Bile Acids and Bilirubin in Liver Immunology

Zhu, Ci; Claudel, Thierry; Trauner, Michael

doi:10.1007/978-3-030-51709-0_7

Cited by 1 publication

(1 citation statement)

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“…Bilirubin is an important component of bile and acts as an antioxidant. It can form a part of the enterohepatic circulation and be actively secreted by hepatocytes [45]. The stored bile acids are released into the duodenum via cholecystokinin (CCK), which binds to the CCK receptor in the gall bladder and induces its contraction for emptying [46].…”

Section: Enterohepatic Circulation Dynamicsmentioning

confidence: 99%

Bile Acids and Microbiota Interplay in Pancreatic Cancer

Malhotra

Palanisamy

Caparrós-Martín

et al. 2023

Cancers

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Evidence suggests the involvement of the microbiota, including oral, intra-tumoral and gut, in pancreatic cancer progression and response to therapy. The gut microbiota modulates the bile acid pool and is associated with maintaining host physiology. Studies have shown that the bile acid/gut microbiota axis is dysregulated in pancreatic cancer. Bile acid receptor expression and bile acid levels are dysregulated in pancreatic cancer as well. Studies have also shown that bile acids can cause pancreatic cell injury and facilitate cancer cell proliferation. The microbiota and its metabolites, including bile acids, are also altered in other conditions considered risk factors for pancreatic cancer development and can alter responses to chemotherapeutic treatments, thus affecting patient outcomes. Altogether, these findings suggest that the gut microbial and/or bile acid profiles could also serve as biomarkers for pancreatic cancer detection. This review will discuss the current knowledge on the interaction between gut microbiota interaction and bile acid metabolism in pancreatic cancer.

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Section: Enterohepatic Circulation Dynamicsmentioning

confidence: 99%