Bile Acids Alter the Autophagy and Mitogenesis in Skeletal Muscle Cells

Tacchi, Franco; Orozco-Aguilar, Josué; Valero-Breton, Mayalen; Cabello-Verrugio, Claudio

doi:10.1007/978-3-031-26163-3_10

Cited by 2 publications

(1 citation statement)

References 88 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…BA profiling showed that lean NAFLD patients had lower levels of deoxycholic acid (DCA), glycodeoxycholic acid (GCDCA) and goosenodeoxycholic acid (CDCA), and higher levels of glycocholic acid (GCA) (3). Studies reported that serum cholic acid (CA), ursodeoxycholic acid (UDCA) and DCA impair muscle fiber structure and function and induce sarcopenia (138)(139)(140). And the level of CA is significantly higher in patients with severe fibrosis compared with those with none/mild fibrosis (3).…”

Section: Differential Metabolitesmentioning

confidence: 99%

Lean nonalcoholic fatty liver disease and sarcopenia

Chen

et al. 2023

Front. Endocrinol.

View full text Add to dashboard Cite

Nonalcoholic fatty liver disease (NAFLD) has become one of the most common chronic liver diseases in the world. The risk factor for NAFLD is often considered to be obesity, but it can also occur in people with lean type, which is defined as lean NAFLD. Lean NAFLD is commonly associated with sarcopenia, a progressive loss of muscle quantity and quality. The pathological features of lean NAFLD such as visceral obesity, insulin resistance, and metabolic inflammation are inducers of sarcopenia, whereas loss of muscle mass and function further exacerbates ectopic fat accumulation and lean NAFLD. Therefore, we discussed the association of sarcopenia and lean NAFLD, summarized the underlying pathological mechanisms, and proposed potential strategies to reduce the risks of lean NAFLD and sarcopenia in this review.

show abstract