) and could even result in an increased risk of the presence of anaplasia, disease progression, and development of metastases 31,32,34 . Thus, the UMBRELLA protocol limits preoperative chemotherapy to a maximum of 12 weeks, with time intervals for evaluation fixed to 6 weeks, to be comparable with the COG approach for future studies.…”

Section: Cmn Rccmentioning

confidence: 99%

Rationale for the treatment of Wilms tumour in the UMBRELLA SIOP–RTSG 2016 protocol

et al. 2017

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“…11, 12, 34, 35 An overriding goal was to improve EFS balanced with conservation of renal tissue. Our goal was to have at least 50% of patients undergo bilateral nephron-sparing surgery (NSS).…”

Section: Discussionmentioning

confidence: 99%

Results of the First Prospective Multi-institutional Treatment Study in Children With Bilateral Wilms Tumor (AREN0534)

et al. 2017

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Objective The Children's Oncology Group (COG) study AREN0534 aimed to improve EFS and OS while preserving renal tissue by intensifying pre-operative chemotherapy, completing definitive surgery by 12 weeks from diagnosis, and modifying post-operative chemotherapy based on histologic response. Summary Background Data No prospective therapeutic clinic trials in children with bilateral Wilms tumors (BWT) exist. Historical outcomes for this group were poor and often involved prolonged chemotherapy; on NWTS-5, 4-year event-free-survival (EFS) for all children with bilateral Wilms tumor was 56%. Methods Patients were enrolled and imaging studies were centrally reviewed to assess for bilateral renal lesions. They were treated with 3-drug induction chemotherapy (vincristine, dactinomycin and doxorubicin) for 6 or 12 weeks based on radiographic response followed by surgery and further chemotherapy determined by histology. Radiation therapy was provided for post-chemotherapy stage III and IV disease. Results 189/208 patients were evaluable. 4-year EFS and OS were 82.1% (95% CI: 73.5%-90.8%) and 94.9% (95% CI: 90.1%-99.7%. 23 patients relapsed and 7 had disease progression. After induction chemotherapy 163/189 (84.0%) underwent definitive surgical treatment in at least one kidney by 12 weeks and 39% retained parts of both kidneys. Surgical approaches included: unilateral total nephrectomy with contralateral partial nephrectomy (48%), bilateral partial nephrectomy (35%), unilateral total nephrectomy (10.5%), unilateral partial nephrectomy (4%) and bilateral total nephrectomies (2.5%). Conclusions This treatment approach including standardized three-drug preoperative chemotherapy, surgical resection within 12 weeks of diagnosis and response and histology-based post-operative therapy improved EFS and OS and preservation of renal parenchyma compared to historical outcomes for children with BWT.

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Bilateral Wilms tumors (WT) treated with the SIOP 93 protocol in France: Epidemiological survey and patient outcome

Cited by 48 publications

References 24 publications

Pretreatment for Bilateral Nephroblastomatosis is an Independent Risk Factor for Progressive Disease in Patients with Stage V Nephroblastoma

Pretreatment for Bilateral Nephroblastomatosis is an Independent Risk Factor for Progressive Disease in Patients with Stage V Nephroblastoma

Rationale for the treatment of Wilms tumour in the UMBRELLA SIOP–RTSG 2016 protocol

Results of the First Prospective Multi-institutional Treatment Study in Children With Bilateral Wilms Tumor (AREN0534)

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