Bilberry (Vaccinium myrtillus L.) Powder Has Anticarcinogenic Effects on Oral Carcinoma In Vitro and In Vivo

Mauramo, Matti; Onali, Tuulia; Wahbi, Wafa; Vasara, Jenni; Lampinen, Anniina; Mauramo, Elina; Kivimäki, Anne; Martens, Stefan; Häggman, Hely; Sutinen, Meeri; Salo, Tuula

doi:10.3390/antiox10081319

Cited by 9 publications

(8 citation statements)

References 71 publications

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“…The powder obtained from the whole bilberry suppressed the proliferation, viability, invasion, and migration of oral squamous carcinoma cell lines in the zebrafish model [ 80 ]. The fruit extract also prohibited early preneoplastic liver cell lesions in rats [ 38 , 81 ].…”

Section: Blueberry/bilberry ( V Myrtillus / ...mentioning

confidence: 99%

Vaccinium Species (Ericaceae): Phytochemistry and Biological Properties of Medicinal Plants

et al. 2023

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The Vaccinium L. (Ericaceae) genus consists of a globally widespread and diverse genus of around 4250 species, of which the most valuable is the Vaccinioidae subfamily. The current review focuses on the distribution, history, bioactive compounds, and health-related effects of three species: cranberry, blueberry, and huckleberry. Several studies highlight that the consumption of Vaccinium spp. presents numerous beneficial health-related outcomes, including antioxidant, antimicrobial, anti-inflammatory, and protective effects against diabetes, obesity, cancer, neurodegenerative diseases and cardiovascular disorders. These plants’ prevalence and commercial value have enhanced in the past several years; thus, the generated by-products have also increased. Consequently, the identified phenolic compounds found in the discarded leaves of these plants are also presented, and their impact on health and economic value is discussed. The main bioactive compounds identified in this genus belong to anthocyanins (cyanidin, malvidin, and delphinidin), flavonoids (quercetin, isoquercetin, and astragalin), phenolic acids (gallic, p-Coumaric, cinnamic, syringic, ferulic, and caffeic acids), and iridoids.

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Section: Blueberry/bilberry ( V Myrtillus / ...mentioning

confidence: 99%

Vaccinium Species (Ericaceae): Phytochemistry and Biological Properties of Medicinal Plants

et al. 2023

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“…The inhibitory activity of the tested powder intensified with rising concentrations and was more pronounced in cancer cells when compared to normal cells. When compared with cetuximab, bilberry powder exhibited comparable or even more potent activity in a dose-dependent manner [120].…”

Section: Oncologymentioning

confidence: 99%

Vaccinium uliginosum and Vaccinium myrtillus—Two Species—One Used as a Functional Food

Kopystecka,

Kozioł,

Radomska

et al. 2023

Nutrients

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Vaccinium uliginosum L. (commonly known as bog bilberry) and Vaccinium myrtillus L. (commonly known as bilberry) are species of the genus Vaccinium (family Ericaceae). The red–purple–blue coloration of blueberries is attributed largely to the anthocyanins found in bilberries. Anthocyanins, known for their potent biological activity as antioxidants, have a significant involvement in the prophylaxis of cancer or other diseases, including those of metabolic origin. Bilberry is the most important economically wild berry in Northern Europe, and it is also extensively used in juice and food production. A review of the latest literature was performed to assess the composition and biological activity of V. uliginosum and V. myrtillus. Clinical studies confirm the benefits of V. uliginosum and V. myrtillus supplementation as part of a healthy diet. Because of their antioxidant, anti-inflammatory, anti-cancer, and apoptosis-reducing activity, both bog bilberries and bilberries can be used interchangeably as a dietary supplement with anti-free radical actions in the prevention of cancer diseases and cataracts, or as a component of sunscreen preparations.

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“…The bilberry fruit extract also inhibited early preneoplastic liver cell lesions in rats ( Hara et al, 2014 ). Whole bilberry powder inhibited the viability, proliferation, migration and invasion of oral squamous carcinoma cell lines in zebrafish model ( Mauramo et al, 2021 ).…”

Section: Uses Of Vaccinium Myrtillus Lmentioning

confidence: 99%

Bilberries: Curative and Miraculous – A Review on Bioactive Constituents and Clinical Research

Vaneková

Rollinger

2022

Front. Pharmacol.

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Bilberry (Vaccinium myrtillus L.) fruits are an important part of local diets in many countries and are used as a medicinal herb to treat various disorders. Extracts from fruits are often a part of eye health-promoting supplements, whereas extracts from leaves are advertised for type 2 diabetes mellitus and glycemic control. This review provides an overview of the current knowledge of the phytochemical contents of bilberry fruits and leaves and their bioactivities, critically summarizes origins of the health claims and the outcome of clinical trials, with special attention towards those published in the past 10 years. Overall, the three most referenced indications, which are type 2 diabetes mellitus, vision disorders and circulatory diseases, all include contradictory results with no clear conclusion as to the benefits and recommended dosages. Moreover, the indications for vision disorders and diabetes originate from unproven or false claims that have been repeated in research since the 20th century without consistent fact-checking. Beneficial clinical results have been attested for the treatment of dyslipidemia and chronic inflammatory disorders when applied as dietary supplementation of fresh bilberries or as anthocyanin-rich bilberry fruit extracts. However, there is a general lack of double-blinded controlled research with larger sample sizes.

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Bilberry (Vaccinium myrtillus L.) Powder Has Anticarcinogenic Effects on Oral Carcinoma In Vitro and In Vivo

Cited by 9 publications

References 71 publications

Vaccinium Species (Ericaceae): Phytochemistry and Biological Properties of Medicinal Plants

Vaccinium Species (Ericaceae): Phytochemistry and Biological Properties of Medicinal Plants

Vaccinium uliginosum and Vaccinium myrtillus—Two Species—One Used as a Functional Food

Bilberries: Curative and Miraculous – A Review on Bioactive Constituents and Clinical Research

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