Bilayer Tablet Formulation of Metformin HCl and Acarbose: A Novel Approach To Control Diabetes

Abstract

The goal of diabetes therapy today is to achieve and maintain as near normal glycemia as possible to prevent the long-term microvascular and macrovascular complications of elevated blood glucose levels. Oral therapeutic options for the treatment of type 2 diabetes mellitus, until recently, have been severely limited. Metformin, a biguanide, targets additional mechanisms of hyperglycemia by inhibiting hepatic glucose production and enhancing peripheral glucose uptake and thereby reducing insulin resistance; acarbose reversibly bind to pancreatic alpha-amylase and membrane-bound intestinal alpha-glucoside hydrolases. These enzymes inhibit hydrolysis of complex starches to oligosaccharides in the lumen of the small intestine and hydrolysis of oligosaccharides, trisaccharides, and disaccharides to glucose and other monosaccharides in the brush border of the small intestine. The two agents were found to have a remarkable effect on glycemic control. In the present investigation a bilayer tablet was prepared in which one layer gives instant action against diabetes and another layer maintain concentration of drug in plasma for longer periods.

DoE-Based Design of a Simple but Efficient Preparation Method for a Non-Effervescent Gastro-Retentive Floating Tablet Containing Metformin HCl

“…The matrix erosion was calculated at each time point as a percentage using Equation (4). SDs of Met HCl were prepared by co-spray-drying Met HCl with the excipients sodium alginate, PVP K-30, PEG6000, polyvinyl alcohol (PVA), HPMC K15M, and cetyl alcohol [43,[57][58][59]. Excipient screening was conducted to select an excipient that was suitable for floating and direct compression.…”

Formulation and evaluation of gastro-retentive floating bilayer tablet for the treatment of hypertension

“…Hardness: It was measured using Monsanto hardness tester. Thickness: A Mitutoyo Digital Vernier calliper stood adopted to regulate the thickness of ten arbitrarily designated tablets [18].…”

Formulation Development of Mucoadhesive Tablets for Treatment of Hypertension using Losartan Potassium

“…9 When it comes to protein and peptide administration or the systemic transport of tiny compounds that undergo first-pass metabolism, the buccal route is of particular importance. [10][11][12][13][14]…”