2006
DOI: 10.1016/j.jss.2005.09.024
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Bile Acid Promotes the Proliferation of Squamous Cell Carcinoma of the Esophagus, Independent of its Inducing COX-2 Expression

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Cited by 12 publications
(13 citation statements)
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References 36 publications
(41 reference statements)
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“…The biphasic effect of CDCA on cell proliferation is of interest in light of recent findings by Nishioka et al (35). These authors suggest that CDCA stimulated proliferation of squamous cell carcinomas at low concentrations, while having a profound effect on the inhibition of cell proliferation at concentrations Ͼ30 M. Those results are in agreement with the present findings as far as the regulation of cell proliferation is concerned.…”
Section: Discussionsupporting
confidence: 93%
“…The biphasic effect of CDCA on cell proliferation is of interest in light of recent findings by Nishioka et al (35). These authors suggest that CDCA stimulated proliferation of squamous cell carcinomas at low concentrations, while having a profound effect on the inhibition of cell proliferation at concentrations Ͼ30 M. Those results are in agreement with the present findings as far as the regulation of cell proliferation is concerned.…”
Section: Discussionsupporting
confidence: 93%
“…In brief, bile acid at a low dose stimulates the proliferation of ESCC by inducing G1‐regulating molecules such as cyclin D1, CDC25A and Rb. This biphasic reaction may reflect the clinical aspects of the bile acid effect on the squamous epithelium of the esophagus, that is, carcinogenesis (low concentration) and inflammation (high concentration) 37…”
Section: Discussionmentioning
confidence: 99%
“…Nishioka et al reported that CDCA stimulates proliferation of ESCC cells (TE2R, TE3, TE13, and TE15) through a mechanism involving regulation of the G1 phase [38]. In contrast, Zhang et al showed that 3-day exposure to CA, DCA, TCA, TDCA, taurochenodeoxycholic acid, GDCA, or glycochenodeoxycholic acid (50–500 µM) inhibits growth and induces apoptosis in ESCC cells (Eca109) [39].…”
Section: Discussionmentioning
confidence: 99%