1988
DOI: 10.1080/00021369.1988.10868729
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Bile Acid-binding Protein from Soybean Seed: Isolation, Partial Characterization and Insulin-stimulating Activity

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Cited by 33 publications
(19 citation statements)
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“…It is therefore reasonable to assume that food protein quality can be improved by introducing a favorable oligopeptide sequence through site-directed mutagenesis of the genes. Makino and co-workers 4,5) have reported that acidic polypeptides A1a and A2 had bile acid-binding abilities, and we have confirmed this. 3) In the present study, we introduced the VAWWMY sequence into glycinin A1a polypeptide to improve its bile acid-binding ability and also investigated attainment of the correct conformation for proglycinin A1aB1b with the VAWWMY sequence.…”
supporting
confidence: 86%
“…It is therefore reasonable to assume that food protein quality can be improved by introducing a favorable oligopeptide sequence through site-directed mutagenesis of the genes. Makino and co-workers 4,5) have reported that acidic polypeptides A1a and A2 had bile acid-binding abilities, and we have confirmed this. 3) In the present study, we introduced the VAWWMY sequence into glycinin A1a polypeptide to improve its bile acid-binding ability and also investigated attainment of the correct conformation for proglycinin A1aB1b with the VAWWMY sequence.…”
supporting
confidence: 86%
“…This hydrophobic region is also highly conserved in the A2 subunit. The suggestion that this hydrophobic region provides a binding site for bile acids is consistent with the previous observation 8 ) that 37-kDa protein interacts hydrophobically with bile acids.…”
Section: Identification Of Insulin-modulating Soybean Proteinsupporting
confidence: 91%
“…Furthermore, Sugano et al (22) have isolated a high-molecular weight fraction from soybean protein that stimulates fecal bile acid and neutral steroid excretion and is more hypocholesterolemic than equal amounts of intact soybean protein when fed to rats. There is indirect evidence that the high-molecular weight fraction of soybean protein, which is a hydrophobic peptide, may bind bile acids in the intestine (23). However , the high molecular weight fraction of soybean protein is rich in saponins (22) which may have contributed to the cholesterol lowering activity of this fraction.…”
Section: Fecal Excretion Of Bile Acids and Neutral Steroidsmentioning
confidence: 99%