2024
DOI: 10.21203/rs.3.rs-4716083/v1
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Bile acid-mediated activation of hepatic stellate cells and myeloid cell leukemia- 1 triggers hepatocarcinogenesis

Yuri Cho,
Minjong Lee,
Min Ji Park
et al.

Abstract: Objective Activated hepatic stellate cells (HSCs) promote hepatocellular carcinoma (HCC) cell growth and migration. Senescent and cancer-associated fibroblasts express various factors contributing to tumor progression, collectively called the senescence-associated secretory phenotype (SASP). Herein, we investigated the mechanism underlying the bile acid-mediated induction of HSC activation via SASP expression in HCC cells. Methods Serum samples from 296 patients with HCC were used to analyze IL-6 levels and … Show more

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