Bile Acid—Mediated Postcholecystectomy Diarrhea

Arlow, Freda L.; Dekovich, Alexander A.; Priest, Robert J.; Beher, William T.

doi:10.1001/archinte.1987.00370070139021

Cited by 42 publications

(20 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…5-17 However, the occurrence of bile acid malabsorption in our collagenous colitis patients showed no statistical association with sex, presence of autoimmune disease, or age. The association between bile acid malabsorption and cholecystectomy or gastric resection has been described previously,22 28 although the present study shows that collagenous colitis might also contribute to diarrhoea in these patients.…”

Section: Discussionsupporting

confidence: 67%

Role of bile acids and bile acid binding agents in patients with collagenous colitis

Ung

2000

Gut

192

145

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 67%

Role of bile acids and bile acid binding agents in patients with collagenous colitis

Ung

2000

Gut

192

145

View full text Add to dashboard Cite

show abstract

“…This includes a continuous flux of hepatic bile into the duodenum combined with bile acid malabsorption due to saturation of the reabsorptive capacity in the distal ileum, resulting in increased amounts of bile acids presented to the large bowel causing secretory diarrhoea and acceleration of colonic passage. In addition, psychological and psychosomatic factors influence gut motility 15 23 24…”

Section: Discussionmentioning

confidence: 99%

Quality of life and psychological and gastrointestinal symptoms after cholecystectomy: a population-based cohort study

Talseth

Edna

Hveem

et al. 2017

BMJ Open Gastroenterol

View full text Add to dashboard Cite

ObjectiveThe study aims to examine gastrointestinal symptoms, quality of life and the risk of psychological symptoms after cholecystectomy.DesignThis is a prospective population-based cohort study based on the Nord-Trøndelag Health Study (HUNT) Norway. HUNT is a repeated health survey of the county population and includes a wide range of health-related items. In the present study, all 3 HUNT surveys were included, performed between 1984 and 2008. Selected items were scores on quality of life, the Hospital Anxiety and Depression Scale (HADS) and selected gastrointestinal symptoms. Participants who underwent cholecystectomy for gallstone disease between 1 January 1990 and until 1 year before attending HUNT3 were compared with the remaining non-operated cohort. Associations between cholecystectomy and the postoperative scores and symptoms were assessed by multivariable regression models.ResultsParticipants in HUNT1, HUNT2 and HUNT3 were 77 212 (89.4% of those invited), 65 237 (69.5%) and 50 807 (54.1%), respectively. In the study period, 931 participants were operated with cholecystectomy. Cholecystectomy was associated with an increased risk of diarrhoea and stomach pain postoperatively. In addition, cholecystectomy was associated with an increased risk of nausea postoperatively in men. We found no associations between cholecystectomy and quality of life, symptoms of anxiety and depression, constipation, heartburn, or acid regurgitation following surgery.ConclusionsIn this large population-based cohort study, cholecystectomy was associated with postoperative diarrhoea and stomach pain. Cholecystectomy for gallstone colic was associated with nausea in men. There were no associations between quality of life, symptoms of anxiety and depression, constipation, heartburn, or acid regurgitation.

show abstract

“…The basic reasons for post-cholecystectomy diarrhea may be associated with, firstly, the malabsorption of bile acid [49][50][51], which would increase bile acid presenting to the large bowel [52], and secondly, shortening of the gut transit time by accelerating passage through the colon [53]. However, older age, smoking, longer operative time, and follow-up period were identified as protection factors in frequent diarrhea.…”

Section: Discussionmentioning

confidence: 99%

Transumbilical single-incision laparoscopic cholecystectomy: long-term review from a single center

Tian

et al. 2015

Surg Endosc

View full text Add to dashboard Cite

show abstract

Bile Acid—Mediated Postcholecystectomy Diarrhea

Cited by 42 publications

References 16 publications

Role of bile acids and bile acid binding agents in patients with collagenous colitis

Role of bile acids and bile acid binding agents in patients with collagenous colitis

Quality of life and psychological and gastrointestinal symptoms after cholecystectomy: a population-based cohort study

Transumbilical single-incision laparoscopic cholecystectomy: long-term review from a single center

Contact Info

Product

Resources

About