Bile Salt‐Stimulated Lipase Activity in Human Colostrum from Mothers of Infants of Different Gestational Age and Birthweight

Abstract

The bile salt-stimulated lipase (BSSL) activity was measured in milk collected at 3-4 days postpartum (colostrum) from 36 mothers divided into three groups according to gestational age and birthweight of their infants. BSSL activity changed with the length of gestation. Preterm colostrum presented a mean activity significantly higher than the term groups (small-for-gestational age and appropriate-for-gestational age) which had similar values. The ratio of BSSL activity to the estimated fat content was 6.33 in colostrum of mothers who delivered preterm and 4.20 in colostrum of both groups of term mothers. These data suggest that preterm colostrum has a higher fat digesting potential than term colostrum and that it is the gestational age rather than the adequacy or non-adequacy of birthweight to gestational age that may influence the BSSL activity.

Triacylglycerols containing branched palmitic acid ester of hydroxystearic acid (PAHSA) are present in the breast milk and hydrolyzed by carboxyl ester lipase

“…Relative protein levels of CEL in colostrum were similar in VB and PB groups (Figure S1) in agreement with published data (49). However, the CEL activity was reported higher in preterm colostrum, resulting in a higher fat digesting potential during the early postnatal phase (50). Therefore, preterm colostrum might be optimized to help with the fat digestion at the expense of TAG estolides and FAHFAs.…”

Holder pasteurization impacts the proteolysis, lipolysis and disintegration of human milk under in vitro dynamic term newborn digestion

“…The action of endogenous lipases of the human milk is supposed to have positive effect on newborn nutrition since it improves lipid digestion. This natural potential for fat pre-digestion is particularly important in a context of digestive immaturity, in preterms and in the first weeks of life for instance (Pamblanco, Ten, & Comin, 1987). Hence the prelipolysis of the undigested human milk used in our study is certainly due to the action of endogenous lipases of human milk (i.e.…”

O/W Emulsion Stabilized by Bovine Milk Phospholipid–Protein Nanoemulsions: Preparation, Stability, and In Vitro Digestion

“…The action of endogenous lipases in human milk potentially contributed to the TAGs being more easily hydrolyzed. 35 At the end of the gastric phase (120 min), the O/W emulsion showed a lower LD (3.26%) than human milk and IF. This may be partially affected by the structure and size of the O/W emulsion droplets, and the emulsion interfacial composition also greatly affects its hydrolysis kinetics during gastric digestion.…”

“…Compared with the O/W emulsion and IF, human milk has a higher LD in the gastric phase, and the LD increased to 18.86% rapidly within 0–30 min (Figure A). The action of endogenous lipases in human milk potentially contributed to the TAGs being more easily hydrolyzed . At the end of the gastric phase (120 min), the O/W emulsion showed a lower LD (3.26%) than human milk and IF.…”