Bilayer dressing based on aerogel/electrospun mats with self-catalytic hydrogen sulfide generation and enhanced antioxidant ability

Abstract

Hydrogen sulfide(H2S) releasing wound dressing has attracted much attention for its ability to promote cell proliferation, stimulate angiogenesis, and resist inflammation. Mimicking the skin structure, bilayer wound dressing based on...

A multifunctional chitosan based porous membrane for pH-responsive antibacterial activity and promotion of infected wound healing

“…3 The openness of the wound makes it easier to be invaded by pathogenic bacteria and eventually causes a wound infection, especially Staphylococcus aureus (S. aureus), which account for nearly 60% of all bacterial infections. [4][5][6] Bacterial infections can make the wounds difficult to heal and lead to a series of complications, such as accelerated metabolism and immune system dysfunction, resulting in expensive medical treatment and life-threatening injuries. 7 Thus, effective management of bacterial infected wounds has become a hot topic in cutaneous wound healing.…”

Endothelium-Mimicking Bilayer Vascular Grafts with Dual-Releasing of NO/H2S for Anti-Inflammation and Anticalcification

“…Chen et al constructed vascular grafts loaded with enzymes (Apyrase and 5′-nucleotide enzyme) using hyaluronic acid as the substrate to improve antiplatelet ability and endothelialization . Keratin contains cell-binding motifs of RGD and LDV, which beneficial to the adhesion and migration of cells. , The structure of keratin extracted by reduction contains thiols, carboxyl, and amino acids, which facilitate the combination of keratin with functional chemical small molecules. − In previous works, we have prepared a series of small-caliber vascular tissue engineering grafts based on the excellent biological properties of keratin to achieve long-term patency and rapid endothelialization in vivo implantation. , …”