BiliScreen

Mariakakis, Alex; Banks, Megan A.; Phillipi, Lauren; Lei, Yu; Taylor, James A.; Patel, Shwetak

doi:10.1145/3090085

Cited by 35 publications

(17 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One smartphone-based technique has used the scleral color to identify jaundiced adult patients with pancreatic cancer [8]. After considering 105 color features with different color spaces, color channels, pixel selection methods and RGB ratios, the study found that the ratio of green to blue channels in the RGB color space is one color metric that best correlates with the data.…”

Section: Discussionmentioning

confidence: 99%

Jaundice Eye Color Index (JECI): quantifying the yellowness of the sclera in jaundiced neonates with digital photography

Leung

Outlaw

MacDonald

et al. 2019

Biomed. Opt. Express

View full text Add to dashboard Cite

The sclera is arguably a better site than the skin to measure jaundice–especially in dark-skinned patients–since it is free of skin pigment (melanin), a major confounding factor. This work aims to show how the yellowness of the sclera can be quantified by digital photography in color spaces including the native RGB and CIE XYZ. We also introduce a new color metric we call “Jaundice Eye Color Index” (JECI) which allows the yellowness of jaundiced sclerae to be predicted for a specific total serum bilirubin level in the neonatal population.

show abstract

Section: Discussionmentioning

confidence: 99%

Jaundice Eye Color Index (JECI): quantifying the yellowness of the sclera in jaundiced neonates with digital photography

Leung

Outlaw

MacDonald

et al. 2019

Biomed. Opt. Express

View full text Add to dashboard Cite

show abstract

“…Research interest in smartphone-based jaundice screening is growing, and recent work is promising [15][16][17][18][19][20][21][22]. The most extensively validated system is the BiliCam app that estimates total serum bilirubin (TSB) based on the skin colour of the sternum [15].…”

Section: Plos Onementioning

confidence: 99%

“…The sclera accumulates bilirubin while lacking the melanin and haemoglobin chromophores found in skin. It has been suggested that this permits a more sensitive measure of jaundice [17,23]. Secondly, we introduce a novel ambient subtraction method using the screen of the phone to illuminate the subject.…”

Section: Plos Onementioning

confidence: 99%

See 1 more Smart Citation

Smartphone screening for neonatal jaundice via ambient-subtracted sclera chromaticity

et al. 2020

View full text Add to dashboard Cite

Jaundice is a major cause of mortality and morbidity in the newborn. Globally, early identification and home monitoring are significant challenges in reducing the incidence of jaundicerelated neurological damage. Smartphone cameras are promising as colour-based screening tools as they are low-cost, objective and ubiquitous. We propose a novel smartphone method to screen for neonatal jaundice by imaging the sclera. It does not rely on colour calibration cards or accessories, which may facilitate its adoption at scale and in less economically developed regions. Our approach is to explicitly address three confounding factors in relating colour to jaundice: (1) skin pigmentation, (2) ambient light, and (3) camera spectral response. (1) The variation in skin pigmentation is avoided by imaging the sclera. (2) With the smartphone screen acting as an illuminating flash, a flash/ no-flash image pair is captured using the front-facing camera. The contribution of ambient light is subtracted. (3) In principle, this permits a device-and ambient-independent measure of sclera chromaticity following a one-time calibration. We introduce the concept of Scleral-Conjunctival Bilirubin (SCB), in analogy with Transcutaneous Bilirubin (TcB). The scleral chromaticity is mapped to an SCB value. A pilot study was conducted in the UCL Hospital Neonatal Care Unit (n = 37). Neonates were imaged using a specially developed app concurrently with having a blood test for total serum bilirubin (TSB). The better of two models for SCB based on ambient-subtracted sclera chromaticity achieved r = 0.75 (p<0.01) correlation with TSB. Ambient subtraction improved chromaticity estimates in proof-of-principle laboratory tests and screening performance within our study sample. Using an SCB decision threshold of 190μmol/L, the sensitivity was 100% (specificity 61%) in identifying newborns with TSB>250μmol/L (area under receiver operating characteristic curve, AUROC, 0.86), and 92% (specificity 67%) in identifying newborns with TSB>205μmol/L (AUROC 0.85). These results are comparable to modern transcutaneous bilirubinometers.

show abstract

“…Sclera segmentation algorithms have been developed by researchers interested in biometric identification using sclera vasculature [42,43]. Mariakakis et al developed their own segmentation using accessories as fiducials [17].…”

Section: Limitations and Future Workmentioning

confidence: 99%

Smartphone screening for neonatal jaundice via ambient-subtracted sclera chromaticity:neoSCBapp pilot study

Outlaw

Nixon

Odeyemi

et al. 2019

Preprint

View full text Add to dashboard Cite

Jaundice is a major cause of mortality and morbidity in the newborn. Globally, early identification and home monitoring are significant challenges in reducing the incidence of jaundice-related neurological damage. Smartphone cameras are promising as colour-based screening tools as they are low-cost, objective and ubiquitous. We propose a novel smartphone method and app called neoSCB to screen for neonatal jaundice by imaging the sclera. It does not rely on colour calibration cards or accessories, which may facilitate its adoption at scale and in less economically developed regions. Our approach is to explicitly address three confounding factors in relating colour to jaundice: (1) skin pigmentation, (2) ambient light, and (3) camera spectral response. (1) The variation in skin pigmentation is avoided by imaging the sclera. (2) With the smartphone screen acting as an illuminating flash, a flash/ no-flash image pair is captured using the front-facing camera. The contribution of ambient light is subtracted. (3) This permits a device-and ambient-independent measure of sclera chromaticity following a one-time calibration. We introduce the concept of Scleral-Conjunctival Bilirubin (SCB), in analogy with Transcutaneous Bilirubin (TcB). The scleral chromaticity is mapped to an SCB value. A pilot study was conducted in the UCL Hospital Neonatal Care Unit. 51 neonates were imaged using the neoSCB app and had a blood test for total serum bilirubin (TSB). The better of two models for SCB based on ambient-subtracted sclera chromaticity achieved r = 0.75 (p<0.01) correlation with TSB. Ambient subtraction improved chromaticity estimates in laboratory tests and screening performance within our study sample. Using an SCB decision threshold of 190μmol/L, the sensitivity was 100% (specificity 61%) in identifying newborns with TSB>250μmol/L (area under receiver operating characteristic curve, AUROC, 0.86), and 92% (specificity 67%) in identifying newborns with TSB>205μmol/L (AUROC 0.85). These results are comparable to modern transcutaneous bilirubinometers.

show abstract

BiliScreen

Cited by 35 publications

References 23 publications

Jaundice Eye Color Index (JECI): quantifying the yellowness of the sclera in jaundiced neonates with digital photography

Jaundice Eye Color Index (JECI): quantifying the yellowness of the sclera in jaundiced neonates with digital photography

Smartphone screening for neonatal jaundice via ambient-subtracted sclera chromaticity

Smartphone screening for neonatal jaundice via ambient-subtracted sclera chromaticity:neoSCBapp pilot study

Contact Info

Product

Resources

About