Bile Acids and the Intestinal Kallikrein-Kinin System

Zeitlin, I. J.; Al-Dhahir, H. A. R.; Cook, Stuart; Currie, A.; Donovan, K.

doi:10.1007/978-1-4684-5143-6_7

Cited by 2 publications

(2 citation statements)

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“…Schachter et al (1983Schachter et al ( , 1986) have localized kallikreinlike enzymes in the colon to the goblet cells, as is the case in stomach and intestine. The demonstration of local synthesis does not preclude the possibility that some portion of the kallikrein-like activity reported in the gastrointestinal tract (Uchida et al, 1980;Uetsuji et al, 1982;Schachter et al, 1983Schachter et al, , 1986Skagen & Andersen, 1986;Zeitlin et al, 1986), particularly the upper region, is derived from exocrine-gland secretions.…”

Section: Discussionmentioning

confidence: 99%

“…Glandular kallikreins are arginine-bond-specific esteropeptidases involved in the processing of prohormone precursors to their bioactive end products [for reviews, see Schachter (1980), , Isackson et al (1987) and MacDonald et al (1988)]. Kallikrein-like enzyme activity has been demonstrated in various regions of the rat gastrointestinal tract (Zeitlin et al, 1986). This activity has been purified from rat and human gastric mucosa (Uchida et al, 1980;Uetsuji et al, 1982).…”

Section: Introductionmentioning

confidence: 99%

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Kallikrein-gene expression in the rat gastrointestinal tract

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Matheson

et al. 1989

Biochemical Journal

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The serine proteinase glandular kallikrein has been demonstrated in the gastrointestinal tract, although there is some doubt as to whether it is synthesized there or derives from exocrine-gland secretions. Using a rat pancreatic kallikrein cRNA probe we have demonstrated kallikrein-like gene expression in the corpus, duodenum, jejunum, ileum, caecum and colon, and compared the pattern of expression with that of the gastrointestinal peptides somatostatin, gastrin and glucagon. In addition, using a panel of oligonucleotide probes specific for various members of the rat kallikrein-gene family, we have shown that the kallikrein-like gene expressed appears to be expressed as true kallikrein.

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