Bile acids and colonic motility in the rabbit and the human.

Kirwan, W. O.; Smith, A. N.; Mitchell, W. D.; Falconer, Jackie; Eastwood, M. A.

doi:10.1136/gut.16.11.894

Cited by 135 publications

(84 citation statements)

References 8 publications

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“…The increase motility in this study supported also by Kirwan et al (1975), who found that the abnormally high quantities of primary BAs in the colon cause diarrhea not only by inhibiting the absorption of water and electrolytes, but also by eliciting colonic motor activity.…”

Section: Discussionsupporting

confidence: 72%

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Effect of cholic acid on colonic motility in mice

Abdu¹

2013

Afr. J. Pharm. Pharmacol.

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The role of bile acids on the gastrointestinal motility are contradictory, especially the role of mast cells mediators in this effect. Thus, cholic acid (CA) was examined for its in vitro action on the motility of the mice colon using different doses of CA (0.3, 30, 50, 100, 200, 300 and 500 µM). The contractile activity of the colon segment was recorded as changes in intraluminal pressure under isovolumetric conditions. The mean amplitude of the peristaltic motor complexes and the frequency (interval) of phasic contractions were determined. In other experiments, to study the CA mode of action, tissues were preincubated with 5-HT3 antagonist (Granisetron hydrochloride), 5-HT4 antagonist (GR113808), H1 antagonist (Pyrilamine maleate salt) and protease activated receptor (PAR1) antagonist (BMS-200261) prior to challenge with CA (300 µM). CA inhibitory effect on contractile activity might be via its antagonistic action on the 5-HT3, 5-HT4, H1 receptors and PAR1 with variable levels. In conclusion, CA perfusion, at certain concentration levels, induced significant physiological changes in colon motility that might propose its antagonistic action on the receptors of the mast cells neuromediators.

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Section: Discussionsupporting

confidence: 72%

“…Early in vivo studies showed that BAs either stimulate motility or have no effect (Feldman and Gibaldi, 1968;Kirwan et al, 1975 andFalconer et al, 1980). In vitro researches demonstrated that BAs inhibit contractions of rabbit and guinea pig intestine (Armstrong et al, 1993;Romero et al, 1993;Poole et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Effect of cholic acid on colonic motility in mice

Abdu¹

2013

Afr. J. Pharm. Pharmacol.

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“…Controlled trials on the use of appetite suppressants such as amphetamines have shown a variety ofundesirable side effects including central nervous stimulation, addiction, toxicity, euphoria and even ineffectiveness. The use of amphetamines has been discouraged but fenfluramine, an analogue of amphetamine, has become widely used as an anti-obesity agent devoid of central nervous stimulation (Munro, Seaton and Duncan, 1966;Le Douarec and Niven, 1970). There are reports of its beneficial effects on hyperlipidaemia (Pawan, 1969;Bliss, Kirk and Newall, 1972), on hypercholesterolaemia (Tomlinson, Lines and Greenfield, 1975), and on hyperglycaemia (Turtle, 1972).…”

Section: Introductionmentioning

confidence: 99%

Bile acid, neutral sterol and faecal fat excretion in subjects treated with fenfluramine and its relationship to fenfluramine-induced diarrhoea

Sian

Rains

1979

Postgraduate Medical Journal

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SummaryBile acid, neutral sterol and faecal fat excretion was studied over a period of 9 weeks in a group of 16 healthy subjects before, during and after administration of fenfluramine. Statistical analysis revealed a significant increase in bile acid excretion during the drug phase (P<0.02); and during recovery period of 3 weeks (P< 0-05). Faecal neutral sterol, as the total of coprostanol and cholesterol elimination was also enhanced after fenfluramine. Coprostanol was replaced by cholesterol in 12 subjects. Faecal fat was studied in 6 subjects, the excretion increased during the drug phase (P< 005), and remained elevated during the post-drug period (P< 001). The composition of the bile acids remained unaltered in all the subjects except 3 who had a fenfluramine-induced watery diarrhoea; and these excreted chenodeoxy and cholic together with smaller amounts of secondary bile acids. A higher excretion of bile acids was found in the 8 overweight subjects (P<0.01) before ministration of fenfluramine.These results are discussed in an attempt to correlate the effect of fenfluramine with changes in bile acid and neutral sterol excretion, and its relationship to fenfluramine-induced diarrhoea.

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“…Bile acids have a direct secretory effect on colonic enterocytes, 3 and indirectly induce a secretory response by stimulating mast cells or intrinsic neural arcs. 4,5 In addition, the introduction of bile acids into the human sigmoid colon and rectum stimulates colonic motility, 6 and chenodeoxycholate significantly accelerates colon transit time in healthy subjects. 7 A failure to reabsorb bile acid was also suggested to be a cause of diarrhea owing to excess bile acids entering the colon.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Deoxycholic Acid on Secretion and Motility in the Rat and Guinea Pig Large Intestine

Kim

Park

et al. 2017

J Neurogastroenterol Motil

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Background/AimsBile acid is an important luminal factor that affects gastrointestinal motility and secretion. We investigated the effect of bile acid on secretion in the proximal and distal rat colon and coordination of bowel movements in the guinea pig colon. MethodsThe short-circuit current from the mucosal strip of the proximal and distal rat colon was compared under control conditions after induction of secretion with deoxycholic acid (DCA) as well as after inhibition of secretion with indomethacin, 1,2-bis (o-aminophenoxy) ethane-N,N,N′,N′-tetra-acetic acid (an intracellular calcium chelator; BAPTA), and tetrodotoxin (TTX) using an Ussing chamber. Colonic pressure patterns were also evaluated in the extracted guinea pig colon during resting, DCA stimulation, and inhibition by TTX using a newly developed pressure-sensing artificial stool. ResultsThe secretory response in the distal colon was proportionate to the concentration of DCA. Also, indomethacin, BAPTA, and TTX inhibited chloride secretion in response to DCA significantly (P < 0.05). However, these changes were not detected in the proximal colon. When we evaluated motility, we found that DCA induced an increase in luminal pressure at the proximal, middle, and distal sensors of an artificial stool simultaneously during the non-peristaltic period (P < 0.05). In contrast, during peristalsis, DCA induced an increase in luminal pressure at the proximal sensor and a decrease in pressure at the middle and distal sensors of the artificial stool (P < 0.05). Conclusions

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Bile acids and colonic motility in the rabbit and the human.

Cited by 135 publications

References 8 publications

Effect of cholic acid on colonic motility in mice

Effect of cholic acid on colonic motility in mice

Bile acid, neutral sterol and faecal fat excretion in subjects treated with fenfluramine and its relationship to fenfluramine-induced diarrhoea

The Effect of Deoxycholic Acid on Secretion and Motility in the Rat and Guinea Pig Large Intestine

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