1971
DOI: 10.4269/ajtmh.1971.20.667
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Biliary Tract Changes in Opisthorchiasis

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Cited by 20 publications
(6 citation statements)
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“…For opistriorchiasis, previous autopsy studies in man are either descriptive (Sonakul et al 1978), nonquantitative in nature (Evans et al 1971;Koompirochana et al 1978), or of limited sample size (Viranuvatti & Mettiyawongse, 1953). Our study has obtained evidence for the existence of a relationship between epg and fluke burden in man based on a large sample size.…”
Section: Discussionmentioning
confidence: 99%
“…For opistriorchiasis, previous autopsy studies in man are either descriptive (Sonakul et al 1978), nonquantitative in nature (Evans et al 1971;Koompirochana et al 1978), or of limited sample size (Viranuvatti & Mettiyawongse, 1953). Our study has obtained evidence for the existence of a relationship between epg and fluke burden in man based on a large sample size.…”
Section: Discussionmentioning
confidence: 99%
“…This observation presents three likely possibilities; firstly, biliary obstruction due to the parasites may prevent the entry of ova into the gut, secondly, it is possible that the worms may have been damaged by resulting immunological precesses following adoptive transfer of cells and/or serum and, thirdly, the ova themselves may have been damaged or eliminated in the gut by immonological processes. With respect to the last possibility, it has been shown that the ova of C. sinensis are nonantigenic in the host (Sun, 1969b;Sun and Gibson, 1969), and, whilst this has not been investigated for O. viverrini, the close parallel in the pathological response of the host seen for both these parasites (Hou, 1955;Evans et al, 1971) suggests that in all probability O. viverrini ova are also likely to be non-antigenic. However, this point requires further investigation.…”
Section: Tablementioning
confidence: 99%
“…The extensive use of a fish sauce containing nitrites and other potential carcinogen precursors further suggests that significant exposure to chemical carcinogens may occur via endogenous formation in the gut. 7) In the Syrian hamster, infection with liver flukes causes proliferative and inflammatory changes analogous to those observed in man 8,9) and results in liver tumors when associated with nitrosamine exposure. 10,11) One approach to elimination of this problem has been removal of the parasite stimulus by a combination of education and chemotherapy, principally involving use of the antihelminthic drug, praziquantel (2-cyclohexylcarbonyl-1,2,3,6,7,11b-hexahydro-4H-pyrazino [2,1-a]isoquinolin-4one EMBAY 8440, Biltricide@).…”
mentioning
confidence: 97%