Bilharzial pseudotumors—Dramatic manifestation of schistosomiasis: Report of a case

Prosser, James M.; Kasznica, John; Gottlieb, Leonard S.; Wade, G. G.

doi:10.1016/0046-8177(94)90178-3

Cited by 7 publications

(4 citation statements)

References 7 publications

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Section: Resultsmentioning

confidence: 99%

“…After removing 104 duplicate records, 170 records were screened by title and abstract and 53 records were retrieved for full text screening. Seven records were excluded, of which three did not provide relevant data, [11][12][13] respiratory symptoms were attributed to other causes in two records 14,15 and respiratory symptoms specific for S. mansoni were not enumerated in the other two records. 16,17 Study characteristics A total of 2243 patients with S. mansoni were reported from 24 case reports (24 patients), 11 cross-sectional studies (1121 patients), 7 case series (45 patients), 2 cohort studies (53 patients) and 2 randomized controlled trials (1000 patients).…”

Section: Study Selectionmentioning

confidence: 99%

See 1 more Smart Citation

Respiratory morbidity in Schistosoma mansoni infection: a rapid review of literature

Baluku,

Olum,

Sanya

et al. 2023

Therapeutic Advances in Infection

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Background: Schistosomiasis contributes to 2.5 million disability-adjusted life years globally. Acute and chronic respiratory morbidity of Schistosoma mansoni ( S. mansoni) is poorly documented in the literature. We conducted a rapid literature review of the burden of respiratory symptoms and lung function abnormalities among patients with S. mansoni. We also report the immunologic and lung imaging findings from the studies reviewed. Methods: We carried out a comprehensive literature search in Embase and MEDLINE from the inception of the databases to 13th March 2023. Results: A total of 2243 patients with S. mansoni were reported from 24 case reports, 11 cross-sectional studies, 7 case series, 2 cohort studies and 2 randomized controlled trials. The prevalence of any respiratory symptom was 13.3–63.3% (total number of patients studied, n = 149). The prevalence of the individual symptoms among patients with S. mansoni in whom respiratory symptoms were sought for was as follows: cough (8.3–80.6%, n = 338), dyspnea (1.7–100.0%, n = 200), chest pain (9.0–57.1%, n = 86), sputum production (20.0–23.3%, n = 30) and wheezing (0.0 – 20.0%, n = 1396). The frequency of the symptoms tended to be higher in acute schistosomiasis. Restrictive lung disease was prevalent in 29.0% (9/31). The commonest chest imaging findings reported were nodules (20–90%, n = 103) and interstitial infiltrates (12.5–23.0%, n = 89). Peripheral blood eosinophilia was prevalent in 72.0–100.0% of patients ( n = 130) with acute schistosomiasis and correlated with symptoms and imaging abnormalities. Three case reports in chronic S. mansoni reported elevated C-reactive protein, leucocyte, neutrophil and absolute eosinophil counts, eosinophil percentage, IgE and IgG4. Conclusion: There is a high prevalence of respiratory morbidity among patients with S. mansoni, particularly in the acute stage of the infection, although the studies are relatively small. Larger studies are needed to characterize respiratory morbidity in chronic schistosomiasis and determine the underlying clinical and immunological mechanisms.

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Section: Resultsmentioning

confidence: 99%

Section: Study Selectionmentioning

confidence: 99%

Respiratory morbidity in Schistosoma mansoni infection: a rapid review of literature

Baluku,

Olum,

Sanya

et al. 2023

Therapeutic Advances in Infection

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“…While some eggs break loose into the intestinal or bladder lumina and are excreted in the feces or urine, others remain trapped within the intestinal or bladder walls, triggering host infl ammatory and immunological responses, leading to granuloma formation during the active phase of infection, which eventually involutes to leave degenerate, calcifi ed ova. While most granulomas resolve with little or no permanent fi brosis or clinical sequelae, infl ammatory pseudopolyps, 5 mucosal erosions, and ulcerations, 6,7 and peritoneal "bilharziomas" (fi brotic egg masses) 8 have been reported with chronic S. mansoni and S. japonicum infections. Other chronic manifestations and complications of intestinal schistosomiasis include gastrointestinal hemorrhage from severe ulcerations, 9 diarrhea (with or without hemtochezia), intestinal obstruction from strictures, 10,11 ischemic colitis, 12 appendicitis, and peritonitis from colonic perforation.…”

Section: Discussionmentioning

confidence: 99%

Intestinal schistosomiasis manifesting as colonic intussusception arising from a mucocele of the appendix: Report of a case

2008

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We report a case of intestinal schistosomiasis manifesting as colonic intussusception resulting from a mucocele of the appendix, caused by the obstruction of appendiceal outflow by schistosome egg-induced fibrosis. An 81-year-old woman from China presented with a tender right iliac fossa mass and computed tomography (CT) showed intussusception in the ascending colon. Exploratory laparotomy confirmed an appendiceal mass causing intussusception of the cecum into the ascending colon, with the appendix as the lead point, and lymphnode enlargement. We performed a right hemicolectomy for the appendiceal tumor. However, histologic examination revealed schistosoma eggs within the mucosa, submucosa, muscularis propria, and subserosal fat of the appendix, cecum, and ascending colon, and lymph nodes. The absence of dysplasia in the appendiceal mucosa indicated that the mucocele had developed from fibrosis induced by schistosome eggs obstructing the luminal outflow of mucin. Postoperatively, the patient was given praziquantel and recovered well.

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“…Large, mass-like lesions called bilharziomas can cause intestinal obstruction [50] or be confused with malignancy [51,52]. Histopathologic examination reveals the characteristic schistosome eggs within the inflammatory mass.…”

Section: Intestinal Schistosomiasismentioning

confidence: 99%

Gastrointestinal complications of schistosomiasis

Schafer

Hale²

2001

Curr Gastroenterol Rep

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Schistosomiasis is an important disease in many parts of the world and has affected the course of human history many times over. The parasitic infection is acquired during contact with infected water. A chronic inflammatory response to schistosome eggs, mediated by both cellular and humoral mechanisms, is the root of the pathology seen in schistosomiasis. Hepatosplenic disease results in intrahepatic presinusoidal portal hypertension. The resultant esophageal and gastric varices are an important cause of morbidity and mortality. Standard treatment guidelines for managing varices can be applied to patients with schistosomiasis. Coinfection with viral hepatitis results in liver disease that progresses more rapidly and is more difficult to treat. Intestinal schistosomiasis may be confused with other disease states and can be an important cause of morbidity, especially in heavily infected patients. Diagnosis relies on demonstration of schistosome eggs in feces or tissue. Praziquantel is the treatment of choice. The development of a vaccine for schistosomiasis is an important goal in the attempt to control this disease.

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Bilharzial pseudotumors—Dramatic manifestation of schistosomiasis: Report of a case

Cited by 7 publications

References 7 publications

Respiratory morbidity in Schistosoma mansoni infection: a rapid review of literature

Respiratory morbidity in Schistosoma mansoni infection: a rapid review of literature

Intestinal schistosomiasis manifesting as colonic intussusception arising from a mucocele of the appendix: Report of a case

Gastrointestinal complications of schistosomiasis

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