Bile acids as metabolic regulators

Li, Tiangang; Chiang, John Y.L.

doi:10.1097/mog.0000000000000156

Cited by 238 publications

(189 citation statements)

References 67 publications

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“…5 Through activation of these 2 receptors, bile acids regulate their own synthesis, conjugation, transport and detoxification, as well as lipid, glucose, and energy homeostasis. 6 Furthermore, bile acids play an important role in maintaining intestinal barrier function, as antimicrobial agents that help determine the gut microbiome structure, and as inducers of genes encoding anti-microbial peptides and lectins via FXR. 7 …”

Section: Introductionmentioning

confidence: 99%

Consequences of bile salt biotransformations by intestinal bacteria

et al. 2016

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Section: Introductionmentioning

confidence: 99%

Consequences of bile salt biotransformations by intestinal bacteria

et al. 2016

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“…Regulation of plasma TC levels and BA metabolism are tightly linked as cholesterol from plasma serves as substrate for de novo BA synthesis in the liver 46, 47. Increased fecal excretion of BAs thus requires increased production of BAs.…”

Section: Discussionmentioning

confidence: 99%

Dietary Mannan Oligosaccharides Modulate Gut Microbiota, Increase Fecal Bile Acid Excretion, and Decrease Plasma Cholesterol and Atherosclerosis Development

Hoving

Katiraei

Heijink

et al. 2018

Molecular Nutrition Food Res

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ScopeMannan oligosaccharides (MOS) have proven effective at improving growth performance, while also reducing hyperlipidemia and inflammation. As atherosclerosis is accelerated both by hyperlipidemia and inflammation, we aim to determine the effect of dietary MOS on atherosclerosis development in hyperlipidemic ApoE*3‐Leiden.CETP (E3L.CETP) mice, a well‐established model for human‐like lipoprotein metabolism.Methods and resultsFemale E3L.CETP mice were fed a high‐cholesterol diet, with or without 1% MOS for 14 weeks. MOS substantially decreased atherosclerotic lesions up to 54%, as assessed in the valve area of the aortic root. In blood, IL‐1RA, monocyte subtypes, lipids, and bile acids (BAs) were not affected by MOS. Gut microbiota composition was determined using 16S rRNA gene sequencing and MOS increased the abundance of cecal Bacteroides ovatus. MOS did not affect fecal excretion of cholesterol, but increased fecal BAs as well as butyrate in cecum as determined by gas chromatography mass spectrometry.ConclusionMOS decreased the onset of atherosclerosis development via lowering of plasma cholesterol levels. These effects were accompanied by increased cecal butyrate and fecal excretion of BAs, presumably mediated via interactions of MOS with the gut microbiota.

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“…They stimulate bile secretion and are required for the intestinal absorption of lipids and fat-soluble vitamins. BAs also modulate gene expression through signal transduction pathways that regulate lipid metabolism and energy expenditure (1). However, when BA excretion is disrupted, they accumulate in the liver and systemic circulation and cause cholestatic liver injury that often leads to progressive liver damage and subsequent liver failure.…”

Section: Introductionmentioning

confidence: 99%