Biliary dysfunction (according to recommendations of Rome IV): diagnosis, treatment

Минушкин, О. Н.; Maslovsky, L. V.; Lvova, N V; Legkova, K. S.; Gordienko, E. S.; Protsenko, O. A.; Magomedrasulova, A. V.; Шапошникова, О. Ф.

doi:10.33667/2078-5631-2020-10-5-10

Medicinskij alfavit

2020

DOI: 10.33667/2078-5631-2020-10-5-10

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Biliary dysfunction (according to recommendations of Rome IV): diagnosis, treatment

О. Н. Минушкин

L. V. Maslovsky

N V Lvova³

et al.

Abstract: The paper presents information on modern functional disorders of the gastrointestinal tract and biliary system, based on the recommendations of the Rome IV. Own studies on the effectiveness of treatment of biliary functional disorders with Niaspam (mebeverine hydrochloride) are presented. We studied 30 patients with biliary pain and functional disorders of the gallbladder. As a result of studies, it was found that the symptoms of biliary dysfunction stop in 83.3 % of patients, the contractility of the gallblad… Show more

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2024

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“…Увеличение распространенности ЖКБ при НАЖБП связано с ростом среди населения общих факторов риска -абдоминальное ожирение, признаки инсулинорезистентности или сахарный диабет 2-го типа [4][5][6][7][8].…”

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Biochemical and structural changes in bile in non-alcoholic fatty liver disease

Vakhrushev,

Kosareva,

Suchkova

et al. 2024

ECG

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The purpose of the work is to diagnose the early stage of cholelithiasis through a comprehensive study of bile in patients with NAFLD. Materials and methods. We examined 210 patients with NAFLD at the steatosis stage. The diagnosis was confirmed based on general clinical indicators, ultrasound and liver elastography data, and assessment of blood enzyme levels. All patients underwent ultrasound examination of the gallbladder, study of the microscopic and physicochemical properties of bile (specific gravity, acidity, surface tension, viscosity, lithogenicity indices, cholesterol content, bile acids, phospholipids) obtained as a result of multifractional duodenal intubation, and crystallography. Results: Ultrasound examination revealed biliary sludge in 72% of patients. Microscopic examination of bile revealed crystals of cholesterol and calcium bilirubinate in 75.4% of patients. Biochemical analysis of bile revealed significant changes, expressed in increased cholesterol, decreased bile acids, phospholipids, cholate-cholesterol and phospholipid-cholesterol ratios. A study of the physical properties revealed thickening of bile and an increase in its viscosity. Crystallography revealed elements with high optical activity, which became the basis for the formation of gallstones. Conclusions: In patients in the steatosis stage of NAFLD, a decrease in lithogenicity indices, an increase in acidity and thickening of bile are determined, indicating the tendency of bile to stone formation. Signs of biliary sludge (putty-like bile, microlithiasis), characteristic of stage I cholelithiasis, are detected by ultrasound of the gallbladder in 72% of patients in the steatosis stage of NAFLD. Bile crystallography made it possible to identify crystal optical markers indicating changes in the microstructure of gallbladder bile in patients in the steatosis stage of NAFLD. When conducting an examination of patients with NAFLD in the steatosis stage, to diagnose the early stage of cholelithiasis, it is recommended to conduct multifractional duodenal intubation with subsequent study of the physicochemical properties and structural changes of bile.

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Biochemical and structural changes in bile in non-alcoholic fatty liver disease

Vakhrushev,

Kosareva,

Suchkova

et al. 2024

ECG

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show abstract

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Biliary dysfunction (according to recommendations of Rome IV): diagnosis, treatment

Cited by 1 publication

References 2 publications

Biochemical and structural changes in bile in non-alcoholic fatty liver disease

Biochemical and structural changes in bile in non-alcoholic fatty liver disease

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