Bimetallic Cobalt Copper Organic Framework Integrating Multi-Wall Carbon Nanotubes and Gold Nanoparticles for Glucose Sensor

Abstract

Bimetallic metal-organic framework CuCo-BTC was synthesized via a facile hydrothermal method and then a CuCo-BTC coated Au/multi-wall carbon nanotubes (MWCNTs) electrode (CuCo-BTC/Au/MWCNTs/CF) was prepared on copper foam for glucose sensing. Due to the synergic catalytic effect of Cu and Co, excellent conductivity and large surface area of MWCNTs, and good catalytic property of gold, CuCo-BTC/Au/MWCNTs/CF can provide more effective active sites, so as to improve the charge transports and the electro-catalytic performance. As a result, under optimized conditions, the electrode exhibits a wide linear range of 0.01-5 mM, 5-9 mM, a sensitivity of 1.029 mA·mM-1·cm-2, and a detection limit of 3.4 μM (S/N =3) for glucose detection. Meanwhile, it also demonstrates satisfactory selectivity, reproducibility, and stability. Furthermore, the electrode was successfully applied for the detection of glucose in serum, this work validates the potential of the fabricated sensor for non-enzymatic blood glucose monitoring.