Bildgebende Verfahren in der Dermatologie

Gammal, S. El; Gammal, Claudia El; Szliska, Christiane; Burgdorff, Tatjana; Landthaler, Míchael; Stolz, Wilhelm

doi:10.1007/978-3-7091-0577-1_13

Cited by 3 publications

(9 citation statements)

References 11 publications

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“…The upper echo-rich line corresponds to the 'impedance jump' between water and stratum corneum, as El Gammal et al [42] demonstrated by filling the 'valleys' between the dermatoglyphics with small amounts of fine copper powder. The upper echolucent layer represents the stratum corneum [42], which is about 100 Ìm thick in the fingertip area [45].…”

Section: Potential Role Of Cutaneous 40-to 100-mhz Sonographymentioning

confidence: 99%

“…It leads to overmodulation of signals from the epidermis [42], which in consequence fuse into one skin entry echo, typically appearing homogeneous in 20-MHz sonography [40,42]. Reduction of amplification usually results in a marked decrease in signal depth [42], but with a special computer program, preamplification levels can be varied depending on the skin layer studied, allowing sequential assessment of the epidermis and the complete dermis [39,42]. This technique is superior to multifrequency ultrasound systems -as developed by the working group around Turnbull [43,44] in which four transducers with frequencies between 40 and 100 MHz have to be exchanged [38,39].…”

Section: Potential Role Of Cutaneous 40-to 100-mhz Sonographymentioning

confidence: 99%

“…The latter is a requirement for the penetration depth needed for the assessment of dermis and subcutaneous fat [40]. It leads to overmodulation of signals from the epidermis [42], which in consequence fuse into one skin entry echo, typically appearing homogeneous in 20-MHz sonography [40,42]. Reduction of amplification usually results in a marked decrease in signal depth [42], but with a special computer program, preamplification levels can be varied depending on the skin layer studied, allowing sequential assessment of the epidermis and the complete dermis [39,42].…”

Section: Potential Role Of Cutaneous 40-to 100-mhz Sonographymentioning

confidence: 99%

“…In 50-MHz B-scan sonography with varying preamplification, the skin entry echo of palmar skin disintegrates into two echo-rich lines with an echolucent layer in between [42].…”

Section: Potential Role Of Cutaneous 40-to 100-mhz Sonographymentioning

confidence: 99%

“…The upper echolucent layer represents the stratum corneum [42], which is about 100 Ìm thick in the fingertip area [45]. The transition between the stratum corneum and the water-rich malpighian stratum provokes a fine echo-rich line [42].…”

Section: Potential Role Of Cutaneous 40-to 100-mhz Sonographymentioning

confidence: 99%

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High-Frequency Ultrasound in the Evaluation of Pharmacological Effects on the Skin

Unholzer

Körting²

2002

Skin Pharmacol Physiol

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In 1987, the introduction of two 20-MHz B- (brightness-) scan ultrasound systems with axial and lateral resolution of 200 µm and 75–80 µm, respectively, rendered two-dimensional sonographic imaging in dermatology possible. Since then cutaneous sonography has increasingly been used to investigate drug effects on human skin. Both unwanted and wanted effects have been studied, including skin thinning due to repeated glucocorticoid application and reduction of skin thickening in hyperplastic disorders such as psoriasis vulgaris due to various treatment approaches. The resolution of 20-MHz ultrasound is sufficient for studying pathological changes and pharmacological effects in the dermis and the subcutaneous fat; for assessing the epidermis, frequencies between 50 and 100 MHz may prove to be more effective.

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Section: Potential Role Of Cutaneous 40-to 100-mhz Sonographymentioning

confidence: 99%

Section: Potential Role Of Cutaneous 40-to 100-mhz Sonographymentioning

confidence: 99%

Section: Potential Role Of Cutaneous 40-to 100-mhz Sonographymentioning

confidence: 99%

“…In 50-MHz B-scan sonography with varying preamplification, the skin entry echo of palmar skin disintegrates into two echo-rich lines with an echolucent layer in between [42].…”

Section: Potential Role Of Cutaneous 40-to 100-mhz Sonographymentioning

confidence: 99%

Section: Potential Role Of Cutaneous 40-to 100-mhz Sonographymentioning

confidence: 99%

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High-Frequency Ultrasound in the Evaluation of Pharmacological Effects on the Skin

Unholzer

Körting²

2002

Skin Pharmacol Physiol

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20 MHz-Sonographie zur Verlaufskontrolle nach Shave-Therapie venöser Ulzera

Schmeller¹,

Wunderle²,

Welzel³

1998

Phlebologie

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ZusammenfassungMittels 20 MHz-Sonographie wurde bei 11 chronisch Venenkranken mit persistierenden Ulcera crurum der Befund vor und 2 Wochen bzw. 3 Monate nach Shave-Therapie (Ulkus- und Dermatoliposkleroseabtragung) dokumentiert. Als Vergleichsgruppe dienten 6 Venengesunde, bei denen ein Melanom am Unterschenkel operiert wurde. Bei den Venenkranken fand sich präoperativ am Ulkus-rand eine niedrige Echodichte in den oberen Bereichen der Dermatosklerose bzw. der Dermatoliposklerose; postoperativ nahm die Dichte im transplantierten Bereich kontinuierlich zu. Bei den Venengesunden erfolgte demgegenüber eine kontinuierliche Abnahme der präoperativ hohen Echodichte während des Heilungsverlaufs. Die gefundenen Unterschiede der Wundheilung werden als Folge der verschiedenen Ausbildung von postoperativen Ödemen, Entzündungen oder Narben angesehen.

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Different Skin Thinning Potential of Equipotent Medium-Strength Glucocorticoids

Körting

Unholzer

Schäfer‐Korting

et al. 2002

Skin Pharmacol Physiol

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In this study, we investigated the effect of prednicarbate, mometasone furoate and betamethasone 17-valerate on total skin thickness over a treatment period of 6 weeks. The study was conducted as a double-blind, placebo-controlled randomized clinical trial with a confirmatory approach. The influence of these drugs on healthy human skin under non-occlusive conditions was assessed by measuring total skin thickness and epidermal thickness using 20 and 50 MHz sonography, respectively. Epidermal surface structure was evaluated using profilometry. Visual assessment addressed signs of atrophy and formation of telangiectasia. The reduction of total skin thickness induced by prednicarbate was clearly less than that caused by betamethasone 17-valerate and mometasone furoate. Prednicarbate led to a higher degree of skin thinning than vehicle. For technical reasons, epidermal thickness could not be reliably evaluated with 50 MHz sonography. Profilometry did not demonstrate any differences between treatments. Visible signs of atrophy or telangiectasia were detected in two subjects each upon betamethasone 17-valerate and mometasone furoate, but not upon prednicarbate or its vehicle. Prednicarbate is a topical glucocorticoid with an improved benefit/risk ratio, as it causes less skin atrophy than the equipotent betamethasone 17-valerate.

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Bildgebende Verfahren in der Dermatologie

Cited by 3 publications

References 11 publications

High-Frequency Ultrasound in the Evaluation of Pharmacological Effects on the Skin

High-Frequency Ultrasound in the Evaluation of Pharmacological Effects on the Skin

20 MHz-Sonographie zur Verlaufskontrolle nach Shave-Therapie venöser Ulzera

Different Skin Thinning Potential of Equipotent Medium-Strength Glucocorticoids

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