Bile salt assisted morphological changes of cationic gemini surfactant (12-4-12) micelles

Padasala, Shailesh; Patel, Vipul M.; Ray, Debes; Singh, Kulbir; Aswal, Vinod K.; Bahadur, Pratap

doi:10.1039/c6ra17212a

Cited by 18 publications

(2 citation statements)

References 55 publications

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“…The most widespread bile salts considered in recent reports are cholate, deoxycholate and taurodeoxycholate. Sodium cholate is known for its capability to act as a transdermal enhancer [ 84 ] and additive to mono- and dicationic surfactant solutions significantly modifying their morphological behavior [ 85 ] and release profile of cargo encapsulated in self-assembled drug nanovehicles [ 86 ]. Sodium deoxycholate was reported as part of biamphiphiles, ionic compounds with both cationic and anionic amphiphilic nature, which aggregate shape could be accurately controlled [ 87 ]; micellar catalyst for the synthesis of 1,2,3-triazole derivatives; their characteristics is superior in comparison with those of conventional surfactants CTAB and Triton-X-100 [ 88 ].…”

Section: Self-assembly Of Amphiphilic Compoundsmentioning

confidence: 99%

Self-Assembly of Amphiphilic Compounds as a Versatile Tool for Construction of Nanoscale Drug Carriers

Kashapov

Gaynanova

Gabdrakhmanov

et al. 2020

IJMS

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This review focuses on synthetic and natural amphiphilic systems prepared from straight-chain and macrocyclic compounds capable of self-assembly with the formation of nanoscale aggregates of different morphology and their application as drug carriers. Since numerous biological species (lipid membrane, bacterial cell wall, mucous membrane, corneal epithelium, biopolymers, e.g., proteins, nucleic acids) bear negatively charged fragments, much attention is paid to cationic carriers providing high affinity for encapsulated drugs to targeted cells. First part of the review is devoted to self-assembling and functional properties of surfactant systems, with special attention focusing on cationic amphiphiles, including those bearing natural or cleavable fragments. Further, lipid formulations, especially liposomes, are discussed in terms of their fabrication and application for intracellular drug delivery. This section highlights several features of these carriers, including noncovalent modification of lipid formulations by cationic surfactants, pH-responsive properties, endosomal escape, etc. Third part of the review deals with nanocarriers based on macrocyclic compounds, with such important characteristics as mucoadhesive properties emphasized. In this section, different combinations of cyclodextrin platform conjugated with polymers is considered as drug delivery systems with synergetic effect that improves solubility, targeting and biocompatibility of formulations.

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Section: Self-assembly Of Amphiphilic Compoundsmentioning

confidence: 99%

Self-Assembly of Amphiphilic Compounds as a Versatile Tool for Construction of Nanoscale Drug Carriers

Kashapov

Gaynanova

Gabdrakhmanov

et al. 2020

IJMS

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“…The fascinating phase behavior of such mixed systems arises due to the interplay of the electrostatic interaction, hydrophobic interaction, H-bonding, and steric effect. The interaction of SAILs with cationic, , anionic, , nonionic, , Gemini, , Pluronic, − and Tetronic , surfactants has been investigated by several researchers. The synergistic interaction in the mixed systems comprising 1-dodecyl-3-methylimidazolium chloride (C 12 mimCl) with the nonionic surfactant Triton X-100 or Triton X-405 has been reported by Farahani et al and it was revealed that micellization is spontaneous in nature and more favorable in the presence of Triton X-100.…”

Section: Introductionmentioning

confidence: 99%

Synergistic Self-Assembly in a Surface-Active Ionic Liquid and an Anionic Surfactant Mixed System: A Comprehensive Physicochemical Analysis

Pathan,

Girase,

Patel

et al. 2024

Ind. Eng. Chem. Res.

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The present investigation is undertaken to develop and characterize mixed aggregates formed from a surface-active ionic liquid (SAIL), 1-hexadecyl-3-methylimidazolium chloride (C16mimCl), and two anionic surfactants, sodium oleate or sodium linoleate. The micellization behavior of the cationic SAIL and anionic surfactants was investigated using the tensiometric method. The obtained surface tension data have been analyzed by Rubingh’s regular solution theory (RST) and Clint’s theory for mixed binary systems. Surface tension data offer additional insight into the change in the critical micelle concentration (CMC) and surface activity as a function of the mole fraction of the SAIL. The negative value of interaction parameters and low CMC values imply the synergism between micelle-forming units at the all-mole fraction investigated. The interfacial and thermodynamic parameters for mixed micelles and mixed monolayers at various mole fractions of C16mimCl have been calculated and discussed. A thorough insight into the correlation between the molecular orbital energy level of C16mimCl and sodium oleate or sodium linoleate is provided by optimized parameters, which are obtained from a computational simulation approach. The obtained results highlight the compatibility of SAILs with anionic surfactants in formulating the mixed nanoaggregates for desired applications.

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Thermodynamics of self-aggregation of mixed cationic gemini/sodium deoxycholate surfactant systems in aqueous solution

Wang

et al. 2018

J Therm Anal Calorim

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Bile salt assisted morphological changes of cationic gemini surfactant (12-4-12) micelles

Abstract: pH and concentration dependent growth of gemini surfactant (12-4-12) micelles in the presence of bile salts.

Cited by 18 publications

References 55 publications

Self-Assembly of Amphiphilic Compounds as a Versatile Tool for Construction of Nanoscale Drug Carriers

Self-Assembly of Amphiphilic Compounds as a Versatile Tool for Construction of Nanoscale Drug Carriers

Synergistic Self-Assembly in a Surface-Active Ionic Liquid and an Anionic Surfactant Mixed System: A Comprehensive Physicochemical Analysis

Thermodynamics of self-aggregation of mixed cationic gemini/sodium deoxycholate surfactant systems in aqueous solution

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