Bile induced chronic gastric ulcer in swine

Abstract

The role of bile in the pathogenesis of chronic gastric ulcer was studied in 10 grown-up miniature pigs. After an observation period of 14-186 days, 4 pigs out of $ with total diversion of bile into the stomach developed peptic ulcers in the glandular part of the stomach, whereas none of 5 sham operated pigs developed ulcers after an observation period of 150-196 days. This difference was significant (p <0.05). In all 5 pigs with bile diversion the pyloric gland area enlarged at the cost of the fundic gland area, whereas this was not the case in the 5 controls. This difference was also significant (p (0.01). There was no significant change in gastric emptying after the operations. It is concluded that bile can cause gastric ulcer in the pig.

Intestino-gastric Reflux in Dogs: Spontaneous, after Gastrojejunostomy, and after Roux-en-Y Gastrojejunostomy with Various Lengths of the Defunctioning Loop

“…This so-called 'chronic gastric mucosal reaction' is considered a precursor of gastric ulceration (1 l), and in this laboratory we have found the same histologic changes in pigs with chronic gastric ulceration after diversion of bile into the stomach (28). The histologic effect of this reflux has especially been studied by DuPlessis and Lawson (1 1, 2 1, 22), who described a pseudopyloric metaplasia with replacement of the chief and parietal cells by mucous cells.…”

A survey of the relationship between bile staining and oesophagogastric lesions in slaughter pigs

“…On the basis of their observations and the suggested relationship between bile regurgitation and stomach ulcers in humans (2,4,12), Reed and Kidder (11) hypothesized that the regurgitation of bile into the stomach might be causally linked to the occurrence of oesophagogastric lesions in fattening pigs. Rokkjaer et al (13,14) produced chronic gastric ulcers in miniature swine in an experimental setting with total diversion of bile into the stomach. However, the gastric ulcers were produced in the gladular part of the stomach, not in the parsoesophagea.…”

Tierexperimentelle Untersuchungen zur Genese von Anastomosenulzera nach refluxbelasteter und refluxverh�tender Magenresektion

“…Eine durch Galle bedingte Gewebesch/idigung wies M. Smith 1914 nach [26]. Auch M. Rokkjaer [23] beobachtete nach 14-186 Tage bei 4 yon 5 Schweinen mit intakten M/igen und gleichzeitiger Cholezystogastromie gastrale Ulzera der Pars pylorica (Antrum). Auch M. Rokkjaer [23] beobachtete nach 14-186 Tage bei 4 yon 5 Schweinen mit intakten M/igen und gleichzeitiger Cholezystogastromie gastrale Ulzera der Pars pylorica (Antrum).…”

“…Mit 30 38 Tagen war die Latenz bis zur Ulkusentwicklung jedoch kiirzer als von Rokkjaer [23] beschrieben. Zus/itzlich zeigten sich ausgepr/igte erosive/ulzer6se L/isionen der Magenschleimhaut im Bereich der Cholezystogastrostomie.…”

“…Experimentell erwiesen sich Gallens/iurenkonzentrationen von fiber 2,5 mmol/1 als zytotoxisch [23]. In der eigenen Untersuchung fiberschritt die mediane Ge-samtgallens/iurenkonzentration mit 39,3 retool/1 nach B-[-Resektion diesen Wert deutlich, ohne zu Schleimhautl/isionen zu ffihren.…”