Bile Acid Metabolism in Hyperlipidemia Mice Effects of Lipid-Lowering Lactobacillus Plantarum DC4

Abstract

The purpose of this experiment was to study the changes of bile acid metabolism during the lipid-lowering process of Lactobacillus plantarum DC4. To analyze the body effect of Lactobacillus plantarum DC4 regulating cholesterol metabolism, and to explore the metabolic network pathways it participates in or regulates, and to preliminarily elucidate its mechanism of regulating cholesterol metabolism. Taking the intervention of bile acid metabolism network as the starting point, the effects of Lactobacillus plantarum DC4 on abnormal lipid metabolism and bile acid profile in hyperlipidemia mice were investigated. Combined with QPCR technology, the metabolomics characteristics of bile acids before, during and after Lactobacillus plantarum DC4 intervention were studied to find related and co-changed metabolites and influencing pathways, and to elucidate the mechanism of Lactobacillus plantarum DC4 improving lipid metabolism in hyperlipidemia mice.