Bile duct carcinogenesis after excision of extrahepatic bile ductsin pancreaticobiliary maljunction

Ng, W. T.

doi:10.1067/msy.2000.108676

Cited by 13 publications

(21 citation statements)

References 2 publications

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“…More than 40% of patients with recurrence developed CC-associated cancer, and these patients had poor long-term survival. Similar to previous reports, 14,23,24 development of biliary cancer after CC resection was predominantly seen in patients with type I and IV cysts. Although the risk of biliary cancer is reduced with operative resection of CCs, 15 the risk of malignancy does not return to baseline population levels.…”

Section: Discussionsupporting

confidence: 90%

Presentation and Clinical Outcomes of Choledochal Cysts in Children and Adults

et al. 2015

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Section: Discussionsupporting

confidence: 90%

Presentation and Clinical Outcomes of Choledochal Cysts in Children and Adults

et al. 2015

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“…Additionally, the malignant risk due to the presence of an APBJ has been well established in both Western and Eastern patients. At our institution, we have observed a 4-fold increase in malignancy in patients with CC and an APBJ when compared to those with CC without an APBJ[41]. Imazu et al[29] showed that regurgitation and stasis of pancreatic fluid into the biliary system not only cause inflammation, but lead to carcinogenesis.…”

Section: Malignant Riskmentioning

confidence: 99%

“…A small subset of patients, from 0.7%-3%, develop cholangiocarcinoma after surgical resection, notably in patients with type I and IV cysts[11,15,24,41]. This indicates that the risk of malignancy does not return to baseline after CC resection in this group of patients[11,42].…”

Section: Malignant Riskmentioning

confidence: 99%

Choledochal cysts: Similarities and differences between Asian and Western countries

Baison¹,

Bonds²,

Helton³

et al. 2019

WJG

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Choledochal cysts (CCs) are rare bile duct dilatations, intra-and/or extrahepatic, and have higher prevalence in the Asian population compared to Western populations. Most of the current literature on CC disease originates from Asia where these entities are most prevalent. They are thought to arise from an anomalous pancreaticobiliary junction, which are congenital anomalies between pancreatic and bile ducts. Some similarities in presentation between Eastern and Western patients exist such as female predominance, however, contemporary studies suggest that Asian patients may be more symptomatic on presentation. Even though CC disease presents with an increased malignant risk reported to be more than 10% after the second decade of life in Asian patients, this risk may be overstated in Western populations. Despite this difference in cancer risk, management guidelines for all patients with CC are based predominantly on observations reported from Asia where it is recommended that all CCs should be excised out of concern for the presence or development of biliary tract cancer.

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“…Ng listed all reported cases of postexcisional carcinoma, including 8 type IVa cysts (40%), 4 type IV cysts (17.5%), 7 type I cysts (35%), and 1 type Ia cyst (5%). 56 The author recommended the total excision of the dilated bile duct down to its confluence with the pancreatic duct. Shimamura et al and Kumamoto et al reported on tumor transformation following Todani type IVa choledochal cyst excision.…”

Section: Impact Of Initial Type Of Cystmentioning

confidence: 99%

Choledochal Cyst and Malignancy: A Plea for Lifelong Follow-Up

et al. 2017

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Previous research has confirmed that patients with choledochal cyst have an elevated risk of cholangiocarcinoma and gallbladder carcinoma. Current data suggest a risk of malignancy of 6 to 30% in adults with choledochal cyst. Malignancy has also occasionally been identified in children and adolescents. Multiple factors, including the age of the patient, cyst type, histological findings, and localization, have an impact on the prognosis. Information on long-term outcomes after cyst excision is limited. However, recent data suggest a lifelong elevated risk of up to 4% of cancer development following operation. This paper presents a review of the literature on cancer in patients with choledochal cyst before and after excision. A postoperative follow-up concept that consists of annual controls of CA19-9 and abdominal ultrasound is introduced.

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Bile duct carcinogenesis after excision of extrahepatic bile ductsin pancreaticobiliary maljunction

Cited by 13 publications

References 2 publications

Presentation and Clinical Outcomes of Choledochal Cysts in Children and Adults

Presentation and Clinical Outcomes of Choledochal Cysts in Children and Adults

Choledochal cysts: Similarities and differences between Asian and Western countries

Choledochal Cyst and Malignancy: A Plea for Lifelong Follow-Up

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