Biliary Drainage Reduces Intestinal Barrier Damage in Obstructive Jaundice by Regulating Autophagy

Zhang, Xianfeng; Peng, Bojian; Zhang, Yuan; Zhang, Yongjun; Lu, Xiushan; Cao, Yanwen

doi:10.1155/2022/3301330

Cited by 4 publications

(2 citation statements)

References 30 publications

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“…The intestinal mucosal barrier has selective permeability. When the intestinal mucosal barrier is destroyed, mucosal inflammation can cause necrosis and shedding of epithelial cells, which increases intestinal mucosal permeability[ 85 ]. Structural damage to epithelial cells leads to changes in the tight connective structure and loss of protective effects so that various pathogenic substances in the intestinal cavity are absorbed into the body[ 86 ].…”

Section: Uc Intestinal Inflammatory Response Processmentioning

confidence: 99%

Molecular regulation mechanism of intestinal stem cells in mucosal injury and repair in ulcerative colitis

Zheng¹,

Duan²

2023

World J Gastroenterol

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Ulcerative colitis (UC) is a chronic nonspecific inflammatory disease with complex causes. The main pathological changes were intestinal mucosal injury. Leucine-rich repeat-containing G protein coupled receptor 5 (LGR5)-labeled small intestine stem cells (ISCs) were located at the bottom of the small intestine recess and inlaid among Paneth cells. LGR5+ small ISCs are active proliferative adult stem cells, and their self-renewal, proliferation and differentiation disorders are closely related to the occurrence of intestinal inflammatory diseases. The Notch signaling pathway and Wnt/β-catenin signaling pathway are important regulators of LGR5-positive ISCs and together maintain the function of LGR5-positive ISCs. More importantly, the surviving stem cells after intestinal mucosal injury accelerate division, restore the number of stem cells, multiply and differentiate into mature intestinal epithelial cells, and repair the damaged intestinal mucosa. Therefore, in-depth study of multiple pathways and transplantation of LGR5-positive ISCs may become a new target for the treatment of UC.

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Section: Uc Intestinal Inflammatory Response Processmentioning

confidence: 99%

Molecular regulation mechanism of intestinal stem cells in mucosal injury and repair in ulcerative colitis

Zheng¹,

Duan²

2023

World J Gastroenterol

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“…Understanding the pathophysiological changes in obstructive jaundice remains a challenge for planning current and future treatment [9,10].…”

Section: Introductionmentioning

confidence: 99%

Comparative study of the treatment of mechanical jaundice in men and women: a cross-sectional study

Marzoog

Vladimirovich

2022

Preprint

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Background: Cholithiasis remains the leading cause of obstructive jaundice. A tendency to cholithiasis is suggested in women. However, the underlying risk factors and statistical conformation are lacking. Aims: Retrospectively describe and assess the causes of obstructive jaundice, as well as demonstrate the changes in laboratory parameters in response to treatment. Objectives: The study describes a sample of patients with obstructive jaundice due to various causes. Material and methods: A retrospective cohort study involved 101 patients with cholithiasis for the period 14.01.2016-13.04.2018 treated surgically and or conservatively. The study involved 60 (59.40594 %) men and 41 (40.59406 %) females aged 16 to 100 years (mean; 64.9901, Std Err: 1.53787). Of 101, 54 (53.46535 %) patients live in the city and 47 (46.53465 %) live in the village. The patients passed a full blood count and biochemical analysis for at least two times. Data were collected from the Mordovian Republic Hospital and retrospectively analyzed. The consent of the patients has been taken for scientific purposes to analyze and publish the results of the study. For statistical analysis, used T test, one way ANOVA test, and Spearman correlation test by using Statistica program. Results: By the etiology of obstructive symptoms, the frequency of gallstones is reported in 37 (36.63366%) patients, acute pancreatitis in 23 (22.77228%) patients, post-cholecystectomy syndrome (PCS) in 8 (7.92079 %) patients, Hilar cholangiocarcinoma (HC, Klatskin tumor) in 1 (0.99010 %) patient, pancreatic cancer in 12 (11.88119 %) patients, acute biliary pancreatitis in 8 (7.92079 %) patients, pancreatic pseudotumor in 4 (3.96040%) patients, acute cholecystitis in 3 (2.97030 %) patients, papillary tumor in 2 (1.98020 %) patients, and pancreatic cyst in 3 (2.97030%) patients. In male group, the mean age is 62.7805 years (min; max, 16.00000; 86.000) years, (median; Std Err, 66.0000; 2.40541). In the female group, the mean age is 66.5000 years (min; max, 24.00000; 100.000) years, (median; Std Err, 65.5000; 1.99300). Of 101 patients, 20 (19.80%) patients underwent surgical treatment and 81 (80.20%) patients did not require surgery. The mean total hospitalization days for patients who passed EPST surgery is 16.20000 days (Std Err 1.008850), CBD 21.50000 days (Std Err 1.565248), CDBD 25.00000 days, cholecystostomy 14.00000 days and hepaticocholecystoenterostomy 16.00000 days (Std Err 2.000000). In male group, the mean total hospitalization days 15.8537 (min; max, 5.00000; 30.000) days, (median; Std Err, 15.0000; 0.89071). In the female group, the mean total hospitalization days 14.0833 (min; max, 6.00000; 29.000) days, (median; Std Err, 13.5000; 0.68901). A direct association between the glucose value and the age, the correlation coefficient value -0.961980. Conclusions: Tendency to the early occurrence of obstructive jaundice symptoms in men compared to women. In treatment plans, men and females required the same total hospitalization days. The incidence rate of cholithiasis in females is higher than in males. Other findings: A straight association between age and the etiology of obstructive jaundice symptoms as well as a straight association between total hospitalization days and the type of surgery.

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Omega-3 Polyunsaturated Fatty Acids Alleviate Intestinal Barrier Dysfunction in Obstructive Jaundice Rats

Zhang

Yin

et al. 2023

Mol Biotechnol

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Biliary Drainage Reduces Intestinal Barrier Damage in Obstructive Jaundice by Regulating Autophagy

Cited by 4 publications

References 30 publications

Molecular regulation mechanism of intestinal stem cells in mucosal injury and repair in ulcerative colitis

Molecular regulation mechanism of intestinal stem cells in mucosal injury and repair in ulcerative colitis

Comparative study of the treatment of mechanical jaundice in men and women: a cross-sectional study

Omega-3 Polyunsaturated Fatty Acids Alleviate Intestinal Barrier Dysfunction in Obstructive Jaundice Rats

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