Biliary Tract Malignancies Related to Gallbladder Polyps, Primary Sclerosing Cholangitis, and Choledochal Cysts

Zia, Hassaan; Siddiqui, Uzma D.

doi:10.1002/cld.1101

Clinical Liver Disease

2021

DOI: 10.1002/cld.1101

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Biliary Tract Malignancies Related to Gallbladder Polyps, Primary Sclerosing Cholangitis, and Choledochal Cysts

Hassaan Zia

Uzma D. Siddiqui

Abstract: Biliary tract neoplasia may be entirely asymptomatic or associated with symptoms and signs such as abdominal pain, jaundice, recurrent cholangitis, or pruritus. We aim to discuss key clinical and imaging features with evidencebased management principles for benign and malignant biliary neoplastic lesions.

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2024

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Cited by 1 publication

References 22 publications

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Establishing a Preoperative Predictive Model for Gallbladder Adenoma and Cholesterol Polyps Based on Machine Learning: A Multicentre Retrospective Study

Wang,

Qu,

Zeng

et al. 2024

Preprint

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Background With the rising diagnostic rate of gallbladder polypoid lesions (GPLs), differentiating benign cholesterol polyps from gallbladder adenomas with a higher preoperative malignancy risk is crucial. This study aimed to establish a preoperative prediction model capable of accurately distinguishing between gallbladder adenomas and cholesterol polyps using machine learning algorithms. Materials and Methods We retrospectively analysed the patients' clinical baseline data, serological indicators, and ultrasound imaging data. Using 12 machine learning algorithms, 110 combination predictive models were constructed. The models were evaluated using internal and external cohort validation, receiver operating characteristic curves, area under the curve (AUC) values, calibration curves, and clinical decision curves to determine the best predictive model. Results Among the 110 combination predictive models, the Support Vector Machine + Random Forest (SVM + RF) model demonstrated the highest AUC values of 0.972 and 0.922 in the training and internal validation sets, respectively, indicating an optimal predictive performance. The model-selected features included gallbladder wall thickness, polyp size, polyp echo, and pedicle. Evaluation through external cohort validation, calibration curves, and clinical decision curves further confirmed its excellent predictive ability for distinguishing gallbladder adenomas from cholesterol polyps. Additionally, this study identified age, adenosine deaminase level, and metabolic syndrome as potential predictive factors for gallbladder adenomas. Conclusion This study employed the latest machine learning combination algorithms and preoperative ultrasound imaging data to construct an SVM + RF predictive model, enabling effective preoperative differentiation of gallbladder adenomas and cholesterol polyps. These findings will assist clinicians in accurately assessing the risk of GPLs and providing personalised treatment strategies.

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Establishing a Preoperative Predictive Model for Gallbladder Adenoma and Cholesterol Polyps Based on Machine Learning: A Multicentre Retrospective Study

Wang,

Qu,

Zeng

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

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Biliary Tract Malignancies Related to Gallbladder Polyps, Primary Sclerosing Cholangitis, and Choledochal Cysts

Cited by 1 publication

References 22 publications

Establishing a Preoperative Predictive Model for Gallbladder Adenoma and Cholesterol Polyps Based on Machine Learning: A Multicentre Retrospective Study

Establishing a Preoperative Predictive Model for Gallbladder Adenoma and Cholesterol Polyps Based on Machine Learning: A Multicentre Retrospective Study

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