Biliary Complications after Orthotopic Liver Transplantation

Buck, David G.; Zajko, Albert B.

doi:10.1053/j.tvir.2008.05.006

Cited by 28 publications

(18 citation statements)

References 46 publications

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“…Of all liver transplantation, a mortality rate of 8%–15% is associated with biliary complications12. Biliary complications may be attributed to a variety of factors which includes hepatic artery thrombosis3, prolonged cold injury time456, warm ischemia- reperfusion injury467, and immunological rejection89 and have been variously associated with structural changes and functional lesions of the biliary tract following grafting.…”

mentioning

confidence: 99%

Impact of Recombinant Globular Adiponectin on Early Warm Ischemia-Reperfusion Injury in Rat Bile Duct after Liver Transplantation

Yang

Gong

2014

Sci Rep

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Adiponectin (APN) is an adipocyte protein with anti-diabetic properties, which has been recently revealed to have anti-inflammatory activity in organ ischemia- reperfusion injury (IRI). However, little is known about its function in bile duct IRI after liver transplantation. Therefore, we investigated whether APN affects early warm IRI in rat bile duct using a liver autologous transplantation model. In our study, rats were randomly divided into three experimental groups: a sham group, a IRI group, and a APN group. The serum enzyme levels and BDISS scores of bile duct histology associated with bile duct injury, decreased after administration of APN. Subsequently, the expression of proinflammatory cytokines, such as tumor necrosis factor(TNF-α),.interleukin-6(IL-6) and myeloperoxidase (MPO) decreased. Furthermore, pretreatment with APN suppressed the activation of nuclear factor-kappa B (NF-κB) (p65), a transcription factor involved in inflammatory reactions, compared to other two groups. Administration of APN also downregulated the expression of Fas protein and attenuated caspase-3 activity to decrease bile duct apoptosis. Our results illustrate that APN protects the rat bile duct against early warm IRI by suppressing the inflammatory response and hepatocyte apoptosis, and NF-κB (p65) plays an important role in this process.

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mentioning

confidence: 99%

Impact of Recombinant Globular Adiponectin on Early Warm Ischemia-Reperfusion Injury in Rat Bile Duct after Liver Transplantation

Yang

Gong

2014

Sci Rep

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“…The preferred technique at that time was to push the stents into the bowel by means of an angioplasty balloon catheter (A. Zajko, personal communication). More recently, Buck et al [3] described removing these stents with a snare, as was done in the three cases presented here, either by removing them via the percutaneous tract or advancing them into the adjacent bowel. To our knowledge, this is a unique publication devoted to this subject.…”

Section: Discussionmentioning

confidence: 89%

“…At our institution, these stents are small-caliber plastic feeding tubes designed to pass into the small bowel once the biliary sutures dissolve [2,3]. Nearly all transplants at this instit u t i o n a r e e i t h e r a h e p a t i c o j e j u n o s t o m y o r choledochojejunostomy, and in all these cases stents are placed.…”

Section: Discussionmentioning

confidence: 99%

Retained surgical stents as a cause of biliary obstruction in pediatric liver transplants

et al. 2014

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“…Biliary complications following liver transplantation can potentially result in significant morbidity . This is more relevant in the context of not only living donor LT but also with split and technical‐variant grafts .…”

Section: Discussionmentioning

confidence: 99%

“…This is more relevant in the context of not only living donor LT but also with split and technical‐variant grafts . ERCP has been shown to be a safe and effective intervention tool for both diagnosis as well as simultaneous therapeutic management of biliary complications post‐LT . Experience in children post‐LT, although described earlier, is limited and mainly from the West .…”

Section: Discussionmentioning

confidence: 99%

Endoscopic retrograde cholangio-pancreatography in the management of biliary complications after paediatric liver transplantation - a retrospective study

Karthik

Quak

2017

Transpl Int

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The published paediatric experience with endoscopic retrograde cholangio-pancreatography (ERCP) in the diagnosis and management of biliary complications following liver transplantation (LT) is limited. We describe our experience with ERCP in the management of children following LT who presented with biliary complications, over a 20-year period (1995-2014). The retrospectively reviewed data are summarized descriptively. Of 94 children (47 boys) who received 102 liver transplants at our centre, seven children (five boys, two girls) underwent ERCP after liver transplantation. In total, 25 ERCP procedures were carried out in these patients. The median age at liver transplantation was 10.7 (3.9-16.2) years. The median interval between LT and the first ERCP was 28 days (12 days-6.8 years). All patients were on standard calcineurin-inhibitor-based immunosuppression regimens. Six of the seven patients underwent ERCP on more than one occasion [median number of ERCP sessions per patient- 4, (1-6)]. Seventeen procedures were carried out under conscious sedation, remaining eight under general anaesthesia. Sedation was achieved employing a standard regimen (Midazolam 5 mg with Pethidine 50 mg) and occasionally Fentanyl. ERCP is an effective and safe intervention from both diagnostic and therapeutic point of view, in the management of post-LT biliary complications in children.

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Biliary Complications after Orthotopic Liver Transplantation

Cited by 28 publications

References 46 publications

Impact of Recombinant Globular Adiponectin on Early Warm Ischemia-Reperfusion Injury in Rat Bile Duct after Liver Transplantation

Impact of Recombinant Globular Adiponectin on Early Warm Ischemia-Reperfusion Injury in Rat Bile Duct after Liver Transplantation

Retained surgical stents as a cause of biliary obstruction in pediatric liver transplants

Endoscopic retrograde cholangio-pancreatography in the management of biliary complications after paediatric liver transplantation - a retrospective study

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